College Football Predictions Week 2: Picks & Odds for Marquee Games
After a week full of fluffy non-conference matchups for the top college football championship odds contenders, the level of difficulty increases significantly during a strong Week 2 slate.
Using our top college football betting sites, we're breaking down the loaded slate with our college football Week 2 odds and predictions. There are always plenty of college football player props to add to the fun.
The biggest game of the week is a showdown between two college football playoff odds contenders, with Texas taking on Michigan.
But that's not the only interesting matchup featuring an AP top-25 program. Alabama looks to handle business against South Florida after struggling last year with the Bulls - a game featured in our Week 2 college football expert picks.
The headline-grabbing game is the rematch between Nebraska and Colorado. Shedeur Sanders is a Heisman Trophy odds favorite, but the Cornhuskers have a talented young QB of their own.
College football picks & predictions Week 2
- Texas vs. Michigan prediction
- Northern Illinois vs. Notre Dame prediction
- Baylor vs. Utah prediction
- Iowa State vs. Iowa prediction
- Tennessee vs. NC State prediction
- South Florida vs. Alabama prediction (coming soon)
- Colorado vs. Nebraska prediction (coming soon)
- Colorado vs. Nebraska player props (coming soon)
- Shedeur Sanders player props (coming soon)
- Texas Tech vs. Washington State prediction (coming soon)
- Mississippi State vs. Arizona State prediction (coming soon)
Don't miss the rest of our Week 2 college football picks.
College football odds for Saturday
Texas vs. Michigan odds
Prediction: Texas -7 (-112 via DraftKings) vs. Michigan ⭐⭐⭐
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Pick made by Mike Spector
- When: Saturday, Sept. 7 (noon ET)
- Where: Michigan Stadium (Ann Arbor, Mich.)
- How to watch: FOX
- Moneyline: Texas (-285) | Michigan (+230)
- Spread: Texas -7.5 (-110) | Michigan +7.5 (-110)
- Total: 43.5 (-110/-110)
This is the game of the week with both teams ranked in the top 10. But Texas blew out Colorado State in Week 1 while Michigan struggled against Fresno State. Even with the Bulldogs being much better than the Rams in the Mountain West, the Wolverines' offense was alarming. The line could balloon to as much as -9.5 for the Longhorns by Saturday.
Northern Illinois vs. Notre Dame odds
Prediction: Northern Illinois +28.5 (-112 via FanDuel) ⭐⭐⭐⭐
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Pick made by Mike Spector
- When: Saturday, Sept. 7 (3:30 p.m. ET)
- Where: Notre Dame Stadium (Notre Dame, Ind.)
- How to watch: NBC, Peacock
- Moneyline: OFF
- Spread: Northern Illinois +28.5 (-112) | Notre Dame -28.5 (-108)
- Total: 45.5 (-108/-112)
Don't sleep on Northern Illinois as a MAC Championship odds contender, especially with how Thomas Hammock's team looked in Week 1. While Marcus Freeman's defense is legit and new QB Riley Leonard is an X-factor with his running, Notre Dame is coming off a physical win against Texas A&M. If this line moves, I think it will be in NIU's direction.
Baylor vs. Utah odds
Prediction: Utah -14.5 (-110 via bet365) ⭐⭐⭐⭐
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Pick made by Phil Wood
- When: Saturday, Sept. 7 (3:30 p.m. ET)
- Where: Rice-Eccles Stadium (Salt Lake City)
- How to watch: FOX
- Moneyline: Baylor (+470) | Utah (-650)
- Spread: Baylor +14 (-110) | Utah -14 (-110)
- Total: 53 (-110/-110)
It might be Dave Aranda's last season if he can't get things turned around at Baylor. So playing a conference game against the Big 12 Championship odds favorite in Week 2 is a tall task. Cam Rising returned to Utah's lineup last week and diced up Southern Utah. I think this line could move a point or two more toward the Utes.
