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Tennessee running back Dylan Sampson runs with the ball against Chattanooga. We're backing Sampson in our Week 2 college football expert picks.
Tennessee running back Dylan Sampson runs with the ball against Chattanooga. Photo by Brianna Paciorka/News Sentinel/USA TODAY NETWORK via Imagn.

With several AP top 25 teams playing in high-profile games in Week 2, the College Football Playoff odds are bound to see some major movement.

The marquee game of our college football expert picks this week is the matchup between two college football championship odds contenders when Texas heads to Michigan.

But that's not the only one of our Week 2 college football predictions that could have an impact on the Heisman Trophy odds.

College football expert picks for Week 2

College football odds as of Friday and subject to change. See all of our college football picks for more on this week's top matchups.

Rob PaulC Jackson Cowart
Texas vs. MichiganTexas -7 (-110 via bet365)Under 42.5 (-110 via BetMGM)
Iowa State vs. IowaUnder 35.5 (-108 via FanDuel)Iowa State Under 16.5 points (-110 via Caesars)
South Florida vs. AlabamaByrum Brown 40+ rushing yards (+185 via DraftKings)Over 64 (-110 via bet365)
Kansas vs. IllinoisKaden Feagin 80+ rushing yards (+120 via DraftKings)Kansas -4.5 (-110 via bet365)
Tennessee vs. NC StateDylan Sampson Over 69.5 rushing yards (-103 via Caesars)Tennessee -8.5 (-110 via DraftKings)
Utah State vs. USCZachariah Branch Over 65.5 receiving yards (-115 via BetMGM)Miller Moss Over 333.5 passing yards (-115 via BetMGM)

Top picks for Week 2

Texas vs. Michigan prediction: Texas -7 ⭐⭐⭐⭐

This line should probably be more like -8.5. Michigan is a completely different team this year and struggled with Fresno State while Texas blew out Colorado State.

I don't expect a ton of points, but Texas won't need it with the Wolverines sitting 56th in SP+ on offense after Week 1. A $10 winning bet pays a $9.09 profit.

Best odds: -110 via bet365 | Implied probability: 52.38%

–– Rob Paul (SBRTwitter/X)

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Texas vs. Michigan prediction: Under 42.5 ⭐⭐⭐⭐

I would also lean toward Texas in this game, but I have much more conviction about the Under - especially with this outlier number from BetMGM just above a key number.

Michigan's offense has legitimate concerns with former walk-on Davis Warren at the helm, but this defense might be the best in the country as it welcomes Texas to one of college football's most raucous environments.

Best odds: -110 via BetMGM | Implied probability: 52.38%

–– C Jackson Cowart (SBRTwitter/X)

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Iowa State vs. Iowa prediction: Iowa State Under 16.5 points ⭐⭐⭐⭐⭐

Things always get wonky with the Cy-Hawk Trophy on the line, but one thing has remained the same: the Cyclones consistently struggle to score.

Iowa State has averaged 16.2 points in the last 10 meetings - a 41-point outburst skews that number a bit - while Iowa has allowed fewer than 17 points in 15 of its last 17 home games.

Best odds: -110 via Caesars | Implied probability: 52.38%

–– C Jackson Cowart (SBRTwitter/X)

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South Florida vs. Alabama prediction: Byrum Brown 40+ rushing yards ⭐⭐⭐⭐

It's shocking to see our top college football betting sites so down on Byrum Brown's rushing yards. Last season, he ran for 92 yards against Nick Saban's Alabama defense and hit 40 yards in 10 of 13 games.

Brown is a dynamic runner who led all QBs in rushing yards after contact last season (723), per PFF. A $10 winning bet on this prop pays an $18.50 profit.

Best odds: +185 via DraftKings | Implied probability: 35.09%

–– Rob Paul (SBRTwitter/X)

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Kansas vs. Illinois prediction: Kansas -4.5 ⭐⭐⭐⭐

It feels like the market is still sleeping on Kansas, which went 9-4 last year and features one of the best QB-RB duos in the country in Jalon Daniels and Devin Neal.

The Jayhawks jumped out to a 21-0 lead over Illinois last year in an eventual 11-point win. With this line as high as -5.5 via FanDuel, I love the value at -4.5 via bet365.

Best odds: -110 via bet365 | Implied probability: 52.38%

–– C Jackson Cowart (SBRTwitter/X)

Tennessee vs. NC State prediction: Dylan Sampson Over 69.5 rushing yards ⭐⭐⭐⭐

NC State's defense struggled with Western Carolina. Tennessee is loaded with talent and the Wolfpack will likely sell out to stop Nico Iamaleava. That'll give Dylan Sampson light boxes to exploit.

He ran for 124 yards on just 12 carries last week, and his speed is a game-changer in Josh Heupel's veer and shoot offense. A $10 winning bet pays a $9.71 profit.

Best odds: -103 via Caesars | Implied probability: 50.74%

–– Rob Paul (SBRTwitter/X)

College football betting odds pages

Here are our best college football betting sites:

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