USC vs. Indiana Expert Picks: Colleg Football Predictions (Nov. 14)

Our experts weigh in on USC vs. Indiana, and see their selections, betting odds, and reasons for backing each pick.
Southern California Trojans quarterback Jayden Maiava (14) moves out to pass as he is featured in our USC vs. Indiana expert picks.
Pictured: Southern California Trojans quarterback Jayden Maiava (14) moves out to pass as he is featured in our USC vs. Indiana expert picks. Photo by Gary A. Vasquez-Imagn Images
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The No. 15 USC Trojans and No. 6 Indiana Hoosiers meet Saturday in a highly anticipated Big Ten showdown between two ranked college football programs as we break down our USC vs. Indiana expert picks. Kickoff is scheduled for 3:30 p.m. ET at Memorial Stadium in Bloomington, Indiana, with the game airing nationally on CBS and streaming on Paramount+. 


USC vs. Indiana expert picks: College football Saturday

See all of our experts' college football picks for Week 11 based on the latest college football odds.

Expert Pick
Mike Spector USC +7.5 (-115 via FanDuel)
Brenden Schaeffer Under 50.5 (-110 via FanDuel)

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Mike Spector's pick: USC +7.5 (-107)

Indiana has a chance to add to its list of things never done before in program history, as USC is the only Big Ten team the Hoosiers have never beaten. It is a rightful home favorite in this matchup, but its offense has struggled for four games now with an average of 14.3 points per game in regulation in that span. 

Quarterback Josh Hoover had a bye week to help nurse an arm injury that forced him out of second-half action in the last game against Minnesota. But if he isn’t 100%, that hurts a run-heavy offense that opens up deep throws for a passing game that ranks third in the nation in yards per completion (15.2). It also makes it less likely that Indiana can exploit USC’s weakness of allowing nearly eight yards per pass attempt (117th).

Indiana’s recent offensive struggles were exacerbated by its quarterbacks’ sub-60% completion percentage (100th), as it couldn’t utilize its running game in longer down-and-distances. That issue should be highlighted further by a USC defense that allows just 2.1 yards after contact per carry.

See Mike Spector's full analysis in his USC vs. Indiana prediction.

Brenden Schaeffer's pick: Under 50.5 (-110)

Though Indiana hasn’t boatraced teams this season the way the Hoosiers did a year ago, we’ve seen Curt Cignetti’s group win close by leaning on its defense. That could lend toward a lower-scoring affair than is typical for USC - although games involving the Trojans are still just 4-5 on Overs this season.

Indiana’s games are 3-6 on Overs. Indiana hasn’t played in a game that saw even as many as 40 total points in any of its last four contests.

See Brenden Schaeffer's full analysis in his USC vs. Indiana same-game parlay.


Live USC vs. Indiana odds

See the latest odds movement and more on our USC vs. Indiana matchup page.


USC vs. Indiana weather

The forecast for Saturday's USC vs. Indiana matchup in Bloomington calls for clear skies and chilly temperatures around 45–48 degrees at the 3:30 p.m. ET kickoff, with virtually no chance of rain. Winds are expected to remain light out of the northwest at 7–10 mph, meaning weather conditions should have minimal impact on either team's passing or kicking game.


Latest USC vs. Indiana injuries

USC:

  • Terrell Anderson, WR - Questionable

Indiana:

  • Josh Hoover, QB - Questionable

How to watch USC vs. Indiana: College football Saturday

  • Date: Saturday, Nov. 14
  • Kickoff: 3:30 p.m. ET
  • Location: Memorial Stadium (Bloomington, Ind.)
  • TV/Streaming: CBS