Iowa State vs. Iowa odds
Prediction: Iowa State +3.5 (-115 via bet365) ⭐⭐⭐
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Pick made by Phil Wood
- When: Saturday, Sept. 7 (3:30 p.m. ET)
- Where: Kinnick Stadium (Iowa City, Iowa)
- How to watch: CBS, Paramout+
- Moneyline: Iowa State (+114) | Iowa (-135)
- Spread: Iowa State +2.5 (-108) | Iowa -2.5 (-112)
- Total: 35.5 (-108/-112)
The battle for the Cy-Hawk Trophy will be a good one with both of these teams expected to have top-notch defenses this season. New Iowa offensive coordinator Tim Lester helped the Hawkeyes look functional on offense last week, but that was against an FCS program. Iowa State is better than its Week 1 performance against North Dakota. This line shouldn't move.
Tennessee vs. NC State odds
Prediction: Tennessee -9 (-110 via DraftKings) vs. NC State ⭐⭐⭐⭐
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Pick made by Brenden Schaeffer
- When: Saturday, Sept. 7 (7:30 p.m. ET)
- Where: Bank of America Stadium, Charlotte
- How to watch: ABC
- Moneyline: Tennessee (-345) | NC State (+275)
- Spread: Tennessee -10 (-110) | NC State +10 (-110)
- Total: 60.5 (-112/-108)
South Florida vs. Alabama odds
- When: Saturday, Sept. 7 (7 p.m. ET)
- Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
- How to watch: ESPN
- Moneyline: OFF
- Spread: South Florida +31 (-110) | Alabama -31 (-110)
- Total: 63.5 (-112/-108)
Last year Alabama beat South Florida by a modest 17-3 score, and Jalen Milroe was the third-string QB for the game. Now Milroe's a Heisman contender and Kalen DeBoer is coaching the Crimson Tide. The Bulls have a star QB in Byrum Brown, but their defense is going to be an issue. Alabama beat Western Kentucky 63-0 in Week 1. This line could be -34 by kick.
Colorado vs. Nebraska odds
- When: Saturday, Sept. 7 (7:30 p.m. ET)
- Where: Memorial Stadium (Lincoln, Neb.)
- How to watch: NBC, Peacock
- Moneyline: Colorado (+215) | Nebraska (-265)
- Spread: Colorado +7.5 (-115) | Nebraska -7.5 (-105)
- Total: 57.5 (-112/-108)
When Colorado beat Nebraska 36-14 in Boulder last season it was at the height of Deion Sanders mania. But the Cornhuskers should be much more competitive in Matt Rhule's second season. Led by freshman QB Dylan Raiola, Nebraska killed UTEP last week while the Buffaloes struggled with North Dakota State. However, I think this will be more like -6.5.
Texas Tech vs. Washington State odds
- When: Saturday, Sept. 7 (10 p.m. ET)
- Where: Gesa Field (Pullman, Wash.)
- How to watch: FOX
- Moneyline: Texas Tech (+105) | Washington State (-125)
- Spread: Texas Tech +2 (-112) | Washington State -2 (-108)
- Total: 65.5 (-112/-108)
It's the Mike Leach bowl in Pullman between two teams that scored a lot and allowed a lot of scoring to FCS programs in Week 1. Texas Tech needed OT and a 2-point conversion stop to beat Abilene Christian. Washington State beat Portland State 70-30. Cougars QB John Mateer can toast the Red Raiders in a high-scoring game. This could move to -3 by kick.
Mississippi State vs. Arizona State odds
- When: Saturday, Sept. 7 (10:30 p.m. ET)
- Where: Mountain America Stadium (Tempe, Ariz.)
- How to watch: ESPN
- Moneyline: Mississippi State (+200) | Arizona State (-245)
- Spread: Mississippi State +6.5 (-112) | Arizona State -6.5 (-108)
- Total: 59.5 (-110/-110)
These are supposed to be two of the worst Power 4 teams in the country this season. Arizona State's dealing with all kinds of sanctions and Mississippi State is rebuilding under new coach Jeff Lebby. The Sun Devils are coming off a surprising blowout of Wyoming and should remain between -5.5 and -6.5.
College football picks roundup: Week 2
- College football Week 2 upset picks
- College football Week 2 parlay picks
- Big Ten predictions
- SEC predictions
- Big 12 predictions
- College football Week 2 predictions & best bets for Saturday
- College football Week 2 player props
- College football Week 2 expert picks
College football betting odds pages
Here are our best college football betting sites:
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- BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
- bet365 Bonus Code: SBRBONUS | Read our bet365 Review
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
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