College Football Expert Picks Today: Predictions & Best Bets for Every Game Tonight

We've gathered all of our expert picks for tonight, including two games with a ranked opponent on the road against a conference foe.
College Football Expert Picks Today: Predictions, Odds & Best Bets Tonight
Pictured: Houston Cougars running back Dean Connors (44) dives for the end zone pylon. Photo by Troy Taormina / Imagn Images.

We're in store for one of the best college football schedules of the season this weekend, and we've gathered our college football expert picks for the three-game appetizer tonight as part of our college football predictions for Week 5.

Our college football experts have broken down Florida State vs. Virginia, TCU vs. Arizona State, and Houston vs. Oregon State with their best college football picks against the spread, best Over/Under picks, and top player prop bets.


🏈 Florida State vs. Virginia predictions & odds

College Football Expert Picks Today: Predictions, Odds & Best Bets Tonight
Pictured: Florida State Seminoles quarterback Thomas Castellanos (1) celebrates with offensive lineman Gunnar Hansen (55). Photo by Melina Myers / Imagn Images.

💰️ Best bets for Florida State vs. Virginia

  • Game pick: Virginia +7 (-110 via DraftKings) ⭐⭐⭐
  • Over/Under pick: Over 60 (-110 via Caesars) ⭐⭐⭐⭐
  • Player prop bet: Chandler Morris Over 1.5 passing TDs (+110 via FanDuel) ⭐⭐⭐⭐
  • Touchdown scorer: Samuel Singleton Jr. anytime TD (+185 via DraftKings) ⭐⭐⭐

✅ Best Florida State vs. Virginia pick

Here's a look at why our college football expert Rob Paul is backing the Over between two ACC teams that have lit up the scoreboard so far this season:

"This should be a fun one under the Friday night lights, with Virginia being for Over lovers so far this season. While the Cavs have struggled throughout Tony Elliott's tenure as head coach, a top 30 transfer portal class that was ranked No. 2 in transfer production coming into the season has helped turn this team around, particularly on offense."

👀 More Florida State vs. Virginia picks

Rob Paul breaks down his best ATS prediction, O/U pick, and favorite player prop bet in his Florida State vs. Virginia prediction.


🔥 Best Florida State vs. Virginia player prop bet

Here's a look at why our college football expert Matt Jacob is betting on Virginia QB Chandler Morris to throw multiple touchdown passes tonight:

"Over the past three seasons, Chandler Morris has started 23 games for TCU, North Texas, and Virginia. The sixth-year senior has thrown multiple touchdowns in 16 of those contests, including four in last week’s 48-20 beatdown of Stanford. That’s one more aerial TD than the Cardinal allowed in their first three games combined."

👀 More Florida State vs. Virginia player props

Matt Jacob is fading two other skill-position stars in his Florida State vs. Virginia player prop picks.


💪 Best Florida State vs. Virginia anytime touchdown scorer prediction

Here's a look at why our college football expert Isaiah Sirois is betting on Florida State rusher Samuel Singleton Jr. to reach pay dirt tonight at Virginia:

"Running back Samuel Singleton Jr. isn’t the starter, but he has been exceptionally efficient on limited volume. His 14 carries have gone for 168 yards (12 per attempt) and three scores. He may not be the lead back like Gavin Sawchuk, who has 25 carries for 160 yards (6.4) and five scores, but I wouldn’t be surprised to see him break off a big gain for a touchdown."

👀 More Florida State vs. Virginia touchdown bets

Isaiah Sirois is targeting a Virginia receiver and Florida State's dual-threat quarterback in his Florida State vs. Virginia anytime touchdown scorer predictions.


📊 Live Florida State vs. Virginia odds

📺️ How to watch Florida State vs. Virginia

When: Friday, Sept. 26 @ 7 p.m. ET

Where: Scott Stadium (Charlottesville, Va.)

TV: ESPN


🏈 TCU vs. Arizona State predictions & odds

College Football Expert Picks Today: Predictions, Odds & Best Bets Tonight
Pictured: TCU Horned Frogs wide receiver Eric McAlister (1) and wide receiver Jordan Dwyer (7) celebrate after McAlister scores a touchdown. Photo by Jerome Miron / Imagn Images.

💰️ Best bets for TCU vs. Arizona State

  • Game pick: TCU +3 (-110 via Caesars) ⭐⭐⭐⭐
  • Over/Under pick: Over 54.5 (-110 via bet365) ⭐⭐
  • Player prop bet: Sam Leavitt Over 1.5 passing TDs (-125 via Caesars) ⭐⭐⭐⭐
  • Touchdown scorer: Jordan Dwyer to score anytime TD (+130 via bet365) ⭐⭐⭐⭐

✅ Best TCU vs. Arizona State pick

Here's a look at why Sirois is betting on the Horned Frogs to cover as road underdogs tonight in a tough Big 12 matchup in the desert:

"Back TCU to cover and win. The Frogs are the better team, but with them getting a field goal, the market believes this is a pick’em on a neutral site. I disagree, and so do the analytics. The Fremeau Efficiency Index (FEI) makes this a pick’em at Arizona State’s home field – and that model gives the Sun Devils credit for much of last year’s run, which relied on departed star running back Cam Skattebo."

