Buffalo Bills at Cincinnati Bengals (-5)
Why Bills cover: They're 6-1 ATS in their last seven meetings. Fred Jackson racked up 170 total yards last week and will get to test a Cincinnati defense that has allowed over 100 yards rushing seven times this season.
Why Bengals cover: Buffalo’s defense has forced an NFL-low eight turnovers and ranks dead last in the league against the run.
Total (44): Over is 5-2 in the last seven meetings.
Detroit Lions at Dallas Cowboys (-6.5)
Why Lions cover: Five of their seven losses this season have been decided by five points or less.
Why Cowboys cover: They responded well to new coach Jason Garrett last week and will host a Detroit squad that hasn't won on the road since Week 8 of the 2007 season.
Total (47): Over is 4-1 in the last five meetings.
Arizona Cardinals at Kansas City Chiefs (-9)
Why Cardinals cover: Teams have been finding ways to slow down the Chiefs’ league-leading rushing attack in recent weeks which puts more pressure on quarterback Matt Cassel.
Why Chiefs cover: The home team is 4-0 ATS in their last four meetings. Due to their inconsistent quarterback play, Arizona ranks second last in the NFL in total yards per game, offensive touchdowns and passer rating.
Total (44): Over is 7-1 in the Cardinals' last eight games and 4-1 in the Chiefs' last five games.
Houston Texans at New York Jets (-7)
Why Texans cover: They could follow Cleveland's formula from last week and keep the game within reach by pounding the ball on the ground with Arian Foster, who leads the league in rushing.
Why Jets cover: The Texans are 0-4 ATS in their last four meetings. Matt Schaub was hospitalized this week to deal with a bursa sac problem in his knee and will not be at 100 percent.
Total (45.5): Under is 4-0 in the last four meetings.
Cleveland Browns at Jacksonville Jaguars (-1)
Why Browns cover: They're 4-1 ATS in their last five meetings in Jacksonville. The road team is 5-1 ATS in their last six meetings.
Why Jaguars cover: David Garrard and Maurice Jones-Drew are playing their best football of the season and the Browns will be without second-leading tackler Scott Fujita and possibly cornerback Sheldon Brown, who is questionable.
Total (43): Over is 4-0 in the Browns' last four games and 5-1 in the Jaguars' last six games.
Oakland Raiders at Pittsburgh Steelers (-9)
Why Raiders cover: They're 4-1 ATS in their last five meetings. The underdog is 6-1 ATS in their last seven meetings. They could get both Nnamdi Asomugha and Zach Miller back from their injuries.
Why Steelers cover: They allow a league-low 63.2 yards per game on the ground. If Oakland can't get its rushing game going it will be up to an inconsistent Jason Campbell to move the ball through the air.
Total (41.5): Over is 5-2 in the Raiders' last seven road games and 4-1 in the Steelers' last five games overall.
Baltimore Ravens at Carolina Panthers (+10)
Why Ravens cover: The Panthers average an NFL-worst 11.6 points per game and will start rookie Tony Pike at quarterback with Jimmy Clausen and Matt Moore out.
Why Panthers cover: The Ravens' defense has been uncharacteristically porous recently, allowing 23.3 points per game over their last four contests.
Total (37): Under is 5-1 in the Ravens' last six road games and 12-4 in the Panthers' last 16 games overall.
Green Bay Packers at Minnesota Vikings (+3)
Why Packers cover: They're 5-2 ATS in their last seven meetings and 5-2 ATS in their last seven meetings in Minnesota. The road team is 12-5 ATS in their last 17 meetings.
Why Vikings cover: The Packers are banged up on defense with defensive end Ryan Pickett and sack machine Clay Matthews questionable for Sunday.
Total (44): Over is 15-5-1 in the last 21 meetings and 3-0-1 in the last four meetings in Minnesota.
Washington Redskins at Tennessee Titans (-7)
Why Redskins cover: Keiland Williams has averaged 5.18 yards per carry and has scored four touchdowns in two games since replacing injured Ryan Torain at running back.
Why Titans cover: They will get Vince Young back from his ankle injury to face a Washington defense that continues to get torched, allowing an NFL-high 415.3 yards per game.
Total (44): Over is 4-0 in the last four meetings.
Atlanta Falcons at St. Louis Rams (+3)
Why Falcons cover: Their no-huddle offense is keeping opposing defenses on their heels and allowing Matt Ryan and Roddy White to make big plays downfield.
Why Rams cover: The Falcons are 3-8 ATS in their last 11 meetings and 1-4 ATS in their last five meetings in St. Louis. The home team is 5-1 ATS in their last six meetings.
Total (43): Over is 4-0 in the last four meetings.
