NFL Odds Week 1: Lines, Spreads & Totals for Every Game

📊 NFL odds Week 1 2025

The NFL odds for Week 1 are via bet365, as of Thursday, Sept. 4

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It's finally time. We have our NFL picks loaded up, the opening kickoff of the season is hours away.

Like the first week of any NFL season, we're treated to extra primetime games and so many exciting storylines.

• The defending Super Bowl odds champion Eagles (-8) host the Cowboys on Thursday, kicking season off at 8:20 p.m. ET (NBC), but it's not an official Thursday Night Football tilt
• A bonus Friday nighter from Brazil sees the Chargers (+3) catching points against the "visiting" Chiefs (8 p.m. ET, YouTube)
• No. 1 overall draft pick Cam Ward is the only rookie QB to start the season as his Titans (+8.5) visit the Broncos on Sunday (4:05 p.m. ET, FOX)
• The Sunday Night Football odds have the Bills (+1) squaring off with the Ravens in Buffalo at 8:20 p.m. ET (NBC) in a clash of NFL MVP odds contenders
• Longtime Rivals, the Vikings (-1.5) and Bears clash on Monday Night Football (8:15 p.m. ET, ABC/ESPN) to cap the week

Liam Fox's NFL weather report for Week 1 assesses the game-time conditions for the NFL's 12 games in open-air stadiums this week, and how those may influence the Week 1 odds and betting lines. Gary Pearson's NFL live betting guide has you covered for in-game wagers on this week's four prime-time games.

🏈 Cowboys vs. Eagles odds: Thursday

• Kickoff: 8:20 p.m. ET from Lincoln Financial Field (Philadelphia)
• How to watch: NBC/Peacock
• Cowboys vs. Eagles prediction: Eagles -8 (-110) via Gary Pearson

🏈 Chiefs vs. Chargers odds: Friday 

• Kickoff: 8 p.m. ET from Corinthians Arena (Sao Paulo, Brazil)
• How to watch: YouTube
• Chiefs vs. Chargers prediction: Under 45.5 (-110) via Gary Pearson

🏈 Ravens vs. Bills odds: Sunday Night Football

• Kickoff: 8:20 p.m. ET from Highmark Stadium (Orchard Park, N.Y.)
• How to watch: NBC
• Ravens vs. Bills prediction: Over 50.5 (-105) via Mike Spector

🏈 Vikings vs. Bears odds: Monday Night Football

• Kickoff: 8:15 p.m. ET from Soldier Field (Chicago)
• How to watch: ABC/ESPN
• Vikings vs. Bears prediction: Under 44.5 (-110) via Gary Pearson

🔢 NFL Week 1 odds and lines

There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.

❓NFL odds FAQs

How do NFL spread odds work?

When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.

How do NFL moneyline odds work?

When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.

Where can I find the NFL betting odds?

Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.

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