Penn State vs. Ohio State Prediction & Opening Odds for College Football Week 10
In what was supposed to be a Big Ten heavyweight battle, my Penn State vs. Ohio State prediction breaks down the opening odds, with my early picks backing the No. 1 Buckeyes.
Could reshaped expectations for this game mean an opportunity for bettors in our college football predictions for Week 10? The action for Penn State vs. No. 1 Ohio State kicks off from Ohio Stadium in Columbus, Ohio, on Saturday at noon ET (FOX). Ohio State is a 20.5-point betting favorite.
🏈 Early Penn State vs. Ohio State prediction & betting preview
Stay ahead with the rest of our early college football picks for Week 10.
🌰 Ohio State -20.5 (-110) ⭐⭐⭐⭐
The dominant Buckeye defense should make life difficult on a Penn State offense that ranks outside the top 50 in FPI’s adjusted offensive efficiency, as Ohio State ranks sixth nationally in run defense (84.2 yards per game) and third in pass defense (141.2 yards per game).
Keeping pace with this large point spread could require the Nittany Lions to find success through the air, which should be difficult for Penn State’s 112th-ranked pass offense. The Buckeyes have won their home games by an average of 36.0 points per game, while Penn State’s average road ATS margin of -14.3 PPG is 8th-worst in FBS.
The top price at our best college football betting sites for Ohio State -20.5 comes from Caesars at -110. The implied probability at those odds is 52.38%, and a winning $10 bet would profit $9.09.
💡 More college football predictions for Week 10
Want more college football betting advice? Check out all of our college football analysis and expert predictions for every game this week.
📊 Live Penn State vs. Ohio State odds: Week 10
See the latest college football odds for every game in Week 10.
🔢 Penn State vs. Ohio State opening odds
- Moneyline: Penn State +900 | Ohio State -1600
- Spread: Penn State +3.5 (-110) | Ohio State -3.5 (-110)
- Over/Under: Over 50.5 (-110) | Under 50.5 (-110)
↔️ Penn State vs. Ohio State line movement
Obviously, the Penn State program’s fall from grace has moved this line significantly since early odds were available weeks before the matchup.
With the line at Ohio State -20.5 as of Monday, odds from our best sports betting sites are already up to -115 on the Buckeyes’ side. I wouldn’t be surprised to see this number slide beyond a three-touchdown margin, considering the Buckeyes’ ATS dominance this season.
🔍️ Find the best odds for every bet
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📈 Penn State vs. Ohio State trends & betting notes
- Ohio State is the only team in FBS without a loss against the spread (6-0-1 ATS)
- The Buckeyes boast an outright average margin of victory of 30.6 points per game, producing an average ATS margin of +8.2 PPG
- Ohio State ranks top 10 in the FBS in both pass defense and run defense
- Ohio State has beaten Penn State in eight straight matchups and hasn’t lost to the Nittany Lions in Columbus since 2011
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📺 How to watch Penn State vs. Ohio State
- Date: Saturday, Nov. 1
- Kickoff: Noon ET
- Where: Ohio Stadium (Columbus, Ohio)
- TV: FOX
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