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Jack Plummer of the Louisville Cardinals is featured in our favorite Kentucky vs. Louisville prediction for Week 13.
Jack Plummer of the Louisville Cardinals rolls out to pass against the Georgia Tech Yellow Jackets at Mercedes-Benz Stadium in Atlanta, Georgia. Photo by Todd Kirkland/Getty Images via AFP.

Our Murray State vs. Louisville prediction factors in the Cardinals coming off a thrilling win to start the season as they prepare for the Racers. Check out our top college football picks based on the best college football odds.

In Week 1 of the season, the Louisville Cardinals traveled to Atlanta and triumphed over the Georgia Tech Yellow Jackets in a thrilling game, starting the season with a 1-0 record. Quarterback Jack Plummer of the Cardinals passed for 247 yards and threw three touchdowns while running back Jawhar Jordan rushed for 96 yards, with a remarkable 74-yard touchdown run in the fourth quarter.  

The Murray State Racers experienced no such drama in their Week 1 win over the Presbyterian Blue Hose. They outgained the Blue Hose 484 yards to 196 while possessing the ball for almost 37 minutes. Eric Phoenix and DJ Williams each saw meaningful time under center, while five different rushers cracked 25 yards.

Here is our best Murray State vs. Louisville prediction (odds via our best college football betting sites; pick confidence based on a 1-to-5-star scale).

Murray State vs. Louisville prediction: Week 2

Under 55.5 (-110 via BetMGM) ⭐⭐

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Following their impressive Week 1 victory, the Cardinals have a relatively easy matchup against the Indiana Hoosiers in Week 3, almost akin to a bye week. Despite the potential for some post-win fatigue, the Cardinals are expected to dominate this game quickly.

The hardest part about picking a matchup like this is knowing how long starters stay on the field. It’s unlikely Plummer plays much in the second half, and after Jordan ran the ball just seven times in Week 1, it’s difficult to imagine the Cardinals overusing him this week with so many meaningful contests on the horizon.

With such a predicament, back the Under. The Cardinals will be a little lackadaisical as they take the Racers for granted, but Murray State isn't good enough to take advantage of this lapse and put points on the board early.

After a low-scoring first half, the Cardinals should start to pour it on in the second session. But they won’t score so many points that they push this total Over on their own. It’s hard to know whether or not they'll score enough to cover the incredibly large spread of 41 for our college football Week 2 predictions.

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Murray State vs. Louisville best odds

BetMGM (-110)

DraftKingsFanDuelBetMGMCaesarsbet365
Under 54.5Under 54.5Under 55.5N/AN/A
-110-110-110N/AN/A

BetMGM followed DraftKings and FanDuel in posting odds for Murray State vs. Louisville but provided the best line for Under bettors once it did. Bettors can get the higher line of 55.5 with equal -110 odds on either side.

Since this isn't a must-play by any means, you could wait to see what totals the other best sports betting apps release, then play the highest number. Additionally, if any of these best sports betting sites release first-quarter totals, it's definitely worth taking the Under if it's listed at 13.5 or higher.

Murray State vs. Louisville odds

Murray State vs. Louisville odds analysis

The lines for this game were released just hours ago, so there hasn't been much movement. With a number this large, expect to see bettors back the underdog even if there's no reason to believe in them. The Cardinals haven't been a great in recent years, so there's  really no reason to trust them as 41-point favorites. This number should drop to 39 or 39.5 before kickoff.

As for the total, it’s really hard to say what will happen. The number is at 54.5 right now, so oddsmakers believe the Racers can score at least a few points in this one. It’s hard to trust FCS teams against Power 5 opponents, so maybe bettors will support the Under. But then again, the Cardinals' offense should have a field day. Don’t expect too much movement with the total.

Murray State vs. Louisville game info

  • When: Thursday, Sept. 7, 7:30 p.m. ET
  • Where: Cardinal Stadium, Louisville, KY
  • How to watch: ACC Network
  • Weather: 65 degrees, 0% chance of precipitation, 6-mph winds

Murray State-Louisville prediction made 9/6/23 at 4:57 p.m. ET.

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