College Football Player Prop Picks Week 5: Best College Prop Bets This Week

This is the best slate we've had all season, and my college football player prop picks for Week 5 focus on some of the biggest names taking the field Saturday with my best college football picks covering the five can't-miss matchups.

From USC's Big Noon Kickoff with Illinois to Penn State's white out against Oregon to Alabama and Georgia's rematch of last year's instant classic, my college football predictions for Week 5 have you covered with the best player prop for each must-watch game.

🏈 College football player prop picks: Week 5

College football player props based on the latest college football odds for Week 5; subject to change.

💰 Best college player prop bets

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⬆️ Jayden Maiava, QB, USC: Over 269.5 passing yards (-114) ⭐⭐⭐⭐

It's not Heisman Trophy odds favorites Fernando Mendoza, Dante Moore, or Carson Beck who lead the country in QBR (95.5) heading into Week 5. That honor belongs to USC's Jayden Maiava, who has taken a huge leap in his first full season as Lincoln Riley's starter - reminding some of another No. 14 who once led the Trojans.

While Maiava has a long way to go to be a top-five pick like Sam Darnold was, he's trending in the right direction. The former breakout freshman at UNLV ranks top 10 in the country in passing yards (1,223), No. 1 in yards per attempt (12.7), and No. 14 in adjusted completion rate (79.8%). He should have no trouble dicing up an Illinois defense that ranks No. 75 in EPA per pass and couldn't stop Mendoza last week.

Maiava has thrown for Over 269.5 passing yards in three of four games this season - thanks in part to having one of the best receivers in the country in Makai Lemon - while averaging 305.7 passing yards per game. If he can top this number again, a $10 bet pays an $8.77 profit.

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⬆️ Jeremiah Smith, WR, Ohio State: Over 90.5 receiving yards (-114) ⭐⭐⭐⭐⭐

After knocking off the preseason college football national championship odds favorites in Week 1, Ohio State has had it easy. The Buckeyes followed up the win over Texas by beating Grambling State and Ohio by a combined score of 107-9.

That makes this road game against Washington the defending champions' first real test in nearly a month ... and Jeremiah Smith should be ready to shine.

While Smith had just 43 yards against a Texas defense among the best in the sport, he's put up 14 receptions for 272 receiving yards in his last two games. The sophomore looks like he could be thriving on Sundays right now at just 19 years old - he ranks top 10 in the country in yards per route run (4.44).

Smith should pose a problem for a Huskies' defense that ranks No. 70 in EPA per pass and could be without top cornerback Tacario Davis on Saturday. And if Ohio State's star can go for 91-plus receiving yards for the ninth time in his career, a $10 bet pays an $8.77 profit.

⬇️ Garrett Nussmeier, QB, LSU: Under 286.5 passing yards (-114) ⭐⭐⭐⭐

Is LSU good? Is Garrett Nussmeier overrated? Is Lane Kiffin's daughter really rooting for Ole Miss instead of her boyfriend Whit Weeks' team? All these questions (and more) will be answered in the Magnolia Bowl on Saturday.

Obviously, our best college football betting sites think Nussmeier is set to have his best game yet with this 286.5 passing yards prop ... or do they think LSU will be playing from behind all afternoon?

I'm not sure, but either way I'm fading Nussmeier, who has yet to throw for more than 273 yards in a game this season and hasn't gone for more than 237 against any of the Tigers' three FBS opponents. While I do think Nussmeier is one of the most pro-ready QBs in the country, LSU's offense has been discombobulated.

LSU ranks outside of the top 45 in EPA per pass on offense, and this Ole Miss defense is no joke, ranking No. 18 in EPA per pass and allowing just 166.3 passing yards per game. If the Nuss Bus is held Under 286.5 passing yards for the fifth straight game, a $10 bet pays an $8.77 profit.

⬆️ Nicholas Singleton, RB, Penn State: Over 64.5 rushing yards (-114) ⭐⭐⭐⭐

In a matchup that pits two of the three biggest College Football Playoff odds favorites against each other - and the top two ranked teams by SP+ - expectations couldn't be higher for Penn State at home. Nittany Lions' head coach James Franklin desperately needs to prove he can win a big game, and to do so, he'll need to ride his run game.

While Penn State has yet to play a Power Four opponent yet this season, QB Drew Allar hasn't been impressive and this Oregon defense is built to stop the pass. However, the Ducks are just No. 54 in EPA per rush on defense and have allowed 144-plus rushing yards in two of four games this season.

That's why Nicholas Singleton, who ran for 105 yards against the Ducks in the Big Ten Championship last season, is the key to a win and is poised to go Over 64.5 rushing yards for the seventh time in eight games - if he does, a $10 bet pays an $8.77 profit.

He's a better bet to go Over his rushing yards line than Kaytron Allen (68.5), too, having played more snaps and taken more carries than his running mate this season.

⬆️ Ty Simpson, QB, Alabama: Over 1.5 passing TDs (-110) ⭐⭐⭐⭐⭐

The perception around Ty Simpson entering Alabama's matchup with Georgia is that he's not good enough to lead the Crimson Tide back to the top of the CFP rankings. But don't let the struggles of a young QB on the road against a top-10 team be his death sentence. After all, Simpson had never thrown more than five passes in a game against a P4 team prior to that loss to Florida State.

Since then, he's looked like one of the best quarterbacks in the country, ranking top 15 in QBR (81.5) and adjusted completion rate (82.4%) while having one of the lowest turnover-worthy play rates (0.9%). Simpson is a field general and one of the most efficient passers in the country, and this Kirby Smart defense ain't what it used to be ... it sits just No. 97 in EPA per pass.

Simpson is well equipped to put up big numbers against the Bulldogs, throwing to one of the nation's top pass-catching duos in Ryan Williams and Germie Bernard. He's managed two-plus touchdown passes in all three of his games this season, and if he goes Over 1.5 again, a $10 bet pays a $9.09 profit.

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