⚽ Barcelona vs. Atletico Madrid Prediction, Picks & Odds for Wednesday's Champions League Match

Barcelona look to take advantage of Atletico's depleted defense to secure first-leg advantage.
FC Barcelona's Robert Lewandowski celebrates a goal, and he's key as we look at our Atletico Madrid vs. Barcelona prediction.
Pictured: FC Barcelona's Robert Lewandowski celebrates a goal, and he's key as we look at our Atletico Madrid vs. Barcelona prediction. Photo by Acero/Alter Photos/Sipa USA.
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The Champions League quarterfinals feature an all-Spanish matchup at the Camp Nou, as my Barcelona vs. Atletico Madrid prediction breaks down Wednesday's clash.

Barcelona are the -185 favorites to beat an Atletico side getting moneyline odds of +425 to escape the Catalan capital with a victory. Our Champions League best bets also include a Barcelona player to target in the first leg.

The action begins at 3 p.m. ET Wednesday on Paramount+


⚽ Barcelona vs. Atletico Madrid predictions

See our experts' soccer picks based on the latest Champions League odds:

Predictions Best odds Bet size Confidence 
Barcelona ML -185 via DraftKings 2 units  1.1 units ⭐⭐⭐⭐
Over 2.5 -270 via DraftKings 1 unit -> 0.4 units ⭐⭐⭐⭐
Both teams score, 2nd half +150 via bet365 0.5 units -> 0.75 units ⭐⭐⭐
Robert Lewandowski anytime goal-scorer +100 via bet365 0.5 units -> 0.5 units ⭐⭐⭐

Total wagered: 4 units | Max profit: 2.75 units

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💰 Barcelona vs. Atletico Madrid best bet

Check out all of our soccer betting analysis and expert predictions this season.

Barcelona ML (-185)

Barcelona vs. Atletico Madrid is becoming the rivalry of the season in Spain. After facing off against each other last weekend, the La Liga rivals meet again Wednesday for the fifth time this season.

However, the stakes are higher Wednesday, as each team will try to boost its odds of reaching the Champions League semifinals.

After Barcelona emerged victorious a few days ago on the road against a 10-man Atletico, we're backing Hansi Flick's side to win again at home, where the team has only lost once in 20 combined games in the Champions League and La Liga

Score prediction: Barcelona 3, Atletico Madrid 1


🔥 Best Barcelona vs. Atletico Madrid prop bet

Both teams score in the second half (+150)

It won't be a surprise if this game gets off to a slow start, as the two teams try to feel each other out in the early stages of Wednesday's quarterfinal match.

But we're expecting things to open up in the second half. Barcelona will be eager to build a comfortable lead before the second leg in Madrid, while Atletico could take advantage of Barcelona's press and make them pay with a counter-attacking charge, with star forward Julian Alvarez leading the way.

Barcelona are especially effective in the second half of Champions League games, when 21 of their 30 goals have been scored. Meanwhile, Atletico are averaging one goal per game in the second of their last six Champions League matches.


🙌 Best Barcelona vs. Atletico Madrid goal-scorer prediction

Robert Lewandowski, Barcelona (+100) 

Robert Lewandowski could be set for increased opportunities with Raphinha still nursing an injury.

The Polish striker scored late in Saturday's game against Atletico to secure a 2-1 win for a Barcelona side that's currently first in La Liga, seven points ahead of Real Madrid.

Considering he only played 12 minutes during a cameo appearance off the bench over the weekend, the 37-year-old who has logged four goals in nine Champions League games this season should be fresh enough to start Wednesday's game. 

Although there are doubts about Lewandowski's abilities as he ages, he should get a boost in confidence when he goes up against Atletico's depleted defensive structure. It'll be missing major pillars such as top defender Jose Maria Gimenez and goalkeeper Jan Oblak.


🚀 Barcelona vs. Atletico Madrid same-game parlay

It's almost a repeat of what transpired over the weekend when Barcelona prevailed against Atletico Madrid.

