NFL Predictions Week 6: Best Bets & Odds for Every Game
There are no undefeated teams left in the NFL after five weeks, and our NFL predictions for Week 6 expect parity to reign supreme yet again as we offer our NFL picks with the latest live odds for every game - from Eagles vs. Giants on Thursday Night Football all the way through the Monday Night Football doubleheader.
🏈 NFL predictions for Week 6
- Eagles vs. Giants prediction (coming soon)
- Eagles vs. Giants early prediction
- Eagles vs. Giants player props (coming soon)
- Eagles vs. Giants parlay picks (coming soon)
- Eagles vs. Giants anytime touchdown scorer predictions (coming soon)
- Eagles vs. Giants first touchdown scorer predictions (coming soon)
- Eagles vs. Giants expert picks (coming soon)
- Broncos vs. Jets prediction (coming soon)
- Broncos vs. Jets early prediction
- Broncos vs. Jets player props (coming soon)
- Broncos vs. Jets anytime touchdown scorer predictions (coming soon)
- Chargers vs. Dolphins player props (coming soon)
- Browns vs. Steelers player props (coming soon)
- Rams vs. Ravens player props (coming soon)
- Bengals vs. Packers player props (coming soon)
- 49ers vs. Buccaneers player props (coming soon)
- Lions vs. Chiefs prediction (coming soon)
- Lions vs. Chiefs early prediction (coming soon)
- Lions vs. Chiefs player props (coming soon)
- Lions vs. Chiefs parlay picks (coming soon)
- Lions vs. Chiefs anytime touchdown scorer predictions (coming soon)
- Lions vs. Chiefs first touchdown scorer predictions (coming soon)
- Lions vs. Chiefs expert picks (coming soon)
- Bills vs. Falcons prediction (coming soon)
- Bills vs. Falcons early prediction (coming soon)
- Bills vs. Falcons player props (coming soon)
- Bills vs. Falcons parlay picks (coming soon)
- Bills vs. Falcons anytime touchdown scorer predictions (coming soon)
- Bills vs. Falcons first touchdown scorer predictions (coming soon)
- Bills vs. Falcons expert picks (coming soon)
- Bears vs. Commanders prediction (coming soon)
- Bears vs. Commanders early prediction (coming soon)
- Bears vs. Commanders player props (coming soon)
- Bears vs. Commanders parlay picks (coming soon)
- Bears vs. Commanders anytime touchdown scorer predictions (coming soon)
- Bears vs. Commanders first touchdown scorer predictions (coming soon)
- Bears vs. Commanders expert picks (coming soon)
💰 NFL odds & expert picks: Week 6
Live NFL odds for every Week 6 game; updated in real time.
📊 Eagles vs. Giants odds
- Date: Thursday, Oct. 9
- Kickoff: 8:15 p.m. ET
- Location: MetLife Stadium (East Rutherford, N.J.)
- How to watch: Prime Video
🔮 Early Eagles vs. Giants prediction
🗽 Giants +7.5 (-115)
This is less about the Giants - who fell back down to Earth in Jaxson Dart's second start - and more about the Eagles, whose five games this year have all been decided by seven points or fewer. I'm expecting a close affair on a short week for these NFC East rivals.
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📊 Broncos vs. Jets odds
- Date: Sunday, Oct. 12
- Kickoff: 9:30 a.m. ET
- Location: Tottenham Hotspur Stadium (London)
- How to watch: NFL Network
🔮 Early Broncos vs. Jets prediction
🐎 Broncos -7 (-110)
This might feel like a buy-high on the Broncos, but I simply can't bet the Jets in good conscience with how awful they've looked on both sides of the ball. I expect Denver's defense to make Justin Fields' life miserable for 60 minutes in London.
📊 Cardinals vs. Colts odds
- Date: Sunday, Oct. 12
- Kickoff: 1 p.m. ET
- Location: Lucas Oil Stadium (Indianapolis)
- How to watch: FOX
🔮 Early Cardinals vs. Colts prediction
🐴 Colts -5.5 (-108)
The Cardinals have a nasty habit of letting every opponent catch fire in the second half, and the Colts have been blowing out lesser competition with ease. I don't expect this one to be close.
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📊 Rams vs. Ravens odds
- Date: Sunday, Oct. 12
- Kickoff: 1 p.m. ET
- Location: M&T Bank Stadium (Baltimore)
- How to watch: FOX
🔮 Early Rams vs. Ravens prediction
🐦⬛ Ravens +8 (-110)
We all saw how pitiful the Ravens looked in that blowout loss to the Texans, but this is simply too many points for a group that should return some of its All-Pro talent in Week 6. That's enough for me to take the points on the home side against the Rams, who have seen four of five games decided by seven or fewer points.
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📊 Cowboys vs. Panthers odds
- Date: Sunday, Oct. 12
- Kickoff: 1 p.m. ET
- Location: Bank of America Stadium (Charlotte, N.C.)
