UFC 322 Predictions & Best Bets: Expert Picks for New York City

My UFC 322 predictions and best bets zero in on Islam Makhachev in his welterweight debut against rising star and current champ Jack Della Maddalena.

Makhachev enters as the -275 betting favorite at BetMGM, while Della Maddalena looks to pull the upset as a +215 betting underdog in a five-round main event that pits elite grappling versus world-class boxing. The event takes place on Saturday at Madison Square Garden in New York (10 p.m. ET, ESPN+), and the best bets below also feature Valentina Shevchenko (-128) vs. Zhang Weili (+110).

✅ UFC 322 predictions & expert picks

See all of our UFC picks for this weekend's fights.

📅 UFC 322: Makhachev vs. Della Maddalena fight card

• Islam Makhachev vs. Jack Della Maddalena, Welterweight
• Valentina Shevchenko vs. Zhang Weili, Flyweight Title
• Michael Morales vs. Sean Brady, Welterweight
• Leon Edwards vs. Carlos Prates, Welterweight

💰 UFC 322 best bets

Check our best UFC betting sites for the latest odds for this weekend's fights.

🏆 Islam Makhachev by submission vs. Jack Della Maddalena ⭐⭐⭐

Makhachev’s best path remains his relentless grappling. The test stiffens against Della Maddalena, who showed strong takedown defense against Belal Muhammad.

However, Islam’s chain wrestling and clinch control are another level entirely. Expect Della Maddalena to hang in early before the Dagestani star drags him into deep waters and finds a finish on the mat.

At +200 odds, Makhachev’s implied probability is 33.3%, meaning a $10 wager returns $20 profit.

🥊 Valentina Shevchenko ML vs. Zhang Weili ⭐⭐

This bout sets up as a chess match between elite technicians. Weili’s pace and strength will test Shevchenko, but “Bullet” boasts superior timing, defensive efficiency, and top-tier takedown accuracy (60%).

Expect long stretches of clinch work and measured exchanges, where Shevchenko’s composure and control edge out the volume. At −128, the implied probability is 56.1%, netting $7.81 profit on a $10 stake.

🥊 Sean Brady ML vs. Michael Morales ⭐⭐⭐

Sean Brady’s smothering wrestling and positional control should neutralize Michael Morales’ speed and length. Morales is the sharper striker, but Brady’s ability to find all types of angles for takedowns and wear on opponents with steady top pressure gives him multiple routes to win.

Expect a grinding three-round affair favoring Brady’s grappling consistency. bet365 offers the best price of the best sports betting sites. Those odds carry an implied probability of 58.0%, yielding $7.25 profit on a winning $10 wager.

🥊 Carlos Prates by decision vs. Leon Edwards ⭐⭐⭐⭐

Carlos Prates’ length, volume, and takedown defense make him a live underdog. His 78-inch reach, sharp body-kick game, and defensive awareness should allow him to dictate range and outwork Leon Edwards across three rounds.

The veteran’s patience may keep him safe, but Prates’ activity and Octagon control should win the judges’ cards. At +250, the implied probability is 28.6%, for a $25 profit on a $10 bet.

📺 How to watch UFC 322

• Date: Saturday, Nov. 15
• Time: 10 p.m. ET (main card)
• Location: Madison Square Garden (New York)
• TV: ESPN+ (U.S.), Sportsnet/UFC Fight Pass (Canada)