Seahawks vs. Cardinals Player Prop Bets for Thursday Night Football: TNF Odds & Picks

After nailing two of my three Thursday Night Football picks last week, I’m gunning for a clean sweep with my best Seahawks vs. Cardinals player prop bets for this intriguing NFC West battle from State Farm Stadium in Glendale, Ariz. (8:20 p.m. ET, Prime Video).

Among my trio of TNF prop bets are plays on both starting quarterbacks - Arizona’s Kyler Murray and Seattle’s Sam Darnold. The latter’s team is a consensus 1.5-point betting favorite on the road, as the line flipped midweek from Cardinals -1.

These NFL picks are part of a slew of NFL predictions for Week 4 that we’re offering up. And of course, we have a comprehensive breakdown of this matchup, including the latest live odds and our official Seahawks vs. Cardinals prediction.

🏈 Best Seahawks vs. Cardinals player props: Thursday Night Football

NFL player prop bets based on the latest Thursday Night Football odds.

• Sam Darnold Over 219.5 passing yards (-115 via BetMGM) ⭐⭐⭐⭐
• Kyler Murray Over 27.5 rushing yards (-114 via FanDuel) ⭐⭐⭐
• Kenneth Walker III Under 52.5 rushing yards (-112 via DraftKings) ⭐⭐⭐

💰 Best Thursday Night Football player prop bets

Our NFL player prop odds tool shows the best odds for every market across legal sportsbooks in your area.

⬆️ Sam Darnold Over 219.5 passing yards (-115) ⭐⭐⭐⭐

Not surprisingly, the Cowboys have the worst pass defense in the NFL — they’re allowing 288 air yards per game, 22 more than Baltimore. Next up? Arizona, which is yielding 264.3 passing yards per contest. That’s not the most disturbing part, though. This is: The Cardinals have faced Spencer Rattler, Bryce Young and Mac Jones, three below-average QBs who respectively threw for 214, 328 and 284 yards.

As you’ll see momentarily, I don’t think the Seahawks will have success running the ball (Arizona’s front seven is stout). Rather, I expect Sam Darnold to carve up the Cardinals’ leaky secondary — the same Darnold who has tallied at least 231 passing yards in 13 of his last 16 outings (playoffs included).

BetMGM offers the best number and odds (-115) on this Seahawks vs. Cardinals prop, which carries a 53.49% implied win probability. A winning $10 wager would return $8.70.

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⬆️ Kyler Murray Over 26.5 rushing yards (-115) ⭐⭐⭐

Thus far, the Seahawks’ defense has faced Brock Purdy, Aaron Rodgers and Spencer Rattler — otherwise known as three guys who have never won a 40-yard dash. So I’m not giving Seattle a standing ovation for holding that trio to 30 total rushing yards on eight carries.

Things change on Thursday Night Football, when that same defense has to chase Kyler Murray around the field for 60 minutes. The Cardinals’ QB has hurdled his rushing projection in all three games to start the season, tallying 107 total yards on just 20 carries. What’s more, Murray has hit this prop in five of his last six games dating to last season. He’s also cleared 27 rushing yards in seven of 10 career meetings against the Seahawks.

Tail this bet at FanDuel, whose -114 odds equate to a 53.27% implied win probability. A $10 wager could win $8.77.

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⬇️ Kenneth Walker III Under 52.5 rushing yards (-112) ⭐⭐⭐

Seahawks running back Kenneth Walker trampled what is quickly proving to be an overrated Steelers defense in Week 2, gaining 105 yards on just 13 carries. Otherwise, though, Walker has produced a total of 56 ground yards on 26 carries (a paltry 2.1 yards per rush).

To be fair, Walker has had his way with the Cardinals so far in his career, rushing for 430 yards in five games. However, his output has declined in the last four meetings (109, 105, 78 and 41 yards). Those latter two totals are from 2024, when Arizona ranked 20th in rushing defense (126.4 ypg). So far this year? The Cardinals are fourth against the run (76.3 ypg).

Head over to DraftKings and risk $10 for a chance to win $8.93 on this Seahawks vs. Cardinals prop. At -112 odds, this one has an implied win probability of 52.83%.

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📺 How to watch Thursday Night Football

• When: Thursday, Sept. 25
• Kickoff: 8:15 p.m. ET
• Where: State Farm Stadium (Glendale, Ariz.)
• How to watch: Prime Video

❓ Thursday Night Football FAQs

What are the best player props for Thursday Night Football?

The best player prop bets for Thursday Night Football are Sam Darnold Over 219.5 passing yards, Kyler Murray Over 27.5 rushing yards and Kenneth Walker III Under 52.5 rushing yards.

When is Thursday Night Football?

Thursday Night Football kicks off at 8:15 p.m. ET on Sept. 25, and will air live on Prime Video.

How do NFL player props work?

Player props are wagers on individual performances rather than the outcome of the game. Common props found at our best NFL prop betting sites include passing yards, rushing yards, receiving yards, and touchdown scorers. For example, if a QB’s passing yards line is set at 250.5, you can bet the Over (251-plus yards) or Under (250 or fewer yards). You can also bet on if a specific player will score a touchdown in the entire game, the first or last touchdown, and more NFL odds markets.

You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.

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