Tampa Bay Buccaneers at San Francisco 49ers (-3)
Why Buccaneers cover: They are averaging 140 yards per game on the ground since anointing LeGarrette Blount the lead rusher. Joe Nedney's absence will be a huge blow to the 49ers' special teams.
Why 49ers cover: The home team is 6-0 ATS in their last six meetings. Troy Smith has thrown for 552 yards and has not committed a turnover in two games since becoming the 49ers’ starting quarterback.
Total (41.5): Under is 5-1 in the last six meetings.
Seattle Seahawks at New Orleans Saints (-12)
Why Seahawks cover: They could get rookie left tackle Russell Okung back from his ankle injury to protect Matt Hasselbeck and open up hole for the running game.
Why Saints cover: Reggie Bush could finally return from his broken fibula to spark the ground game. Their defense is holding opponents to just 16.8 points per game.
Total (44.5): Under is 4-1 in the last five meetings.
Indianapolis Colts at New England Patriots (-3)
Why Colts cover: They're 4-1-1 ATS in their last six meetings. The underdog is 11-3-2 ATS in their last 16 meetings. The past five meetings have been decided by seven points or less.
Why Patriots cover: The Colts are only averaging 81.6 rushing yards per game since Joseph Addai went down and with all the injured receivers, Indianapolis could have a hard time keeping up with New England's offense.
Total (50.5): Over is 7-1 in the Colts' last eight road games and 4-1 in the Patriots' last five home games.
New York Giants at Philadelphia Eagles (-3)
Why Giants cover: They're 4-1 ATS in their last five meetings in Philadelphia. The road team is 5-1 ATS in their last six meetings. The underdog is 10-1 ATS in their last 11 meetings.
Why Eagles cover: Michael Vick is coming off arguably the best game of his career and has the ability to avoid New York's feared pass rush which is their biggest asset.
Total (48.5): Over is 8-3-1 in the last 12 meetings in Philadelphia.
Denver Broncos at San Diego Chargers (-10)
Why Broncos cover: Antonio Gates is dealing with a foot injury and is questionable to suit up on Monday. Running back Ryan Mathews is also in danger of missing this game with an injured ankle.
Why Chargers cover: The favorite is 5-1-1 ATS in their last seven meetings. The Broncos are 1-6-1 ATS in their last eight meetings. Receivers Legedu Naanee and Malcom Floyd are both expected to return from their hamstring injuries.
Total (50.5): Over is 6-2 in the last eight meetings and the top two passers in the league will face off
Why Bills cover: They're 6-1 ATS in their last seven meetings. Fred Jackson racked up 170 total yards last week and will get to test a Cincinnati defense that has allowed over 100 yards rushing seven times this season.
Why Bengals cover: Buffalo’s defense has forced an NFL-low eight turnovers and ranks dead last in the league against the run.
Total (44): Over is 5-2 in the last seven meetings.
Detroit Lions at Dallas Cowboys (-6.5)
Why Lions cover: Five of their seven losses this season have been decided by five points or less.
Why Cowboys cover: They responded well to new coach Jason Garrett last week and will host a Detroit squad that hasn't won on the road since Week 8 of the 2007 season.
Total (47): Over is 4-1 in the last five meetings.
Arizona Cardinals at Kansas City Chiefs (-9)
Why Cardinals cover: Teams have been finding ways to slow down the Chiefs’ league-leading rushing attack in recent weeks which puts more pressure on quarterback Matt Cassel.
Why Chiefs cover: The home team is 4-0 ATS in their last four meetings. Due to their inconsistent quarterback play, Arizona ranks second last in the NFL in total yards per game, offensive touchdowns and passer rating.
Total (44): Over is 7-1 in the Cardinals' last eight games and 4-1 in the Chiefs' last five games.
Houston Texans at New York Jets (-7)
Why Texans cover: They could follow Cleveland's formula from last week and keep the game within reach by pounding the ball on the ground with Arian Foster, who leads the league in rushing.
Why Jets cover: The Texans are 0-4 ATS in their last four meetings. Matt Schaub was hospitalized this week to deal with a bursa sac problem in his knee and will not be at 100 percent.
Total (45.5): Under is 4-0 in the last four meetings.
Cleveland Browns at Jacksonville Jaguars (-1)
Why Browns cover: They're 4-1 ATS in their last five meetings in Jacksonville. The road team is 5-1 ATS in their last six meetings.
Why Jaguars cover: David Garrard and Maurice Jones-Drew are playing their best football of the season and the Browns will be without second-leading tackler Scott Fujita and possibly cornerback Sheldon Brown, who is questionable.
Total (43): Over is 4-0 in the Browns' last four games and 5-1 in the Jaguars' last six games.
