Heisman Trophy Odds 2025: Biggest Week 5 Takeaways and Betting Movement

Last Updated: September 27, 2025 11:25 PM EDT • 3 minute read X Social Google News Link

Following a Week 5 that was arguably the best of the college football season, there's a new Heisman Trophy odds favorite after Indiana's Fernando Mendoza didn't have his best showing against Iowa.
Mendoza had the top spot on the board heading into Week 5 after it was announced earlier in the week that the previous favorite, Oklahoma's John Mateer, would miss several weeks due to a thumb injury. But Mendoza's hold didn't last long after Oregon's Dante Moore led the Ducks to a double overtime win against Penn State on the road in Week 5.
So with Moore as the new Heisman Trophy odds favorite, is he the best player to bet with your college football picks following Week 5?
🔀 Week 5 Heisman Trophy odds movement & key takeaways
- After it was announced that Oklahoma's John Mateer needed thumb surgery, causing his odds to lengthen from +900 to +10000, Indiana's Fernando Mendoza jumped to the top of the Heisman Trophy odds; however, the Hoosiers' QBs' odds lengthened from +750 to +1600 after his lackluster game against Iowa
- Oregon's Dante Moore trailed only Mendoza heading into Week 5 against Penn State and after his performance, his odds shortened from +1000 to +900 to make him the new favorite
- Despite being on a bye this week, Miami's Carson Beck remains a top Heisman contender and saw his odds move from +1200 to +1100, trailing only Moore
- A few weeks ago, LSU's Garrett Nussmeier was the Heisman favorite with odds as short as +650, but after a Week 5 loss to Ole Miss, his odds are now +3500
- Both Ohio State's Jeremiah Smith (+1200) and Julian Sayin (+1900) remain legitimate contenders as the stars of the No. 1 team in the country
- Although Alabama's Ty Simpson upset Georgia on the road, his odds only shortened from +2500 to +2200
📊 Live Heisman Trophy odds 2025
The latest Heisman Trophy odds; see the latest college football odds in real time.
❓ Heisman Trophy FAQs
Who is the Heisman Trophy favorite?
Oregon quarterback Dante Moore is the new Heisman Trophy odds favorite with his odds shortening from +1000 to +900 following Week 5. His odds (+900) imply a 16.67% probability he will win the award.
What are Arch Manning's Heisman Trophy odds?
After opening with Heisman odds of +950 and seeing them shorten to no longer than +700, Arch Manning's Heisman Trophy odds lengthened to +1800 following Week 1. They then shortened to +1600, following Week 2, but plummeted to between +3000 and +4000 after Week 3. Manning's Heisman Trophy odds are +4000 following Week 5, implying a 2.44% probability he'll win the award.
When will the Heisman Trophy be decided?
The 2025 Heisman Trophy ceremony will be Saturday, Dec. 13, at 8 p.m. ET on ESPN.
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Rob Paul X social