NFL Predictions Week 1: Best Bets & Odds for Chiefs vs. Chargers and Every Game

Game 1 of the 2025 season is in the books but our NFL predictions keep on rolling with tonight's Kansas City Chiefs vs. Los Angeles Chargers matchup in Sao Paulo, Brazil, and our NFL picks have you covered straight through Monday Night Football between the Minnesota Vikings and Chicago Bears.

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🏈 NFL predictions for Week 1

Here are all of our NFL expert picks for Week 1, which we'll update throughout the week based on the odds at our best sports betting sites.

• Chiefs vs. Chargers prediction
• Chiefs vs. Chargers player props
• Chiefs vs. Chargers parlay picks
• Chiefs vs. Chargers anytime touchdown scorer predictions
• Chiefs vs. Chargers first touchdown scorer predictions
• Ravens vs. Bills prediction
• Early Ravens vs. Bills prediction
• Ravens vs. Bills player props
• Ravens vs. Bills parlay picks
• Lamar Jackson vs. Josh Allen player props
• Ravens vs. Bills anytime touchdown scorer predictions
• Ravens vs. Bills first touchdown scorer predictions
• Vikings vs. Bears prediction
• Early Vikings vs. Bears prediction
• Steelers vs. Jets player props
• Giants vs. Commanders player props
• Titans vs. Broncos player props
• Lions vs. Packers player props

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💰 NFL odds & expert picks: Week 1

Live NFL odds for every Week 1 game; updated in real time. Expert picks added throughout the week.

📊 Chiefs vs. Chargers odds

• Date: Friday, Sept. 5
• Kickoff: 8 p.m. ET
• Location: Arena Corinthians (Sao Paulo, Brazil)
• How to watch: YouTube

🔮 Chiefs vs. Chargers prediction: Chargers +3.5

Here's an excerpt from our Chiefs vs. Chargers prediction on why Mike Spector expects the Chargers to cover the spread:

"This is the kind of game that Chargers head coach Jim Harbaugh lives for. Kansas City is not likely to blow the doors off the Chargers offensively, coming off a season where it ranked 31st in explosive plays (75), 23rd in yards per play (5.1), and 29th in yards per rush."

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📊 Buccaneers vs. Falcons odds

• Date: Sunday, Sept. 7
• Kickoff: 1 p.m. ET
• Location: Mercedes-Benz Stadium (Atlanta)
• How to watch: FOX

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📊 Raiders vs. Patriots odds

• Date: Sunday, Sept. 7
• Kickoff: 1 p.m. ET
• Location: Gillette Stadium (Foxborough, Mass.)
• How to watch: CBS

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📊 Bengals vs. Browns odds

• Date: Sunday, Sept. 7
• Kickoff: 1 p.m. ET
• Location: Huntington Bank Field (Cleveland)
• How to watch: FOX

🔮 Bengals vs. Browns prediction: Browns +6

Here's why Liam Fox is predicting the Browns to cover the spread against the Bengals on Sunday:

"Cincinnati has had some trouble with the Browns in the recent past and certainly struggles with slow starts to the regular season. I like the Browns, led by veteran QB Joe Flacco, to keep this one close at home."

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📊 Cardinals vs. Saints odds

• Date: Sunday, Sept. 7
• Kickoff: 1 p.m. ET
• Location: Caesars Superdome (New Orleans)
• How to watch: CBS

🔮 Cardinals vs. Saints prediction: Cardinals -5.5

Here's why Gary Pearson is predicting the Cardinals to cover the spread against the Saints:

"The New Orleans Saints' quarterback situation reminds me of Shakespearean tragedy, only without the intrigue. I have no faith in whoever Kellen Moore names as his starting quarterback. While it's a large spread to cover on the road, the Arizona Cardinals have enough weapons to dominate a Saints team that will struggle to score."

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📊 Steelers vs. Jets odds

• Date: Sunday, Sept. 7
• Kickoff: 1 p.m. ET
• Location: MetLife Stadium (East Rutherford, N.J.)
• How to watch: CBS

🔮 Steelers vs. Jets prediction: Under 37.5

Here's why Dustin Saracini is predicting Steelers-Jets to finish Under the projected total:

"We have one of the best scoring defenses in the league last year in the Pittsburgh Steelers going against a team that will be living on the ground. With Justin Fields as QB1, the Jets will be churning the clock all year long and will find it difficult to score against the strong front seven of Pittsburgh." 

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📊 Dolphins vs. Colts odds

• Date: Sunday, Sept. 7
• Kickoff: 1 p.m. ET
• Location: Lucas Oil Stadium (Indianapolis)
• How to watch: CBS

🔮 Dolphins vs. Colts prediction: Dolphins ML

Here's why Dustin Saracini is predicting the Dolphins to beat the Colts outright:

"The Colts might be one of the worst teams in the NFL this year, and they're opening as favorites against a team with playoff aspirations. Miami's secondary could use a facelift, but the addition of Matthew Judon, the return of Jaelen Phillips, and the anchor that is Minkah Fitzpatrick should be enough to stop an offense led by Daniel Jones. I'm letting Tua and Co. take over on their side of the ball. This is a Dolphins W."