Oakland Raiders at Pittsburgh Steelers (-9)
Why Raiders cover: They're 4-1 ATS in their last five meetings. The underdog is 6-1 ATS in their last seven meetings. They could get both Nnamdi Asomugha and Zach Miller back from their injuries.
Why Steelers cover: They allow a league-low 63.2 yards per game on the ground. If Oakland can't get its rushing game going it will be up to an inconsistent Jason Campbell to move the ball through the air.
Total (41.5): Over is 5-2 in the Raiders' last seven road games and 4-1 in the Steelers' last five games overall.
Baltimore Ravens at Carolina Panthers (+10)
Why Ravens cover: The Panthers average an NFL-worst 11.6 points per game and will start rookie Tony Pike at quarterback with Jimmy Clausen and Matt Moore out.
Why Panthers cover: The Ravens' defense has been uncharacteristically porous recently, allowing 23.3 points per game over their last four contests.
Total (37): Under is 5-1 in the Ravens' last six road games and 12-4 in the Panthers' last 16 games overall.
Green Bay Packers at Minnesota Vikings (+3)
Why Packers cover: They're 5-2 ATS in their last seven meetings and 5-2 ATS in their last seven meetings in Minnesota. The road team is 12-5 ATS in their last 17 meetings.
Why Vikings cover: The Packers are banged up on defense with defensive end Ryan Pickett and sack machine Clay Matthews questionable for Sunday.
Total (44): Over is 15-5-1 in the last 21 meetings and 3-0-1 in the last four meetings in Minnesota.
Washington Redskins at Tennessee Titans (-7)
Why Redskins cover: Keiland Williams has averaged 5.18 yards per carry and has scored four touchdowns in two games since replacing injured Ryan Torain at running back.
Why Titans cover: They will get Vince Young back from his ankle injury to face a Washington defense that continues to get torched, allowing an NFL-high 415.3 yards per game.
Total (44): Over is 4-0 in the last four meetings.
Atlanta Falcons at St. Louis Rams (+3)
Why Falcons cover: Their no-huddle offense is keeping opposing defenses on their heels and allowing Matt Ryan and Roddy White to make big plays downfield.
Why Rams cover: The Falcons are 3-8 ATS in their last 11 meetings and 1-4 ATS in their last five meetings in St. Louis. The home team is 5-1 ATS in their last six meetings.
Total (43): Over is 4-0 in the last four meetings.
Tampa Bay Buccaneers at San Francisco 49ers (-3)
Why Buccaneers cover: They are averaging 140 yards per game on the ground since anointing LeGarrette Blount the lead rusher. Joe Nedney's absence will be a huge blow to the 49ers' special teams.
Why 49ers cover: The home team is 6-0 ATS in their last six meetings. Troy Smith has thrown for 552 yards and has not committed a turnover in two games since becoming the 49ers’ starting quarterback.
Total (41.5): Under is 5-1 in the last six meetings.
Seattle Seahawks at New Orleans Saints (-12)
Why Seahawks cover: They could get rookie left tackle Russell Okung back from his ankle injury to protect Matt Hasselbeck and open up hole for the running game.
Why Saints cover: Reggie Bush could finally return from his broken fibula to spark the ground game. Their defense is holding opponents to just 16.8 points per game.
Total (44.5): Under is 4-1 in the last five meetings.
Indianapolis Colts at New England Patriots (-3)
Why Colts cover: They're 4-1-1 ATS in their last six meetings. The underdog is 11-3-2 ATS in their last 16 meetings. The past five meetings have been decided by seven points or less.
Why Patriots cover: The Colts are only averaging 81.6 rushing yards per game since Joseph Addai went down and with all the injured receivers, Indianapolis could have a hard time keeping up with New England's offense.
Total (50.5): Over is 7-1 in the Colts' last eight road games and 4-1 in the Patriots' last five home games.
New York Giants at Philadelphia Eagles (-3)
Why Giants cover: They're 4-1 ATS in their last five meetings in Philadelphia. The road team is 5-1 ATS in their last six meetings. The underdog is 10-1 ATS in their last 11 meetings.
Why Eagles cover: Michael Vick is coming off arguably the best game of his career and has the ability to avoid New York's feared pass rush which is their biggest asset.
Total (48.5): Over is 8-3-1 in the last 12 meetings in Philadelphia.
Denver Broncos at San Diego Chargers (-10)
Why Broncos cover: Antonio Gates is dealing with a foot injury and is questionable to suit up on Monday. Running back Ryan Mathews is also in danger of missing this game with an injured ankle.
Why Chargers cover: The favorite is 5-1-1 ATS in their last seven meetings. The Broncos are 1-6-1 ATS in their last eight meetings. Receivers Legedu Naanee and Malcom Floyd are both expected to return from their hamstring injuries.
Total (50.5): Over is 6-2 in the last eight meetings and the top two passers in the league will face off