Steelers vs. Chargers Prediction & Opening Odds for Sunday Night Football: NFL Week 10

My Steelers vs. Chargers prediction and early picks for Sunday Night Football at SoFi Stadium in Inglewood, Calif., expect Pittsburgh's pass rush to enjoy a successful day at the office against a depleted Los Angeles' offensive line.t

The opening odds after Sunday's results have the Chargers as the 3-point betting favorite for SNF, which starts at 8:20 p.m. ET (NBC). The pick below is part of the NFL predictions for Week 10.

🏈 Early Steelers vs. Chargers prediction & betting preview

Stay ahead with the rest of our early NFL picks for Week 10.

🏗️ Steelers +3 (-105) ⭐⭐⭐

In a vacuum, the Chargers should be the better football team.

However, this matchup suits the Steelers with the most recent developments, including two significant injury blows to the Chargers' offensive line.

Just as the unit was returning to full health, disaster struck twice in Tennessee, with left tackle Joe Alt re-injuring his ankle and right tackle Bobby Hart sustaining groin and ankle injuries. 

Justin Herbert was sacked six times against the Titans, and he'll be facing a formidable pass rush that enjoyed its best game of the season against the Indianapolis Colts.

Turnover-prone Chargers face turnover-specialist defense

The Steelers' defense forced eight fumbles through the first eight weeks, most in the NFL, and eight interceptions, tied for the sixth most.

That was before adding three fumbles and three picks in Week 9 against a Colts' offense that rarely commits mistakes. The Steelers had the eighth-highest pressure rate (22.7%) and the fifth-highest blitz rate (29%) before playing Indy in Week 9, in which they sacked Daniel Jones five times. 

Herbert, meanwhile, had thrown the third-most interceptions (8), tied with Joe Flacco and Jake Browning, before tossing a pick-six against the Titans.

If Alt and Hart don't win the race against time, a likely outcome, Herbert could be in for a world of hurt against a Steelers' defense with newfound confidence and self-belief.

FanDuel and DraftKings offer odds of -105, which imply a 51.22% probability. Those odds provide the best value, and a winning $10 bet will profit $9.52. 

📊 Live Steelers vs. Chargers odds: Week 10

See the latest NFL odds for every game in Week 10. 

🔢 Steelers vs. Chargers opening odds

• Moneyline: Steelers +145 | Chargers -175
• Spread: Steelers +3.5 (-115) | Chargers -3.5 (-105)
• Over/Under: Over 45.5 (-110) | Under 45.5 (-110)

↔️ Steelers vs. Chargers line movement

At DraftKings, the Chargers are receiving -115 odds for their -3 spread. That shorter line indicates the Chargers could move to -3.5 at DraftKings and potentially more of the best sports betting sites. 

📈 Steelers vs. Chargers trends & betting notes: SNF

• The Steelers are 4-4 ATS
• The Chargers are 3-5-1 ATS
• The Chargers are tied for the eighth-worst turnover margin per game (-0.4)
• The Steelers have the second-best turnover margin per game (+1.1)

📺 How to watch Steelers vs. Chargers: Sunday Night Football

• Date: Sunday, Nov. 9
• Kickoff: 8:20 p.m. ET
• Location: SoFi Stadium (Inglewood, Calif.)
• TV: NBC