Cubs vs. Brewers Prediction, Odds & Best Bets: Who Takes Temporary NL Central Lead?

The Cubs and the Brewers meet tonight in Milwaukee with first place in the NL Central on the line.

Gabe Henderson

Last Updated: July 28, 2025 3:30 PM EDT • 4 minute read

Cubs vs. Brewers Prediction, Odds & Best Bets: Monday, July 28 — Pictured: Chicago Cubs pitcher Matthew Boyd (16) delivers as we make our Cubs vs. Brewers prediction. Photo by Matt Marton via Imagn Images.

First place in the NL Central is on the line in Milwaukee tonight with Chicago coming to town, and my Cubs vs. Brewers prediction breaks down the bout.

First pitch from American Family Field in Milwaukee is set for 7:40 p.m. ET (FDSN Wisconsin, MSN). The best sports betting sites list the visitors (-115) as slim betting favorites, with the hosts also trading at minus-money odds.

My Cubs vs. Brewers best bets rely on the red-hot Matthew Boyd, who takes the mound for Chicago tonight. Dustin Saracini is also banking on Boyd to succeed against the Brewers in his best NRFI bets today.

Cubs vs. Brewers prediction: Cubs to win (-115 via BetMGM) ⭐⭐⭐
Best Cubs vs. Brewers player props: Matthew Boyd Over 4.5 strikeouts (-135 via Caesars) ⭐⭐⭐⭐

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✅ Cubs vs. Brewers prediction: Cubs to win (-115 via BetMGM)

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We're over 105 games into the season, so success is no longer a fluke. There's no two ways about it, Chicago and Milwaukee are two of baseball's best teams. There's been nothing to separate the two teams (62-43) thus far, and with two of the league's best arms on the bump, my Cubs vs. Brewers prediction becomes even tougher.

I'm giving a slight lean to the visitors - as are our best sports betting apps - because of how dominant Boyd has been lately. In addition to winning his last five starts, he's not gotten a losing decision since June 4. Chicago has been in scorching form behind the southpaw, and I'm betting on that success to continue after taking three of five from Milwaukee earlier in the campaign.

Jacob Misiorowski has enjoyed a sensational start to his young career, including a gem against the Dodgers before the break. However, I have a hard time betting on a rookie with just six starts under his belt against baseball's best offense.

My Cubs vs. Brewers best bet sides with experience. Chicago has -115 moneyline odds at most of our best sportsbooks, with FanDuel (-116) being the lone exception. These odds imply a 53.49% probability that the Cubs become the first team in baseball to 30 road wins.

💰 Best Cubs vs. Brewers player props

✅ Best Cubs vs. Brewers player prop: Matthew Boyd Over 4.5 strikeouts (-135 via Caesars)

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My best Cubs vs. Brewers player prop tails Dustin Saracini's best strikeout props today. Like my colleague, I believe Boyd's line is way too low in this game, and it shows a bit too much respect to the Milwaukee lineup.

The Chicago lefty has gone deep into games this month, only being pulled before seven innings of work once in four starts. He's cleared this total in each of his last four outings, as well. The Brewers don't strike out often - just 7.99 times per game - but Boyd has cut down more disciplined teams (Kansas City, St. Louis) while clearing this total in two of his last three.

I'm playing this prop at four-star confidence with Caesars at -135 odds, which offers slightly more value than BetMGM and DraftKings (-140).

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Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.

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The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.