Panthers vs. Saints Prediction: Week 10 Odds, Picks & Best Bet (Nov. 15)
Last Updated: November 14, 2026 12:00 PM EST • 3 minute read X Social Google News Link
My best Panthers vs. Saints prediction highlights why the Panthers' offense is going to lead Carolina to an upset against one of the worst defenses in the NFL. Though the Panthers haven't topped 21 points during their three-game losing streak, the Saints are allowing 27.0 points per game.
The Saints are favored by 2.5 points ahead of Sunday's 1 p.m. ET game at Caesars Superdome in New Orleans. The game will air on FOX and stream on FOX One.
Panthers vs. Saints picks & predictions
See all of our experts' NFL picks for Week 10 based on the latest NFL odds.
| Pick | Odds | Bet size |
|---|---|---|
| Panthers +2.5 | -110 via bet365 | 2.5 units to profit 2.27 units |
| Under 48.5 | -105 via FanDuel | 0.5 units to profit 0.48 units |
Picks submitted: Nov. 12 at 7:45 p.m. ET. Odds subject to change.
Total wagered: 3 units | Profit if all picks win: 2.75 units
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Panthers vs. Saints prediction & best bet
Panthers +2.5 (-110 via bet365)
The Saints are averaging 325.8 yards per game, but they're too reliant on their passing attack to be trusted in this matchup. The Saints are averaging 230.5 passing yards per game, which ranks 14th in the NFL. However, they're only averaging 6.4 yards per attempt, which ranks 25th.
The Panthers' pass defense has been solid, allowing just 211.5 yards per game. That's the ninth-best average in the league. Even more impressive, the Panthers are allowing just 6.1 yards per pass attempt and 9.6 yards per completion. Both of those marks rank in the top seven in the NFL.
If the Saints struggle through the air like these stats suggest they will, they will need to turn to their 26th-ranked rushing attack, which is averaging just 95.3 yards per game. The Panthers are allowing 133.4 rushing yards per contest, but they should be able to hold up against an offense averaging just 3.8 yards per carry this season.
📡 SBR Edge
The Panthers are 3-1 in games where they score at least 25 points. The Saints are 1-4 when allowing 23 or more points.
Panthers' passing attack finally bounces back
After averaging 309.8 yards per game through the first five weeks, Bryce Young has managed just 216 passing yards per game over the last three weeks. While he threw for 276 yards last week, he's been held to 209 yards or fewer in his other two games during that span.
The good news for Young is that the Saints' pass defense ranks 28th, allowing 236.6 yards per game. Over their last three games, the Saints have allowed 277.3 passing yards per game, despite facing Shedeur Sanders, Aaron Rodgers, and JJ McCarthy during that stretch.
With the passing attack firing on all cylinders, the Saints' defense should drop back and open up running lanes for Chuba Hubbard. Hubbard has rushed for at least 79 yards in five of his last six games, topping 100 yards twice during that span. The Saints are allowing 133.9 rushing yards per game and 4.5 yards per carry.
Play to: Panthers -2.5 at -110
Score prediction: Panthers 27, Saints 21
Live Panthers vs. Saints odds
See the latest odds movement and more on our Panthers vs. Saints page.
Panthers vs. Saints opening odds
- Moneyline: Panthers -118 | Saints -102
- Spread: Panthers -1.5 (+100) | Saints +1.5 (-120)
- Over/Under: Over 46.5 (-110) | Under 46.5 (-110)
Panthers vs. Saints weather
This game will be played in a dome.
Latest Panthers vs. Saints injuries
How to watch Panthers vs. Saints: Week 10
- Date: Sunday, Nov. 15
- Kickoff: 1 p.m. ET
- Location: Caesars Superdome (New Orleans)
- TV/Streaming: FOX/FOX One
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