Raiders vs. Broncos Prediction & Opening Odds for Thursday Night Football: NFL Week 10

The AFC West-leading Denver Broncos (7-2) host the Las Vegas Raiders (2-6) at Empower Field at Mile High for Thursday Night Football, and my Raiders vs. Broncos prediction and early picks back Sean Payton's team to win their seventh straight in comprehensive fashion. 

The opening odds in the aftermath of Sunday's games have the Broncos as the 9.5-point betting favorite. The pick below is part of the Week 10 NFL predictions, with Thursday's game starting at 8:15 p.m. ET (Prime Video). 

🏈 Early Raiders vs. Broncos prediction & betting preview

Stay ahead with the rest of our early NFL picks for Week 10.

🐎 Broncos -9.5 (-110) ⭐⭐⭐⭐

Don't let the Raiders' near miss at home against the Jacksonville Jaguars deter you. The Broncos have reeled off six successive wins and had the fifth-best defensive DVOA and the fourth-best defensive EPA per play before holding the Houston Texans to 268 total yards of offense.

Admittedly, the Texans were without C.J. Stroud for most of the game, but that doesn't alter the fact that Denver has the decisive advantage on both sides of the ball.

Raiders get raided on the road

The Raiders have been competitive in Sin City, but the same cannot be said when they hit the road. Pete Carroll's team lost the last three road games by an average margin of 27.3 points, allowing 384 yards of total offense against per game.  

Meanwhile, the Raiders' offense averaged only 248 yards in those defeats against mostly mediocre defenses. Before facing the Jaguars in Week 9, the Raiders had the 30th-ranked offensive DVOA and the 29th-ranked offensive EPA per play.

While Brock Bowers' return to the lineup is somewhat disconcerting, the Broncos' defense is as elite as they come, and Vance Joseph's unit should do a much better job at minimizing his impact than Jacksonville did. 

FanDuel and BetMGM offer -110 odds, the best value among the best sports betting sites. A winning bet at those sportsbooks will profit $9.09 on a winning $10 bet, with an implied probability of 52.38%.

📊 Live Raiders vs. Broncos odds: Week 10

See the latest NFL odds for every game in Week 10.

🔢 Raiders vs. Broncos opening odds

• Moneyline: Raiders +260 | Broncos -325
• Spread: Raiders +6.5 (-110) | Broncos -6.5 (-110)
• Over/Under: Over 43.5 (-110) | Under 43.5 (-110)

↔️ Raiders vs. Broncos line movement

The Broncos' -9.5 will likely increase in the days leading up to Thursday's kickoff. DraftKings has already moved to -10, the only one among the best sports betting apps offering that higher number.

Caesars offers -9.5 at -113, showing early signs of pushing the line toward -10. The fact that 73% of public bets back Denver also preempts the move to -10. 

📈 Raiders vs. Broncos trends & betting notes: TNF

• The Broncos are 4-4-1 ATS
• The Raiders are 3-5 ATS and 1-3 ATS on the road
• The Broncos won the last two meetings, both by at least 10 points
• The Raiders scored six points in their last two road games

📺 How to watch Raiders vs. Broncos: Thursday Night Football

• Date: Thursday, Nov. 6
• Kickoff: 8:15 p.m. ET
• Location: Empower Field at Mile High (Denver)
• TV: Prime Video