USC vs. Indiana Prediction: Week 11 Odds, Picks & Best Bet (Nov. 14)
No. 9 Indiana hosts No. 18 USC in the only matchup of two ranked Big Ten teams this week, and my USC vs. Indiana prediction takes a look at why laying more than a touchdown with the Hoosiers is worrisome when quarterback Josh Hoover isn’t 100% healthy.
Kickoff from Memorial Stadium in Bloomington is set for 3:30 p.m. ET on Saturday (CBS). The Hoosiers are 7.5-point betting favorites and O/U is at 50.5.
USC vs. Indiana picks & predictions
See all of our experts' college football picks for Week 11 based on the latest college football odds.
| Pick | Odds | Bet size |
|---|---|---|
| USC +7.5 | -115 via FanDuel | 1 unit to profit 0.87 units |
| Under 50.5 | -110 via BetMGM | 1 unit to profit 0.91 units |
Picks submitted: Nov. 11 at 2 p.m. ET. Odds subject to change.
Total wagered: 2 units | Profit if all picks win: 1.78 units
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USC vs. Indiana prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
USC +7.5 (-115 via FanDuel)
Indiana has a chance to add to its list of things never done before in program history, as USC is the only Big Ten team the Hoosiers have never beaten. It is a rightful home favorite in this matchup, but its offense has struggled for four games now with an average of 14.3 points per game in regulation in that span.
Quarterback Josh Hoover had a bye week to help nurse an arm injury that forced him out of second-half action in the last game against Minnesota. But if he isn’t 100%, that hurts a run-heavy offense that opens up deep throws for a passing game that ranks third in the nation in yards per completion (15.2). It also makes it less likely that Indiana can exploit USC’s weakness of allowing nearly eight yards per pass attempt (117th).
Indiana’s recent offensive struggles were exacerbated by its quarterbacks’ sub-60% completion percentage (100th), as it couldn’t utilize its running game in longer down-and-distances. That issue should be highlighted further by a USC defense that allows just 2.1 yards after contact per carry.
📡 SBR Edge: Indiana's poor special teams
Indiana hasn't helped itself in the kicking department, connecting on just 13 of 20 field goals, including making one of five from 50-plus yards.
USC can keep the chains moving from anywhere
Curt Cignetti’s teams are 27-1 when totaling four or more sacks, and this year’s pass rush ranks fifth nationally with 32 sacks on the year. But unlike other teams that fold on third-and-long consistently against Indiana’s defense, USC is one of the best teams in the country in that split, converting 38% of the time.
In a road environment like this I’d also tend to worry about turnovers flipping a game instantly. But the Hoosiers defense is tied for 92nd with just nine takeaways on the year.
Play to: +7 (-110), pass at +6.5 or lower
Score prediction: Indiana 24, USC 21
Live USC vs. Indiana odds
See the latest odds movement and more on our USC vs. Indiana matchup page.
USC vs. Indiana opening odds
- Moneyline: USC +220 | Indiana -275
- Spread: USC +7 (-105) | Indiana -7.5 (-112)
- Over/Under: Over 49.5 (-110) | Under 49.5 (-110)
USC vs. Indiana weather
Temperatures are forecasted in the mid 40s with mostly sunny skies, a 5% chance of precipitation, and winds light at 8 mph NW.
Latest USC vs. Indiana injuries
USC:
- Terrell Anderson, WR - Questionable
Indiana:
- Josh Hoover, QB - Questionable
How to watch USC vs. Indiana: Week 11
- Date: Saturday, Nov. 14
- Kickoff: 3:30 p.m. ET
- Location: Memorial Stadium (Bloomington, Ind.)
- TV/Streaming: CBS
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