College Football Predictions Week 3: Best Bets & Odds for Top Matchups

Check out the latest college football predictions and odds for Week 3, including our best bets and expert picks for all the marquee games.
College Football Predictions 2025 Week 3: Odds & Best Bets for Marquee Games
Pictured: Georgia quarterback Gunner Stockton throws a pass against Austin Peay. Photo by Brett Davis via Imagn Images.

After a slower Week 2, our college football predictions for Week 3 highlight a much tastier slate with a few college football national championship odds contenders playing in marquee games.

All three of the must-watch matchups in Week 3 feature SEC programs, with Georgia vs. Tennessee, Florida vs. LSU, and Texas A&M vs. Notre Dame leading the way. But that's not all we get, as Rich Rodriguez returns to the Backyard Brawl and Cal freshman phenom Jaron-Keawe Sagapolutele takes on Minnesota after dark.

Don't miss any of our college football picks for those games, or the other top matchups in Week 3, as we break down the college football Week 3 odds.


🏈 College football predictions for Week 3

Here are all of our college football expert picks for Week 3, which we'll update throughout the week.

  • NC State vs. Wake Forest prediction (coming soon)
    • NC State vs. Wake Forest player props (coming soon)
    • NC State vs. Wake Forest anytime touchdown scorer predictions (coming soon)
  • Colorado vs. Houston prediction (coming soon)
    • Colorado vs. Houston player props (coming soon)
    • Colorado vs. Houston anytime touchdown scorer predictions (coming soon)
  • Kansas State vs. Arizona prediction (coming soon)
    • Kansas State vs. Arizona anytime touchdown scorer predictions (coming soon)
  • Oregon vs. Northwestern player props (coming soon)
  • Early Georgia vs. Tennessee prediction (coming soon)
    • Georgia vs. Tennessee prediction (coming soon)
    • Georgia vs. Tennessee player props (coming soon)
    • Georgia vs. Tennessee anytime touchdown scorer predictions (coming soon)
  • Pittsburgh vs. West Virginia player props (coming soon)
  • Early Florida vs. LSU prediction (coming soon)
    • Florida vs. LSU prediction (coming soon)
    • Florida vs. LSU player props (coming soon)
    • Florida vs. LSU anytime touchdown scorer predictions (coming soon)
  • Early Texas A&M vs. Notre Dame prediction
    • Texas A&M vs. Notre Dame prediction (coming soon)
    • Texas A&M vs. Notre Dame player props (coming soon)
  • Minnesota vs. California player props (coming soon)

💰 College football odds & expert picks: Week 3

Here are the latest college football odds for every Week 3 game via the best college football betting sites, which update live in real time. 

📊 NC State vs. Wake Forest odds

  • Date: Thursday, Sept. 11
  • Kickoff: 7:30 p.m. ET
  • Location: Allegacy Federal Credit Union Stadium (Winston-Salem, N.C.)
  • How to watch: ESPN

📊 Colorado vs. Houston odds

  • Date: Friday, Sept. 12
  • Kickoff: 7:30 p.m. ET
  • Location: TDECU Stadium (Houston, Texas)
  • How to watch: ESPN

📊 Kansas State vs. Arizona odds

  • Date: Friday, Sept. 12
  • Kickoff: 9 p.m. ET
  • Location: Arizona Stadium (Tucson, Ariz.)
  • How to watch: FOX

📊 Oregon vs. Northwestern odds

  • Date: Saturday, Sept. 13
  • Kickoff: Noon ET
  • Location: Martin Stadium (Evanston, Ill.)
  • How to watch: FOX

📊 Georgia vs. Tennessee odds

  • Date: Saturday, Sept. 13
  • Kickoff: 3:30 p.m. ET
  • Location: Neyland Stadium (Knoxville, Tenn.)
  • How to watch: ABC
  • Early pick: Under 50.5 (-110 via bet365)

Though Tennessee is known for Josh Heupel's passing attack, it's the Volunteers' defense that carried them to the CFP last year. It once again looks poised to be among the best in the country - the unit ranks No. 6 in SP+ - and Gunner Stockton might have some hiccups against it. The same goes for Joey Aguilar against Kirby Smart's ferocious dawgs. Georgia is ranked No. 3 in SP+ on defense.


📊 Pittsburgh vs. West Virginia odds

  • Date: Saturday, Sept. 13
  • Kickoff: 3:30 p.m. ET
  • Location: Milan Puskar Stadium (Morgantown, W.V.)
  • How to watch: ESPN
  • Early pick: West Virginia +4.5 (-110 via bet365)

Rich Rodriguez's return to the Backyard Brawl could be epic with the Mountaineers' rushing attack looking ready to run wild behind Jaheim White. So while Pittsburgh has a star of its own in Desmond Reid, these two teams are similarly talented - both rank between No. 35 and No. 60 in SP+. Given that this game is in Morgantown, Rich Rod's West Virginia squad could have the crowd singing Country Roads by the time the clock hits zero.


📊 Florida vs. LSU odds

  • Date: Saturday, Sept. 13
  • Kickoff: 7:30 p.m. ET
  • Location: Tiger Stadium (Baton Rough, La.)
  • How to watch: ABC
  • Early pick: LSU -9.5 (-110 via bet365)

Can Billy Napier and DJ Lagway prove the Gators are for real this year?  They didn't against South Florida, so it's hard to imagine it happening in Death Valley at night. LSU looks ready to finally win an SEC Championship under Brian Kelly behind the play of Garrett Nussmeier and Harold Perkins Jr. LSU's defense should be the difference with so many of its transfers hitting the ground running.


📊 Texas A&M vs. Notre Dame odds

Mike Elko has similarly built Texas A&M as Marcus Freeman has built Notre Dame. Both teams play hard-nosed defense and, theoretically, want to run the ball. However, the Fighting Irish's offensive line looks like an issue that could negate Jeremiyah Love's talent against the Aggies. Meanwhile, Marcel Reed has Texas A&M ranked No. 19 in SP+ on offense. This should be a closer game than last year.


📊 Minnesota vs. California odds

  • Date: Saturday, Sept. 13
  • Kickoff: 10:30 p.m. ET
  • Location: California Memorial Stadium (Berkeley, Calif.)
  • How to watch: ESPN

💡 College football expert picks: Week 3

  • College football picks against the spread Week 3 (coming soon)
  • College football upsets picks Week 3 (coming soon)
  • College football trends that matter Week 3 (coming soon)
  • College football moneyline parlay Week 3 (coming soon)
  • College football player props Week 3 (coming soon)
  • College football best bets Week 3 (coming soon)
  • College football predictions Week 3 (coming soon)
  • College football anytime touchdown scorer predictions Week 3 (coming soon)
  • College football AI predictions for Week 3 (coming soon)

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