Who’ll Win Virna Jandiroba vs. Mackenzie Dern Prediction & Odds Today: UFC 321 Abu Dhabi Best Bet

The best bet is Jandiroba by decision (+300), which plays to a scorecard-friendly outcome
Who’ll Win Virna Jandiroba vs. Mackenzie Dern Prediction & Odds
Pictured: Mackenzie Dern fights. Photo by Gary A. Vasquez-Imagn Images

The co-main event of UFC 321 today at Etihad Arena in Abu Dhabi, United Arab Emirates, features a high-stakes rematch for the vacant women’s strawweight title, as Mackenzie Dern faces Virna Jandiroba. Dern enters as the -163 betting favorite, but Jandiroba’s recent form, refined control game, and consistent round-banking make her a live underdog in my UFC picks.

My Jandiroba vs. Dern prediction today leans toward the Brazilian technician who wins with consistency, not chaos. The best bet is Jandiroba by decision (+300), which plays to a scorecard-friendly outcome that matches her recent blueprint of top control and safe advances.


🔮 Virna Jandiroba vs. Mackenzie Dern predictions: UFC 321

💰️ Jandiroba vs. Dern picks

  • Pick to win: Jandiroba (+137 via FanDuel) ⭐⭐⭐⭐
  • Best bet: Jandiroba by decision (+300 via bet365) ⭐⭐⭐

📊 Virna Jandiroba vs. Mackenzie Dern odds: UFC 321

Odds via BetMGM; subject to change.

Virna Jandiroba Mackenzie Dern
+137 Win outright -163
+1800 Win by KO/TKO/DQ +550
+450 Win by submission +275
+300 Win by decision +240
Over: -120 Over/Under 4.5 rounds Under: -106

🆚 Who will win Virna Jandiroba vs. Mackenzie Dern?

Jandiroba’s path to victory looks clearer in a five-round rematch. She attempts over twice as many takedowns as Dern (2.3 per 15 minutes vs 0.9) and lands them at higher efficiency. Her ability to dictate position, ride time, and control optics favors her across rounds, especially given Dern’s 52% striking defense and tendency to absorb nearly four significant strikes per minute. At +137, a $10 bet on Jandiroba returns $23.70 total.


💰 Virna Jandiroba vs. Mackenzie Dern best bet: UFC 321

Check our best UFC betting sites for the latest odds for this fight.

🔥 Jandiroba by Decision (+300)

This market aligns perfectly with Jandiroba’s current fighting identity. Jandiroba secured decision wins over Marina Rodriguez and Angela Hill by chaining takedowns, controlling from top, and avoiding submission scrambles that could reverse position. Those same traits apply here: patience, pressure, and position.

In their first meeting at UFC 256, Dern edged a 29-28 decision by keeping the fight upright. Since then, Jandiroba has tightened her clinch entries, refined her transitions, and leaned into a positional, risk-managed style. That approach wins rounds, not highlight reels. Her steady top control, short strikes, and superior cardio set up a 48-47 or 49-46 scorecard.

The metrics reinforce that Virna’s takedown attempts, higher control time, and a recent streak of smothering ranked opposition. Jandiroba’s positional game stacks minutes; Dern’s submission hunting often stalls when opponents resist chaos.


🔮 UFC 321 expert picks


🥊 Virna Jandiroba vs. Mackenzie Dern tale of the tape

Virna Jandiroba Mackenzie Dern
37 Age 32
5’3” Height 5’4”
115 lbs Weight 115 lbs
64” Reach 63”
22-3-0 Record 15-5-0
1 Wins by KO 0
14 Wins by submission 8
0 Head-to-head 1

📺 How to Virna Jandiroba vs. Mackenzie Dern

  • Date: Saturday, Oct. 25
  • Time: Main card starts at 2 p.m. ET
  • Location: Etihad Arena (Abu Dhabi, United Arab Emirates)
  • TV: ESPN+ Pay-Per-View

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