👀 More TCU vs. Arizona State picks

Isaiah Sirois breaks down his best ATS prediction, O/U pick, and favorite player prop bet in his TCU vs. Arizona State prediction.


🔥 Best TCU vs. Arizona State player prop bet

Here's a look at why Jacob is betting on Arizona State QB Sam Leavitt to throw multiple touchdown passes tonight:

"One reason I love this TCU vs. Arizona State prop bet: Abilene Christian's Stone Earle threw two TDs against the Horned Frogs two weeks ago, and SMU's Kevin Jennings tossed three last week. Another reason: Since Week 5 of last season, Arizona State QB Sam Leavitt has had at least two passing touchdowns in eight of 12 games, and he threw more than two six times."

👀 More TCU vs. Arizona State player props

Matt Jacob is backing both QBs and one of their star wideouts with his TCU vs. Arizona State player prop picks.


💪 Best TCU vs. Arizona State anytime touchdown scorer prediction

Here's a look at why our college football expert Phil Wood is betting on TCU receiver Jordan Dwyer to reach pay dirt tonight at Arizona State:

"Though he’s tied for second on the team in touchdown receptions, (Dwyer) has scored in two of three games, while his teammate Eric McAlister scored all his touchdowns last week. Dwyer leads the team with 17 receptions, and as long as Josh Hoover doesn’t find a crazy mismatch like he did last week with McAlister, Dwyer should be the team’s No. 1 receiver."

👀 More TCU vs. Arizona State touchdown bets

Phil Wood is eyeing three receivers to score tonight with his TCU vs. Arizona State anytime touchdown scorer predictions.


📊 Live TCU vs. Arizona State odds

📺️ How to watch TCU vs. Arizona State

When: Friday, Sept. 26 @ 9 p.m. ET

Where: Mountain America Stadium (Tempe, Ariz.)

TV: FOX


🏈 Houston vs. Oregon State predictions & odds

College Football Expert Picks Today: Predictions, Odds & Best Bets Tonight
Pictured: Oregon State Beavers quarterback Maalik Murphy (6) throws a pass against the California Golden Bears. Photo by Craig Strobeck / Imagn Images.

💰️ Best bets for Houston vs. Oregon State

  • Game pick: Oregon State +13.5 (-110 via DraftKings) ⭐⭐⭐⭐
  • Over/Under pick: Under 47.5 (-110 via BetMGM) ⭐⭐⭐
  • Player prop bet: Maalik Murphy Over 227.5 passing yards (-115 via BetMGM) ⭐⭐⭐⭐
  • Touchdown scorer: Dean Connors 2+ touchdowns (+235 via DraftKings) ⭐⭐⭐⭐

✅ Best Houston vs. Oregon State pick

Here's a look at why our college football expert Mike Spector is betting on the Beavers to keep it close tonigth in Corvallis against the undefeated Cougars:

"Oregon State should be in for positive regression from a turnover standpoint after starting the season with a minus-four turnover margin. The Beavers committed two turnovers apiece in each of their first two home games, but also outgained those opponents (California and Fresno State) by a combined 167 total yards and had more first downs in each contest."

👀 More Houston vs. Oregon State picks

Mike Spector breaks down his best ATS prediction, O/U pick, and favorite player prop bet in his Houston vs. Oregon State prediction.


🔥 Best Houston vs. Oregon State player prop bet

Here's a look at why our college football expert Brendan Schaeffer is betting on Oregon State QB Maalik Murphy to throw for at least 228 yards tonight:

"Statistically, it’s another top-five pass defense in the nation on tap for Friday as Murphy faces a Houston unit that has allowed just 127.5 passing yards per game. But Houston’s only opponent of note was Colorado, and the Buffaloes started a backup who still managed 204 yards against the Cougars' secondary."

👀 More Houston vs. Oregon State player props

Brenden Schaeffer is also betting on a big night for Houston's offense with his Houston vs. Oregon State player prop picks


💪 Best Houston vs. Oregon State anytime touchdown scorer prediction

Here's a look at why Wood is betting on Houston risher Dean Connors to score multiple touchdowns tonight against Oregon State:

"While Connors will need to compete with quarterback Conner Weigman for carries, he's logged 16 more attempts than the signal-caller this year, even though they've both tallied the same number of touchdowns. However, in a game sure to feature plenty of scoring, I’ll take the rusher averaging 5.4 yards per carry against a defense allowing 4.9 yards per attempt, as he can score from anywhere on the field."

👀 More Houston vs. Oregon State touchdown bets

Phil Wood is also targeting a tight end and quarterback to reach the end zone tonight with his Houston vs. Oregon State anytime touchdown scorer predictions.


📊 Live Houston vs. Oregon State odds

📺️ How to watch Houston vs. Oregon State

When: Friday, Sept. 26 @ 10:30 p.m. ET

Where: Reser Stadium (Corvallis, Ore.)

TV: ESPN


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