Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for June 1

We're backing Francisco Lindor, Isaac Paredes, Elly De La Cruz, and Vladimir Guerrero Jr. to go deep today.

Mike Spector

Last updated: June 1, 2025 4:28 PM EDT • 2 min read

Home Run Predictions Today: Best MLB Odds, Picks & Prop Bets for June 1 — Pictured: Cincinnati Reds designated hitter Elly De La Cruz (44) singles against the Kansas City Royals. Photo by Denny Medley / Imagn Images.

With two of MLB’s biggest stars featured in our Ohtani vs. Judge player props, we have centered our best home run predictions today around four other sluggers worth backing today to go deep.

If our four batters all go yard to cash our four-leg home run parlay, we are walking out with a profit of nearly $6,000 on our MLB picks.

💰 MLB best home run predictions & odds today: June 1

Here are my best MLB home run predictions and odds today with my pick confidence based on a 1-to-5-star scale. You can also check out our MLB player prop odds tool for the latest MLB odds at the best legal sportsbooks in your region.

🧨 Francisco Lindor to hit a home run (+340 via FanDuel) ⭐⭐
🧨 Isaac Paredes to hit a home run (+475 via bet365) ⭐⭐
🧨 Elly De La Cruz to hit a home run (+575 via bet365) ⭐⭐⭐
🧨 Vladimir Guerrero Jr. to hit a home run (+320 via bet365) ⭐⭐

🚀 Parlay odds: +59916 via FanDuel ($10 to win $5,991.60)

Bet $5, Win $200 in Bonus Bets

New customers only. Min. deposit $5+. Bet $5+ and win $200 in Bonus Bets, if your bet wins (within 72 hours). Bet does not have to win in AZ, CO, KS, NC, or TN.

Claim $200

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

💣 Best home run prediction today: MLB expert picks & prop bets

⚾ Elly De La Cruz (Reds) to hit a home run ⭐⭐⭐

Best odds: +575 via bet365 (bet $10 to win $57.50)

Bet $5, Get $150 in Bonus Bets Win or Lose*

*Deposit required. Mobile app only. Bonus Bets wager excluded from returns. T&Cs, time limits and exclusions apply. Gambling problem? Call 1-800-GAMBLER

Claim Now

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Elly De La Cruz is one of five current Cincinnati Reds hitters to have homered off Chicago Cubs righty Jameson Taillon, who has allowed at least one home run in nine of his 11 starts this season - including at least one in five straight and nine total over his last 23 1/3 innings.

De La Cruz is in his much better hitting split facing a right-handed pitcher than a southpaw. His OPS is 316 points higher against right-handed pitchers, and nine of his 11 home runs this year have come against righties.

The Reds star has just one home run in 11 career games at Wrigley Field, but this is great value on him to go deep again, especially if the wind is blowing out.

📊 Reds vs. Cubs odds

💡 More MLB expert picks today

Best home run predictions today
Yankees vs. Dodgers prediction
Shohei Ohtani vs. Aaron Judge player props

💵 Best MLB betting sites

Want to bet on baseball? Check out the best MLB betting sites and best sportsbook promos for today's games:

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Written By:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”