Skip to main content

College Football Predictions Week 5 2023: Picks & Odds for Marquee Games

Esten McLaren

Last Updated: September 30, 2023 3:52 PM EDT • 1 min 8 sec read.

Barion Brown #7 of the Kentucky Wildcats runs with the ball as we look at our best college football predictions for Week 5
Barion Brown #7 of the Kentucky Wildcats runs with the ball in the first half of a game against the Vanderbilt Commodores at FirstBank Stadium on September 23, 2023 in Nashville, Tennessee. Photo by Carly Mackler/Getty Images via AFP.

Set yourself up for a successful betting week with our top college football predictions for Week 5 as we attack the odds from our best college football betting sites.

Saturday's top games include No. 3 Texas hosting No. 24 Kansas, No. 17 Duke hosting No. 11 Notre Dame, and 12th-ranked Alabama visiting unranked Mississippi State.

Read on as we break down the best college football odds for our Week 5 predictions on all of the marquee games.

College football picks and predictions for Week 5

College football predictions for Saturday

LSU vs. Ole Miss pick: LSU Over 34 (-110 via bet365) ⭐⭐⭐

LSU-Ole Miss pick made by Phil Wood

Notre Dame vs. Duke pick: Notre Dame -5.5 (-110 via DraftKings) ⭐⭐⭐

Notre Dame-Duke pick made by Brenden Schaeffer

Alabama vs. Mississippi State pick: Mississippi State +14.5 (-110 via DraftKings) ⭐⭐⭐

Alabama-Mississippi State pick made by Brenden Schaeffer

College football expert picks for Week 5

Kentucky bettors: Sports betting is here!

Kentucky sports betting launched on Sept. 28 - so sign up with the best Kentucky sportsbook promos now! And check out our list of the best Kentucky sports betting apps!

21+ and present in KY. Gambling Problem? Call 1-800-GAMBLER

College football odds pages

CFP National Championship OddsSEC OddsBig 12 Odds
Heisman Trophy OddsBig Ten OddsPac-12 Odds
College Football Playoff OddsMountain West OddsACC Odds

Here are our best college football betting sites:

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Related pages

Written By:
Esten McLaren
Esten is the Senior Publishing Editor for SportsbookReview.com. He previously spent time as the Managing Editor of SportsbookWire.com, and he has done freelance work in sports betting for TheLines, PlayPicks, and BettingPros. He's well versed in the NFL, NHL, MLB, and NBA, but his true passion is with the PGA Tour. Esten's always happy to chase a long shot and will never shy away from a futures bet, but he'll never stop backing Rory McIlroy in majors. He's also a recovering Ottawa Senators and Atlanta Falcons fan. Always bet against the Toronto Maple Leafs at plus money.