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Trevor Lawrence of the Jacksonville Jaguars looks to pass as we share our best Bengals vs. Jaguars parlay for MNF.
Trevor Lawrence of the Jacksonville Jaguars looks to pass against the Los Angeles Chargers at SoFi Stadium in Inglewood, California. Photo by Sean M. Haffey/Getty Images via AFP.

The winless Houston Texans enter their Week 5 clash with the rival Jacksonville Jaguars as big underdogs once again. Check out our top Texans-Jaguars picks below.

The Jaguars suffered a 29-21 loss in bad weather against the Philadelphia Eagles last week. That snapped a two-game winning streak for new head coach Doug Pederson.

Houston has lost three straight games since a season-opening tie with the Indianapolis Colts. The Texans have won eight straight meetings with the Jaguars but oddsmakers expect that to change in Week 5.

Check out our NFL best bets and all of our top Week 5 picks.

Here are our top Texans-Jaguars Week 5 NFL picks (odds via DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Texans vs. Jaguars Game Info

  • Date: Sunday, Oct. 9, 1 p.m. ET
  • TV: CBS
  • Location: TIAA Bank Field, Jacksonville, FL
  • Weather: 82 degrees, 7% chance of precipitation, 9-mph winds

Texans vs. Jaguars Odds

Texans vs. Jaguars Odds Analysis

There has been no movement on the consensus betting lines for this Week 5 matchup of AFC South rivals despite heavily lopsided action. The Jaguars have drawn 80% of the handle on 82% of the tickets while the Over has received 79% of the handle on 74% of the tickets.

Texans vs. Jaguars Picks

  • Spread: Jaguars -7 (-110 via DraftKings) ★★★★★
  • Over/Under: Over 43.5 (-105 via DraftKings) ★★★★★
  • Prop: James Robinson anytime TD scorer (+100 via DraftKings) ★★★★★

Texans vs. Jaguars ATS Pick

Jaguars -7 (-110) ★★★★★

It’s hard to imagine a scenario where the Jags don’t absolutely feast in this matchup. Their improved passing game has made headlines, but where they can really win is on the ground. The Texans have given up a whopping 172 rushing yards per game, a juicy statistic for a Jacksonville team boasting two explosive running backs, James Robinson and Travis Etienne.

Houston’s defense will need to cheat a bit while respecting Lawrence’s ability to connect through the air, which should open up a ton of room for rushing. All-in-all, this contest should be a Jacksonville slam dunk, with no trouble piling up points in every way.

Texans vs. Jaguars O/U Pick

Over 43.5 (-105) ★★★★★

The total's slight rise since opening is telling, which makes sense as a few different avenues lead to a successful Over wager. The Texans may have lost last week, but they still put up 24 points against the Chargers and should score their fair share.

On the other hand, Jacksonville is in a spot to shred. This is the first season in several where both the run and pass are viable options, leaving Houston with its hands full against an offense that already scored 105 points through four games. The Jaguars have been decent defensively,  but they’re still allowing roughly 94 rushing yards against per game, meaning Texans’ RBs Pierce and Rex Burkhead can do some potential damage.

Texans vs. Jaguars Prop Pick

Robinson anytime TD scorer (+100) ★★★★★

What a return it's been for Robinson, a 24-year-old who tore his left Achilles tendon in December 2021. Some experts wondered whether he'd be back at all in 2022, but he quickly shut down all of those concerns with 259 rushing yards and three touchdowns through four matchups.

As previously noted, the Texans are horrendous at stopping the run. Just ask Chicago Bears’ second-string back Khalil Herbert, who completely torched Houston’s D with 157 rushing yards and two TDs on just 20 carries during Week 3. The chances of Robinson finding pay dirt are very high, even if Etienne gets some more runway as well.

Where to Bet on Texans vs. Jaguars Picks

Here are our top-rated sportsbooks:

Texans-Jaguars picks made 10/07/2022 at 1:17 p.m. ET