Rams vs. Jaguars Prediction & Odds Today: NFL Week 7 Best Bets, Picks for London

Last Updated: October 19, 2025 6:27 AM EDT • 3 minute read X Social Google News Link

The Los Angeles Rams and Jacksonville Jaguars square off this morning at Wembley Stadium in London (9:30 a.m. ET, NFL Network/NFL+), and my Rams vs. Jaguars prediction backs the Under.
These NFL picks also expect the betting favorite Rams (-148) to win. For extensive coverage on the forthcoming slate of games, check out our NFL predictions for Week 7.
🏈 Rams vs. Jaguars prediction
NFL expert picks for Week 7; odds subject to change.
- Game prediction: Rams ML (-148 via FanDuel) ⭐⭐⭐⭐
- Over/Under pick: Under 44.5 (-104 via Caesars) ⭐⭐⭐⭐
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🆚 Who will win Rams vs. Jaguars?
Sean McVay’s teams are 2-0 straight up and against the spread in International Series games, winning by a combined score of 57-10 and covering the spread by an average of 16 points per outing. I trust the Rams more to win what should be a low-scoring affair.
Score prediction: Rams 21-Jaguars 20
✅ Best Rams vs. Jaguars bet
Track the latest NFL scores for line movement and matchup info.
⬇️ Under 44.5 (-104) ⭐⭐⭐⭐
Matthew Stafford is 11-0 against teams that field a bottom-five pass defense like the Jaguars since being traded to the Rams in 2021. But Jacksonville's unit is also an opportunistic defense that leads the league with 14 takeaways and allows 20 points per game, which is on pace for the club's fewes since 2018.
Rams’ offensive concerns without Nakua
Nacua has officially been ruled out for this game due to an ankle injury suffered last week.
The impact of Nacua’s absence cannot be understated, as he leads the team in receptions (54) and receiving yards (616). His 57 touches are also more than double that of No. 2 wide receiver Davante Adams (26).
Los Angeles is 12-5 with a healthy Nacua over the last two seasons, while its quarterbacks have totaled a 30:7 passing touchdown-to-interception ratio. The team's signal-callers have also taken sacks just 4% of the time while averaging a plus-4.9 Offensive EPA per game.
However, the Rams are 2-4 without Nakua, and their quarterbacks are posting a 4:4 passing touchdown-to-interception ratio. They've also taken sacks 9% of the time while averaging a minus- 0.8 offensive EPA per outing.
Adams and Stafford need to work on their chemistry if he becomes the primary target by default, as the quarterback has been off target on 30% of the passes thrown the receiver's way this season. We actually highlight a couple other Rams who might take advantage of the extra targets in our Rams vs. Jaguars player props and Rams. vs. Jaguars anytime touchdown scorer predictions.
Neither team holds great momentum heading into this game. The Jaguars are coming off season lows in points, yards, and rushing yards, while the Rams put up lows in yards, passing yards, and first downs during last week’s win.
Caesars is posting the lowest juice among the best sports betting sites that are offering a total of 44.5, as its -104 odds come with a 50.98% implied probability. If the Under does cash, a $10 winning wager would net $9.62 in profit.
📊 Rams vs. Jaguars odds
Latest NFL odds updated live in real time.
🔢 Rams vs. Jaguars updated betting insights
- The Rams opened as the 3.5-point betting favorite. That line has since decreased to -3
- 56% of bets back the Jaguars to cover
- The total opened at 47.5, but has since decreased to 45.5. Bettors are split down the middle, with 50% on either side
📺 How to watch Rams vs. Jaguars
- Date: Sunday, Oct. 19
- Kickoff: 9:30 a.m. ET
- Where: Wembley Stadium, (London)
- TV: NFL Network/NFL+
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