College Football Week 12 Parlay Picks: 3 Predictions for Saturday’s Slate

Four top-25 teams suffered upsets in Week 11. Can we expect similar chaos again in Week 12? Read on for our college football Week 12 parlay picks.

Philip Wood

Last updated: November 16, 2022 5:11 AM EST • 3 min read

What bets are most likely to hit in Week 12 of the college football season? Read on to see our college football Week 12 parlay picks.

While just a handful of teams hold a chance to make the College Football Playoff, almost every school is still playing hard for something with just a few weeks remaining.

Whether teams are battling for a spot in a conference championship game or just trying to earn enough wins to become bowl eligible, the intensity is ramping up. That's led to some surprising results both straight up and against the spread.

For instance, four top-25 teams lost to unranked opponents in Week 11, while No. 25 Washington handed No. 6 Oregon its first defeat since Week 1.

Here are our college football Week 12 parlay picks (odds via DraftKings Sportsbook).\

Check out our college football picks roundup, top against-the-spread picks, games to watch, and top Over/Under bets for Week 12.

College Football Week 12 Parlay Picks

College Football Week 12 Parlay Predictions

Duke vs. Pittsburgh Over 52 (-110)

The Pittsburgh Panthers have given up just 16 points over their last two games while allowing only one touchdown. However, those matchups were against a Virginia Cavaliers offense averaging merely 17 points per game, and a Syracuse Orange unit that's been disappointing since Carlos Del Rio-Wilson took over as quarterback.

The Panthers are allowing 23.9 points per game overall. Now they're welcoming the Duke Blue Devils to town, who are averaging 33.7 points per contest. The Blue Devils have scored over 35 points in three of their last four games, and they've tallied 20-plus points in every game this season.

Prior to their solid defensive performances over the past two weeks, the Panthers had given up 29 points per game in their previous five contests. That defense was playing against much more complete offenses, and Duke’s unit is humming. Look for this game to end with both teams scoring in the high 20s or 30s.

Clemson -19 (-110)

The Clemson Tigers will be playing in the ACC Championship Game. Their chances of making the College Football Playoff are slim, but they won't stop playing like a national contender.

They now face the Miami Hurricanes at home. The Hurricanes are just 5-5, and they picked up only their second win against the spread in 2022 after beating Georgia Tech 35-14 in Week 11.

The Hurricanes may have looked good last week, but it’s going to take more than one game for them to prove they can compete with Clemson. Remember, in Week 10 the Hurricanes lost 45-3 at home to Florida State.

The Tigers have been in some tightly contested games, but they've been blowing out their weakest opponents. And the Hurricanes look like they don't belong on the same field when playing teams much better than them.

Washington State -4 (-110)

The Arizona Wildcats pulled off one of the biggest upsets of the season after taking down the UCLA Bruins as 20-point underdogs. The win ended a four-game losing streak, and it kept the Wildcats' hopes of a bowl game alive.

Now they'll take on the Washington State Cougars, a huge letdown spot for the Wildcats. Arizona wants to score a lot of points, but the Cougars are only allowing 19.8 per game.

Washington State has been playing tight games against some very good competition like Oregon and Utah. They've also managed to beat teams below their talent level rather easily. The Cougars could be looking ahead to a rivalry game against Washington next weekend. But they should still be able to do enough to handle a team that essentially won its Super Bowl in Week 11.

Where to Bet on College Football Week 12 Parlay Picks

Here are our top-rated sportsbooks:

College Football Week 12 parlay picks made 11/15/2022 at 5:26 p.m. ET

Written By:
Philip Wood

Phil has covered sports betting since 2016, and he has been with SportsBook Review since 2022. He previously hosted the College Football Pick 'Em podcast for CanesInsight.com. He is always looking for value, especially on lines that just seem too good to be true. His belief is that if a line doesn't make sense just assume oddsmakers know something you don't. He also loves in-season futures. There is so much value to be had as the public overreacts weekly. Bettors tend to forget just how long NFL and college football seasons are. After all, the Green Bay Packers were 2-5 in 2023 and they made it to the Divisional Round. When deciding where to bet, it comes down to value over everything. +100 is always better than -110. An alumnus of The U, Phil always holds out hope that the next head coach will be the one who turns the football program around. He is also a diehard Detroit Lions fan and is willing to forgive Dan Campbell for forgetting that a kicker can be useful.