Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Wednesday

My best home run predictions today feature prolific power hitters in Yordan Alvarez and Shohei Ohtani.

Gabe Henderson

Last Updated: September 10, 2025 2:22 PM EDT • 4 minute read

Home Run Predictions Today: Best MLB Odds, Picks & Prop Bets for Wednesday — Pictured: Houston Astros left fielder Yordan Alvarez (44) at bat. Photo by Jerome Miron via Imagn Images.

We look to stay in scorching form on the heels of a red-hot Dinger Tuesday, as my best home run predictions today turn to the familiar faces of some prolific power hitters.

Yordan Alvarez and Shohei Ohtani take center stage in my best home run bets today, as they seek to break out of relative slumps. Meanwhile, I look to some frequent fliers elsewhere tonight, with Kyle Schwarber and Daulton Varsho under the home run microscope.

If my four MLB picks cash, a $10 wager returns just over $1,400 in profit!

💰 MLB best home run predictions & odds today: Sept. 10

Best home run predictions today based on the latest MLB odds.

Kyle Schwarber to hit a home run (+350 via FanDuel) ⭐⭐⭐
Daulton Varsho to hit a home run (+285 via FanDuel) ⭐⭐⭐
Yordan Alvarez to hit a home run (+303 via DraftKings) ⭐⭐⭐⭐
Shohei Ohtani to hit a home run (+175 via DraftKings) ⭐⭐⭐⭐

💣 Best home run prediction today: MLB expert picks & prop bets

Here are my favorite MLB home run bets today and analysis of why they lead my MLB home run predictions.

⚾ Yordan Alvarez (Astros) to hit a home run (+175) ⭐⭐⭐⭐

Alvarez doesn't get hits off Jose Berrios very often, as evidenced by his .188 career batting average against the Blue Jays starter across 16 at-bats. But when he does, he hits the ball very far.

Houston is in desperate need of an offensive spark, and who better to provide that than the big man? Alvarez's two career home runs against Berrios rank tied for first among batters versus opposing starters in baseball today. He's hit twice as many home runs away from Daikin Park, as well, despite 23 fewer at-bats.

Today, the Yord is my shepherd. I'm riding with Alvarez to hit a third career four-bagger against Berrios in what Dustin Saracini expects to be a high-scoring affair, as outlined in his Astros vs. Blue Jays prediction.

📊 Astros vs. Blue Jays odds

⚾ Shohei Ohtani (Dodgers) to hit a home run (+175) ⭐⭐⭐⭐

Ohtani's home run-hitting pace has slowed down significantly in recent weeks, but he's still well on his way to tallying back-to-back seasons with 50-plus dingers. He's clubbed three round-trippers across his last 10 games, cashing this prop at a 20% clip. I expect him to go take one step closer tonight while getting a favorable pitching matchup.

Los Angeles' two-way superstar has faced Colorado southpaw Kyle Freeland eight times in his career. He's slashing .750/.750/1.625 in those at-bats while registering six hits, three of which went for extra bases. Ohtani has taken Freeland deep in 25% of his plate appearances against him, a worrying stat heading into Rockies vs. Dodgers for a starter who has surrendered 12 moon shots in his last 10 appearances.

If the 31-year-old hits No. 49 tonight, a $10 wager would return $17.50 on this bet, which carries an implied probability of 36.36%.

📊 Rockies vs. Dodgers odds

🚀 Best home run parlay picks

Use our parlay calculator to get the best odds for any parlay.

Kyle Schwarber to hit a home run (+350 via FanDuel)
Daulton Varsho to hit a home run (+285 via FanDuel)
Yordan Alvarez to hit a home run (+285 via FanDuel)
Shohei Ohtani to hit a home run (+164 via FanDuel)

Best parlay odds: +14014 via FanDuel ($10 to win $1,401.48)

💡 Expert MLB predictions today

❓ Best home run predictions FAQs

What are the best home run props for tonight?

Our best home run predictions today feature Yordan Alvarez, Shohei Ohtani, Kyle Schwarber, and Daulton Varsho.

What is a home run bet?

A home run bet is a wager on a hitter to hit a HR at any point during a game. Some sportsbooks allow you to bet on a hitter to not hit a home run, but the most common bet is on them to do so.

Can you parlay home run bets?

Yes, you can parlay home run bets. We've provided our best home run parlay today.

How do I place a home run bet?

To place a home run bet, simply go to your favorite sportsbook and go to the game featuring the player of your choice. Then click on batter props and you should see an option to bet a player to hit a home run.

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years bulding his college football and NFL experience. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.