Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Sept. 1

Our Mike Spector targets four stars to go deep today, including Willy Adames.

Mike Spector

Last Updated: September 1, 2025 8:39 AM EDT • 4 minute read

Home Run Predictions Today: Best MLB Odds, Picks & Prop Bets for Sept. 1 — Pictured: San Francisco Giants shortstop Willy Adames (2). Photo by Darren Yamashita via Imagn Images.

There are a ton of afternoon baseball games on this Labor Day Monday, which has me excited to cash some early best home run predictions today. My selections are centered around San Francisco Giants slugger Willy Adames, who has been on one of the hottest home run binges of any player in the league over the last two weeks.

My top home run bets today also back Vladimir Guerrero Jr., Jackson Chourio, and Cal Raleigh to hit home runs and round out our MLB picks.

If Guerrero, Chourio, Adames, and Raleigh all homer, my four-leg $10 parlay would net nearly $2700 in profits.

💰 MLB best home run predictions & odds today: Sept. 1

Best home run predictions today based on the latest MLB odds.

🧨 Vladimir Guerrero Jr. to hit a home run (+375 via bet365) ⭐⭐⭐
🧨 Jackson Chourio to hit a home run (+460 via FanDuel) ⭐⭐
🧨 Willy Adames to hit a home run (+300 via DraftKings) ⭐⭐⭐⭐
🧨 Cal Raleigh to hit a home run (+260 via DraftKings) ⭐⭐⭐

💣 Best home run prediction today: MLB expert picks & prop bets

Here is my favorite MLB home run bet today and analysis of why it leads my MLB home run predictions.

⚾ Willy Adames (Giants) to hit a home run ⭐⭐⭐⭐

Willy Adames has belted six home runs in the last 10 games, bringing his team-leading home run total to 25. Adames is looking to become the first Giants player to hit 30 home runs in a season since Barry Bonds in 2004.

Adames’ chances of hitting a home run are bolstered in the altitude of Coors Field, where he has hit nine home runs in 35 career games. He aims to tee off on Chase Dollander, who has allowed 10 home runs in 41 innings while pitching to a troubling 9.88 ERA at home.

Colorado has already set a franchise record for most home losses in a season (47), and I expect Adames to add to that misery.

Adames’ odds at the best MLB betting sites give him a 25% chance to homer. Bet this prop at DraftKings, which offers a more favorable price (+300) than the +270 at the market’s low end.

A $10 bet would net $30 in profit.

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📊 Giants vs. Rockies odds

🚀 Best home run parlay picks

Use our parlay calculator to get the best odds for any parlay.

💣 Vladimir Guerrero Jr. to hit a home run (+265 via FanDuel)
💣 Jackson Chourio to hit a home run (+460 via FanDuel)
💣 Willy Adames to hit a home run (+300 via FanDuel)
💣 Cal Raleigh to hit a home run (+230 via FanDuel)

Best parlay odds: +26880 via FanDuel ($10 to win $2688.08)

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💡 Expert MLB predictions today

MLB home run predictions today
Mets vs. Tigers
Braves vs. Cubs
Phillies vs. Brewers

❓ Best home run predictions FAQs

What are the best home run props for tonight?

My best home run predictions today feature Vladimir Guerrero Jr., Jackson Chourio, Willy Adames, and Cal Raleigh.

What is a home run bet?

A home run bet is a wager on a hitter to hit a HR at any point during a game. Some sportsbooks allow you to bet on a hitter to not hit a home run, but the most common bet is on them to do so.

Can you parlay home run bets?

Yes, you can parlay home run bets. We've provided our best home run parlay today.

How do I place a home run bet?

To place a home run bet, simply go to your favorite sportsbook and go to the game featuring the player of your choice. Then click on batter props and you should see an option to bet a player to hit a home run.

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike leans on his NFL experience and always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”