Cardinals vs. Dodgers Prediction, Odds & Best Bets: Bats Lift LA Back Into Win Column

Last Updated: August 5, 2025 4:56 PM EDT • 4 minute read X Social Google News Link

St. Louis shocked Los Angeles in the series opener behind a superb effort from Sonny Gray, but my Cardinals vs. Dodgers prediction expects the hosts to bounce back tonight with a better offensive showing.
The best sports betting sites concur, listing the Dodgers as -185 betting favorites with a total set at O/U 9.5. First pitch is scheduled for 10:10 p.m. ET (MLB Network) from Dodger Stadium in Los Angeles.
My Cardinals vs. Dodgers best bets back the hosts, who have traditionally fared well against St. Louis starter Miles Mikolas during his decade-long MLB career.
- Cardinals vs. Dodgers prediction: Dodgers to win (-185 via bet365) ⭐⭐⭐⭐
- Best Cardinals vs. Dodgers player props: Freddie Freeman Over 1.5 bases (+100 via DraftKings) ⭐⭐⭐⭐
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💰 Cardinals vs. Dodgers prediction & best bet
✅ Cardinals vs. Dodgers prediction: Dodgers to win (-185 via bet365)
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My Cardinals vs. Dodgers prediction for the series opener vastly underestimated the level at which St. Louis' ace was playing this season. Gray tossed a gem with eight strikeouts, and a solo home run was his only mistake across seven frames.
Unfortunately for the visitors, tonight's starter has struggled recently, surrendering three-plus earned runs at a 50% clip over his last 10 outings. Mikolas' career stats against Los Angeles aren't flattering, as he comes into tonight's contest with a 1-4 record and a 5.50 ERA in nine games versus the World Series odds favorites.
Dave Roberts' men have traditionally hit the veteran extremely well, as their matchup stats show:
- Mookie Betts: 4-for-10 (.400)
- Michael Conforto: 3-for-11 (.273)
- Freddie Freeman: 9-for-20 (.450)
- Shohei Ohtani: 4-for-8 (.500)
- Miguel Rojas: 4-for-11 (.364)
After managing just three hits in the series opener, my Cardinals vs. Dodgers best bet anticipates an offensive resurgence in Chavez Ravine tonight. Los Angeles is a -185 betting favorite at the best sports betting apps, implying a 64.91% chance that the hosts will return to their winning ways.
💰 Best Cardinals vs. Dodgers player props
✅ Best Cardinals vs. Dodgers player prop: Freddie Freeman Over 1.5 bases (+100 via DraftKings)
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My best Cardinals vs. Dodgers player prop looks to capitalize on Los Angeles' aforementioned success against Mikolas. I'm turning to Freeman as the most successful head-to-head hitter versus St. Louis' starter, given he's hitting .350 since returning from the All-Star break.
In addition to a .950 career slugging percentage against Mikolas, Freeman has cleared this total in each of his last six games. He's achieved this feat with five extra-base hits and four multi-hit games, solidifying his spot as one of baseball's most in-form hitters.
DraftKings is the only one of the best sportsbooks offering this play at even money. Freeman Over 1.5 total bases is trading at standard -110 odds or longer at BetMGM, bet365, and Caesars.
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❓MLB betting FAQs
How do betting odds work?
Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.
What is the run line in baseball?
The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.
What does moneyline mean in betting?
The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.
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