College Football Playoff Predictions: CFP Picks, Odds & Best Bets for Semifinals

We're breaking down our College Football Playoff predictions for both the final CFP semifinal: Oregon vs. Indiana.
Oregon Ducks linebacker Jerry Mixon sacks Indiana Hoosiers quarterback Fernando Mendoza as we make our best CFP predictions.
Pictured: Oregon Ducks linebacker Jerry Mixon sacks Indiana Hoosiers quarterback Fernando Mendoza as we make our best CFP predictions. Photo by Troy Wayrynen-Imagn Images
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Just three teams remain in the hunt for the college football national championship, and our College Football Playoff predictions feature our best college bowl game predictions for the CFP semifinals ahead of Oregon vs. Indiana on Friday. Who will face Miami in the national championship game? Our best bets include our top ATS picks, player props, and touchdown scorer bets break down the season's penultimate game.


🏈 Oregon vs. Indiana predictions & odds (Jan. 9 @ 7:30 p.m. ET)

The Big Ten takes center stage in the second College Football Playoff semifinal matchup with Oregon and Indiana facing off for the second time this season. The Hoosiers got the best of the Ducks when they met in Autzen Stadium back on Oct. 11 en route to their first undefeated season in school history - that also marks the only loss all season for Dan Lanning and Co. ahead of their second appearance in the CFP semifinals. This is also a rematch between Fernando Mendoza and Dante Moore, the likely top two picks by the latest NFL draft odds, while these defenses are among the most loaded in the sport.

Live Oregon vs. Indiana odds

Oregon vs. Indiana prediction

🔴 Indiana -3.5

The last time these two programs played, Indiana announced itself as the best team in the country with a 10-point road win against Oregon. This time around, the Hoosiers are the clear top team in the country, ranked No. 3 on offense and No. 2 on defense by SP+.

- via Rob Paul's Oregon vs. Indiana prediction

More Oregon vs. Indiana picks


📅 College Football Playoff schedule & odds: CFP semifinals

See the latest college football odds and our college football picks for every bowl game. All games will be televised on ESPN.

Kickoff (ET) Matchup (seed) Favorite
Thursday, Jan. 8 @ 7:30 PM Miami (10) vs. Ole Miss (6) Miami -3.5
Friday, Jan. 9 @ 7:30 PM Oregon (5) vs. Indiana (1) Indiana -3.5

💰 More college football bowl predictions & expert picks


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