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📊 Panthers vs. Jaguars odds

• Date: Sunday, Sept. 7
• Kickoff: 1 p.m. ET
• Location: EverBank Stadium (Jacksonville, Fla.)
• How to watch: FOX

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📊 Giants vs. Commanders odds

• Date: Sunday, Sept. 7
• Kickoff: 1 p.m. ET
• Location: Northwest Stadium (Landover, Md.)
• How to watch: FOX

🔮 Giants vs. Commanders prediction: Commanders -6.5

Here's why Dustin Saracini is predicting the Commanders to cover the spread against the Giants:

"Washington is laying just 6.5 points against one of the worst teams in the NFL last season. It'll be all systems go for the Commanders in Week 1 after finally locking up Terry McLaurin, who will be the Batman to Deebo Samuel's Robin this year. The Commanders were a top-six scoring offense a year ago, and only got better in the offseason. They'll be up against a Giants defense that allowed 346 yards per game last year. Look for Jayden Daniels to have his way with a new assortment of toys at his disposal." 

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📊 49ers vs. Seahawks odds

• Date: Sunday, Sept. 7
• Kickoff: 4:05 p.m. ET
• Location: Lumen Field (Seattle)
• How to watch: FOX

🔮 49ers vs. Seahawks prediction: Zach Charbonnet to score a touchdown

Here's why Liam Fox is predicting Seahawks running back Zach Charbonnet to score a touchdown against the 49ers on Sunday:

"Charbonnet looked great in training camp and in his lone preseason appearance. There's been buzz that he could push Kenneth Walker for the Seahawks' RB1 role, and I think he gets off to a great start against a 49ers team that allowed the second-most rushing touchdowns in the league last season."

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📊 Titans vs. Broncos odds

• Date: Sunday, Sept. 7
• Kickoff: 4:05 p.m. ET
• Location: Empower Field at Mile High (Denver)
• How to watch: FOX

🔮 Titans vs. Broncos prediction: Broncos -7.5

Here's why Gary Pearson is predicting the Broncos to cover the spread against the Titans:

"This represents an incredibly challenging situation for No. 1 draft pick Cam Ward. He faces an away visit in the Mile High City, where the Broncos were 6-2 ATS last season, against one of the league's best defenses. Talk about a baptism of fire." 

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📊 Lions vs. Packers odds

• Date: Sunday, Sept. 7
• Kickoff: 4:25 p.m. ET
• Location: Lambeau Field (Green Bay, Wis.)
• How to watch: CBS

🔮 Lions vs. Packers prediction: Lions ML

Here's why Dustin Saracini is predicting the Lions to beat the Packers:

"The highest-scoring offense in the NFL a year ago is somehow an underdog going into Week 1. We will be riding Jared Goff and Jahmyr Gibbs to the bank. Don't miss out."

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📊 Texans vs. Rams odds

• Date: Sunday, Sept. 7
• Kickoff: 4:25 p.m. ET
• Location: SoFi Stadium (Inglewood, Calif.)
• How to watch: CBS

🔮 Texans vs. Rams prediction: Over 44.5

Here's why Dustin Saracini is predicting Texans-Rams to finish Over the projected total:

"The number is set far too low with two of the most explosive offenses in football going head-to-head. With Joe Mixon likely out for Week 1, the Houston faithful will see just how much Nick Chubb has in the tank, while Davante Adams makes his Rams debut. Get set for fireworks in this one."  

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📊 Ravens vs. Bills odds

• Date: Sunday, Sept. 7
• Kickoff: 8:20 p.m. ET
• Location: Highmark Stadium (Orchard Park, N.Y.)
• How to watch: NBC

🔮 Ravens vs. Bills prediction: Over 51.5

Here's an excerpt from our Ravens vs. Bills early prediction on why Mike Spector predicts an offensive showcase in Orchard Park:

"This is a matchup of the only two teams that had 11 or more 30-point games last season. So while much has been made of neither team’s quarterback playing at all in the preseason, I am excited to back this under-inflated line in a matchup of the last two MVP winners."

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📊 Vikings vs. Bears odds

• Date: Monday, Sept. 8
• Kickoff: 8:15 p.m. ET
• Location: Soldier Field (Chicago, IL)
• How to watch: ABC

🔮 Vikings vs. Bears prediction: Under 43.5

Here's an excerpt from our Vikings vs. Bears prediction on why Gary Pearson predicts Vikings-Bears to finish Under the projected total on Monday night:

"McCarthy makes his regular-season debut on the road in a hostile environment against a Bears defense that last season received the 10th-best coverage rating, according to PFF. While it wasn't an elite unit overall, the defense was the only reason Chicago didn't lose more than 12 games."

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💡 NFL expert picks for Week 1

• NFL picks against the spread Week 1
• NFL QB clutch player ratings Week 1
• NFL fantasy pickup player props Week 1
• NFL rookie player props Week 1
• NFL trends that matter Week 1
• NFL weather report Week 1
• NFL survivor picks Week 1
• NFL upset picks Week 1
• NFL betting guide: How to bet Week 1 on a $100 budget
• NFL long-shot parlay Week 1
• NFL live betting guide Week 1
• NFL moneyline picks Week 1
• NFL AI predictions Week 1
• NFL player props Week 1
• NFL Watchability Index Week 1
• NFL expert picks Week 1 (coming soon)
• NFL anytime touchdown scorer predictions Week 1 (coming soon)
• NFL anytime touchdown scorer parlay Week 1 (coming soon)
• NFL best bets Week 1 (coming soon)

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