Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Sept. 11

A scorching Seattle team takes on a struggling starter tonight, which is why Julio Rodriguez is featured in my best home run predictions today.

Gabe Henderson

Last Updated: September 11, 2025 8:28 AM EDT • 3 minute read

Home Run Predictions Today: Best MLB Odds, Picks & Prop Bets for Sept. 11 — Pictured: Seattle Mariners outfielder Julio Rodriguez (44) celebrates after he hit a home run. Photo by Kim Klement Neitzel via Imagn Images.

Only 18 of the MLB's 30 teams are active on Thursday, but my best home run predictions today still find plenty of value.

My best home run bets today feature Julio Rodriguez, who gets a favorable pitching matchup as the Seattle Mariners look to stay hot tonight. I also include Jose Altuve, Juan Soto, and Fernando Tatis Jr. in my MLB picks.

If all four players hit dingers, a $10 parlay will pay out nearly $12,100 in profits!

💰 MLB best home run predictions & odds today: Sept. 11

Best home run predictions today based on the latest MLB odds.

Jose Altuve to hit a home run (+680 via FanDuel) ⭐⭐⭐
Juan Soto to hit a home run (+400 via FanDuel) ⭐⭐⭐
Fernando Tatis Jr. to hit a home run (+380 via DraftKings) ⭐⭐⭐⭐
Julio Rodriguez to hit a home run (+560 via FanDuel) ⭐⭐⭐⭐

💣 Best home run prediction today: MLB expert picks & prop bets

Here is my favorite MLB home run bet today and analysis of why it leads my MLB home run predictions.

⚾ Julio Rodriguez (Mariners) to hit a home run (+560) ⭐⭐⭐⭐

Seattle is in scorching form down the stretch, and it has its superstars - such as Rodriguez - to thank. The 24-year-old has tallied three multi-hit games in his last five outings to complement his four home runs over a 10-game stretch.

Rodriguez has excellent career numbers against Los Angeles starter Jose Soriano, slashing .500/.571/1.000. In total, the Mariners' outfielder has six hits in 12 at-bats against the righty, including two home runs. The Angels' arm gave up eight earned runs in his last outing against the A's, so I fear Seattle will shell him, and Rodriguez will likely contribute to that.

A $10 wager on Rodriguez to go yard returns $56 at FanDuel, with the odds implying a 15.15% chance he stuffs his stat sheet with No. 31 on the season.

📊 Angels vs. Mariners odds

🚀 Best home run parlay picks

Use our parlay calculator to get the best odds for any parlay.

Jose Altuve to hit a home run (+680 via FanDuel)
Juan Soto to hit a home run (+400 via FanDuel)
Fernando Tatis Jr. to hit a home run (+370 via FanDuel)
Julio Rodriguez to hit a home run (+560 via FanDuel)

Best parlay odds: +120878 via FanDuel ($10 to win $12,087.80)

💡 Expert MLB predictions today

❓ Best home run predictions FAQs

What are the best home run props for tonight?

Our best home run predictions today feature Jose Altuve, Julio Rodriguez, Juan Soto, and Fernando Tatis Jr.

What is a home run bet?

A home run bet is a wager on a hitter to hit a HR at any point during a game. Some sportsbooks allow you to bet on a hitter to not hit a home run, but the most common bet is on them to do so.

Can you parlay home run bets?

Yes, you can parlay home run bets. We've provided our best home run parlay today.

How do I place a home run bet?

To place a home run bet, simply go to your favorite sportsbook and go to the game featuring the player of your choice. Then click on batter props and you should see an option to bet a player to hit a home run.

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years bulding his college football and NFL experience. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.