However, we're leaning a bit harder into Barcelona playing better at home, where they've been dominant this season. Expect Atletico to be cautious in the first half before opening up after halftime and snatching a goal to make things interesting. But we're backing Robert Lewandowski to score and help put Barcelona one step closer to the Champions League semifinals.

💵 Barcelona vs. Atletico Madrid SGP picks

  • Barcelona ML (-18)
  • Both teams to score, 2nd half (+150)
  • Robert Lewandowski anytime goal-scorer (+100)

Best odds: +550 via bet365 (0.2 units -> 1.1 units)

⚖️ How I'm handicapping Barcelona vs. Atletico Madrid

Barcelona have evolved into a scoring machine under the guidance of Flick, averaging 2.67 goals per game in La Liga and three goals per outing in the Champions League.

While Barcelona are built to generate scoring opportunities, the team could find itself exposed at the back against an Atletico Madird outfit that excels on the counter.

However, considering that Atletico Madrid are missing a pair of key defending pieces, it's likely the outcome will lean toward the goal total hitting the Over. That's even more possible given that Barcelona are playing at home and possess one of the most talented attacking units in the world.

Barcelona vs. Atletico Madrid key stats

Barcelona Atletico Madrid
Goals for 30 31
Goals against 17 24
Possession 60.8% 50.25%
Attempts on target 71 73
Yellow cards 21 24

📊 Barcelona vs. Atletico Madrid odds

DraftKings features the best number for Barcelona on the three-way moneyline, which hasn't moved much in the days leading up to Wednesday's game. A winning bet on Atletico Madrid is sure to deliver a nice profit, but such a play is too risky against a Barcelona team clicking on all cylinders. 


🆚 Barcelona vs. Atletico Madrid projected lineups

Here are Wednesday's projected lineups for Barcelona vs. Atletico Madrid; lineups subject to change:

Barcelona Atletico Madrid
Garcia Musso
Cancelo Ruggeri
Cubarsi Normand
Martin Hancko
Kounde Molina
Pedri Simeone
Garcia Llorente
Rashford Koke
Lopez Lookman
Yamal Alvarez
Lewandowski Griezmann

📈 Barcelona vs. Atletico Madrid betting trends

Barcelona Statistic Atletico Madrid
6-2-2 Season record 6-2-4
115-57-78 H2H record 78-57-115
D-W-W-W-W Last 5 games (all comps) W-W-L-L-L
Won 2-1 vs. Atletico Madrid Previous result Lost 2-1 vs. Barcelona
Barcelona have scored more Champions League goals than any other team (73) since Flick took charge last season. Key stat Atletico have never won a Champions League away game against Spanish opposition.

The odds suggest that Barcelona could be in for a dogfight at home against an opponent that's historically difficult to break down. 

Beating Atletico twice in the same week is a feat that few teams could manage. But if there's one team built to do it, it's Barcelona.

Diego Simeone will have made adjustments in the days since falling at home to Barcelona, but the Catalan side is going to overwhelm Atletico Madrid and put on a show during the first major European night since the Camp Nou reopened following extensive renovations.


🌤️ Barcelona vs. Atletico Madrid weather

It should be a comfortable evening when Camp Nou hosts Wednesday's Champions League quarterfinal. The temperature in Barcelona is expected to be around 60 degrees at kick-off, with zero chance of rain.


📺 How to watch Barcelona vs. Atletico Madrid

  • Date: Wednesday, April 8
  • Kickoff: 3 p.m. ET
  • Location: Camp Nou (Barcelona, Spain)
  • TV: Paramount+

❓ Barcelona vs. Atletico Madrid FAQ

Who is favored to win Barcelona vs. Atletico Madrid?

Barcelona are a -185 betting favorite against Atletico Madrid on Wednesday.

Who is the best Barcelona vs. Atletico Madrid bet?

The best bets for Barcelona vs. Atletico Madrid include Robert Lewandowski to score (+100).

Where to watch Barcelona vs. Atletico Madrid in the U.S. and Canada?

You can watch Barcelona vs. Atletico Madrid on Paramount+ in the United States, or stream the game on DAZN in Canada.