Athletics vs. Astros Prediction, Odds & Best Bets: Can Spot Starter Save Houston's Streak?

Houston returns home to welcome a slumping division rival after earning an unlikely sweep over Arizona, and my Athletics vs. Astros prediction expects the hosts to keep winning.

First pitch is set for 8:10 p.m. ET (MLB Network) from Daikin Park in Houston. The best sports betting sites list the Astros as -125 betting favorites to grow or maintain their lead atop the American League West.

My Athletics vs. Astros best bets expect some of the top featured hitters to stay hot against a familiar face, despite the pitcher donning new colors for this matchup.

• Athletics vs. Astros prediction: Astros to win (-125 via BetMGM) ⭐⭐⭐⭐
• Best Athletics vs. Astros player props: Jose Altuve Over 1.5 hits (+165 via DraftKings) ⭐⭐⭐

⚾ Athletics vs. Astros prediction & odds

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✅ Athletics vs. Astros prediction: Astros to win (-125 via BetMGM)

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These teams enter this game as polar opposites. The injury-riddled Astros have won four straight and are coming off a sweep in Arizona. Meanwhile, the A's have dropped five of six games since the All-Star break, including a blanking from Houston's noisy northern neighbors. My Athletics vs. Astros prediction favors the in-form group.

Former Athletics pitcher Jason Alexander takes the mound for the hosts tonight. While he's not exactly the master of his domain with an 8.40 ERA on the season, he was the king of the county in his lone start against the A's earlier this year. Alexander held his old teammates to three hits and two runs across six frames.

Houston's lineup - the most injured in the majors - might not impress on paper at the moment, but Joe Espada puts out a scrappy squad that somehow finds a way to win every night. Unlike George Costanza, these players don't come from a long line of quitters, nor were they raised to fail.

My Athletics vs. Astros best bet expects this trend to continue in the comfort of Houston's home ballpark. The best sports betting apps list the Astros as -125 favorites to win outright, a play we recommend at four stars of confidence.

💰 Best Athletics vs. Astros player props

✅ Best Athletics vs. Astros player prop: Jose Altuve Over 1.5 hits (+125 via DraftKings)

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Playing under the brightest lights in New York earns players catchy nicknames. Look no further than Derek Jeter, aka "The Captain," or Luis "Sevy" Severino for examples of this trend. Well, Jose Altuve - or "Daddy" to fans in the Bronx - has a track record of success against Sevy.

While Severino now sports new stripes in Sacramento with the Athletics, Altuve's dominance has been carrying over. The future Hall of Fame second baseman is hitting .302 across 43 at-bats against Severino during his career.

My best Athletics vs. Astros player prop features Altuve, who has logged five multi-hit games across his last 10 outings. A $10 winning wager on the superstar infielder at either Caesars or DraftKings would lead to $12.50 in profit.

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❓MLB betting FAQs

How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common. 

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.

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