College Football Opening Odds for Week 4: Betting Lines for Top-25 Matchups
π College football odds for Week 4
The opening college football odds for Week 4 are via FanDuel.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| No. 17 Texas Tech vs. No. 16 Utah | Utah -3.5 | Utah -166 | 57.5 |
| UAB vs. No. 15 Tennessee | Tennessee -39.5 | OFF | 67.5 |
| Oregon State vs. No. 6 Oregon | Oregon -34.5 | OFF | 57.5 |
| Kent State vs. No. 7 Florida State | Florida State -45.5 | OFF | 55.5 |
| No. 22 Auburn vs. No. 11 Oklahoma | Oklahoma -6.5 | Oklahoma -240 | 48.5 |
| Tulane vs. No. 13 Ole Miss | Ole Miss -12.5 | Ole Miss -400 | 60.5 |
| No. 21 Michigan vs. Nebraska | Michigan -1.5 | Michigan -125 | 44.5 |
| Purdue vs. No. 24 Notre Dame | Notre Dame -27.5 | Notre Dame -4500 | 54.5 |
| Temple vs. No. 18 Georgia Tech | Georgia Tech -24.5 | Georgia Tech -2800 | 52.5 |
| South Carolina vs. No. 23 Missouri | Missouri -12.5 | Missouri -550 | 46.5 |
| Florida vs. No. 4 Miami | Miami -7.5 | Miami -285 | 52.5 |
| No. 9 Illinois vs. No. 19 Indiana | Indiana -4.5 | Indiana -188 | 52.5 |
| Georgia State vs. No. 20 Vanderbilt | Vanderbilt -26.5 | Vanderbilt -4000 | 53.5 |
| SE Louisiana vs. No. 3 LSU | OFF | OFF | OFF |
| Sam Houston vs. No. 8 Texas | Texas -41.5 | OFF | 51.5 |
| Michigan State vs. No. 25 USC | USC -17.5 | USC -800 | 55.5 |
*-SE Louisiana vs. No. 3 LSU does not feature odds due to FCS opposition.
The Week 4 college football slate is loaded with premier games, including three different top-25 matchups that are must-watch. The college football opening odds for Week 4 include five games featuring ranked programs with a single-digit spread, as well as multiple rivalry games with the majority of teams beginning conference play.
The early betting lines for top-25 matchups include No. 16 Utah being favored over No. 17 Texas Tech, No. 11 Oklahoma being favored over No. 22 Auburn, and No. 19 Indiana being favored over No. 9 Illinois. Our college football predictions for Week 4 cover those three heavyweight matchups and much more.
π Texas Tech vs. Utah odds
- When: Saturday, Sept. 20
- Kickoff: Noon p.m. ET
- Where: Rice-Eccles Stadium (Salt Lake City)
- How to watch: FOX
Though this Big 12 battle is getting less attention than Auburn vs. Oklahoma, it may be the game that has the biggest impact on the College Football Playoff odds. Utah opened as a 4-point betting favorite with the line coming down to -3 in a matchup that pits the Utes' dynamic offense, led by QB Devon Dampier, against Texas Tech's $25-million roster. The winner will be in the driver's seat in the Big 12.
π UAB vs. Tennessee odds
- When: Saturday, Sept. 20
- Kickoff: 12:45 p.m. ET
- Where: Neyland Stadium (Knoxville, Tenn.)
- How to watch: SEC Network
π Oregon State vs. Oregon odds
- When: Saturday, Sept. 20
- Kickoff: 3 p.m. ET
- Where: Autzen Stadium (Eugene, Ore.)
- How to watch: Big Ten Network
π Kent State vs. Florida State odds
- When: Saturday, Sept. 20
- Kickoff: 3:30 p.m. ET
- Where: Doak Campbell Stadium (Tallahassee, Fla.)
- How to watch: ACC Network
π Auburn vs. Oklahoma odds
- When: Saturday, Sept. 20
- Kickoff: 3:30 p.m. ET
- Where: Memorial Stadium (Norman, Okla.)
- How to watch: ABC
This line is seeing a lot of movement early with Oklahoma opening as a 4.5-point betting favorite at our best college football betting sites before the line shifted to the Sooners -6.5. That's due in part to the public being all over Oklahoma after John Mateer led the program to a win over Michigan two weeks ago. This game also features former Oklahoma QB Jackson Arnold returning to Norman as Auburn's QB1.
π Tulane vs. Ole Miss odds
- When: Saturday, Sept. 20
- Kickoff: 3:30 p.m. ET
- Where: Vaught-Hemingway Stadium (Oxford, Miss.)
- How to watch: ESPN
π Michigan vs. Nebraska odds
- When: Saturday, Sept. 20
- Kickoff: 3:30 p.m. ET
- Where: Memorial Stadium (Lincoln, Neb.)
- How to watch: CBS, Paramount+
π Purdue vs. Notre Dame odds
- When: Saturday, Sept. 20
- Kickoff: 3:30 p.m. ET
- Where: Notre Dame Stadium (Notre Dame, Ind.)
- How to watch: NBC, Peacock
π Temple vs. Georgia Tech odds
- When: Saturday, Sept. 20
- Kickoff: 4:30 p.m. ET
- Where: Bobby Dodd Stadium (Atlanta)
- How to watch: The CW Network
π South Carolina vs. Missouri odds
- When: Saturday, Sept. 20
- Kickoff: 7 p.m. ET
- Where: Memorial Stadium (Columbia, Mo.)
- How to watch: ESPN
π Florida vs. Miami odds
- When: Saturday, Sept. 20
- Kickoff: 7:30 p.m. ET
- Where: Hard Rock Stadium (Miami Gardens, Fla.)
- How to watch: ABC
π Illinois vs. Indiana odds
- When: Saturday, Sept. 20
- Kickoff: 7:30 p.m. ET
- Where: Memorial Stadium (Bloomington, Ind.)
- How to watch: NBC
If there's a game you should do everything you can to not miss on Saturday, this is the one. It's a top-10 Illinois team taking on last year's surprise College Football Playoff team in Indiana, which is a 4-point betting favorite at home with the public fairly split on who to back. While Illinois is the higher-ranked program, Indiana has a dark horse Heisman Trophy odds contender in QB Fernando Mendoza. The winner in Bloomington will strongly bolster their CFP resume.
π Georgia State vs. Vanderbilt odds
- When: Saturday, Sept. 20
- Kickoff: 7:30 p.m. ET
- Where: FirstBank Stadium (Nashville, Tenn.)
- How to watch: ESPNU
π SE Louisiana vs. LSU odds
No odds available
- When: Saturday, Sept. 20
- Kickoff: 7:45 p.m. ET
- Where: Tiger Stadium (Baton Rouge, La.)
- How to watch: SEC Network
π Sam Houston vs. Texas odds
- When: Saturday, Sept. 20
- Kickoff: 8 p.m. ET
- Where: DKR-Texas Memorial Stadium (Austin, Texas)
- How to watch: SEC Network, ESPN+
π Michigan State vs. USC odds
- When: Saturday, Sept. 20
- Kickoff: 11 p.m. ET
- Where: Los Angeles Memorial Coliseum (Los Angeles)
- How to watch: FOX
π’ College football Week 4 odds and lines
There's an advantage to betting the early college football odds when attempting to beat the closing line. The closer you wait until kickoff to make your college football picks, the more difficult it becomes to identify edges and secure the best price on most sides or totals.
That's why it's important to start monitoring the college football opening odds each week as soon as possible. A proactive approach is the first step to long-term success.
βCollege football odds FAQs
How do college football spread odds work?
When betting on college football, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.
How do college football moneyline odds work?
When betting on college football, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.
Where can I find the best college football betting odds?
Shop around our best college football betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.
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