- How to watch: FOX
🔮 Early Cowboys vs. Panthers prediction
🤠 Cowboys -3.5 (-105)
Even after a comeback win against the Dolphins, I'm not convinced that the Panthers aren't the worst team in the NFL. The Cowboys are quietly efficient offensively and should be able to keep Bryce Young in check enough to cover a meager number.
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📊 Browns vs. Steelers odds
- Date: Sunday, Oct. 12
- Kickoff: 1 p.m. ET
- Location: Acrisure Stadium (Pittsburgh)
- How to watch: CBS
🔮 Early Browns vs. Steelers prediction
🐶 Browns +5.5 (-115)
Dillon Gabriel isn't the long-term answer for Cleveland, but he's efficient enough in the short game to give the Browns a chance behind a truly elite defense. This is too many points in a compelling AFC North showdown.
📊 Seahawks vs. Jaguars odds
- Date: Sunday, Oct. 12
- Kickoff: 1 p.m. ET
- Location: EverBank Stadium (Jacksonville, Fla.)
- How to watch: CBS
🔮 Early Seahawks vs. Jaguars prediction
🟢 Seahawks +1 (-115)
I'm all-in on the Seahawks, who sneakily rank in the top five in point differential (+41) and should have a better defensive effort after a blistering loss to the Bucs. This feels like a chance for Mike Macdonald to flex his coaching might against an inconsistent Jaguars offense.
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📊 Chargers vs. Dolphins odds
- Date: Sunday, Oct. 12
- Kickoff: 1 p.m. ET
- Location: Hard Rock Stadium (Miami Gardens, Fla.)
- How to watch: CBS
🔮 Early Chargers vs. Dolphins prediction
⚡️ Chargers -4.5 (-118)
The Chargers have lost two straight in inexplicable fashion, but I'd be truly shocked if they drop a third straight to the Dolphins, who only look competent against other dumpster fires. Expect Justin Herbert to make an MVP statement against an abhorrent Miami defense.
📊 Patriots vs. Saints odds
- Date: Sunday, Oct. 12
- Kickoff: 1 p.m. ET
- Location: Caesars Superdome (New Orleans)
- How to watch: FOX
🔮 Early Patriots vs. Saints prediction
🪖 Patriots -3 (-105)
Can the Patriots carry the momentum of a monumental win over the Bills into a much easier test this week in New Orleans? I wouldn't bet this north of -3, but I do expect Drake Maye and Co. to beat the one-win Saints and keep pace in the AFC playoff field.
📊 Titans vs. Raiders odds
- Date: Sunday, Oct. 12
- Kickoff: 4:05 p.m. ET
- Location: Allegiant Stadium (Las Vegas)
- How to watch: CBS
🔮 Early Titans vs. Raiders prediction
⚔️ Titans +6.5 (-115)
This is the worst matchup of the week between two teams going nowhere in 2025. That makes it easy to take the points with the Titans, as I simply can't justify laying nearly a touchdown with a 1-4 team coming off a 34-point loss.
📊 49ers vs. Buccaneers odds
- Date: Sunday, Oct. 12
- Kickoff: 4:25 p.m. ET
- Location: Raymond James Stadium (Tampa, Fla.)
- How to watch: FOX
🔮 Early 49ers vs. Buccaneers prediction
⛵️ Buccaneers -2.5 (-120)
Both of these teams enter Week 6 with a 4-1 record, but the Buccaneers have looked like the more impressive team behind a borderline MVP campaign from Baker Mayfield. Whether it's Mac Jones or Brock Purdy under center for San Francisco, I love the Bucs to win at home.
📊 Bengals vs. Packers odds
- Date: Sunday, Oct. 12
- Kickoff: 4:25 p.m. ET
- Location: Lambeau Field (Green Bay, Wis.)
- How to watch: CBS
🔮 Early Bengals vs. Packers prediction
🧀 Packers -14 (-110)
I'd be inclined to stay away from this game because of the gargantuan number. But if I'm betting either side, it sure wouldn't be the Bengals, whose offense is an embarrassment with Jake Browning under center alongside a defense that can't generate any pressure. That's a brutal combo against one of the best teams in the NFC.
📊 Lions vs. Chiefs odds
- Date: Sunday, Oct. 12
- Kickoff: 8:20 p.m. ET
- Location: GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
- How to watch: NBC
🔮 Early Lions vs. Chiefs prediction
🦁 Lions +1.5 (-110)
The Chiefs came alive last week in Xavier Worthy's return, but the Lions have played them well in recent years while looking like a potential juggernaut this season even without their coordinators from last year. I like the Lions to win outright.
📊 Bills vs. Falcons odds
- Date: Monday, Oct. 13
- Kickoff: 7:15 p.m. ET
- Location: Mercedes-Benz Stadium (Atlanta)
- How to watch: ESPN
🔮 Early Bills vs. Falcons prediction
🦬 Bills -4.5 (-110)
The Bills rarely lose two games in a row, and I suspect Josh Allen will have a field day against a Falcons defense that needs pressure to survive on the back end. Unless Michael Penix Jr. plays the game of his life, this will be a tough game for Atlanta to win.
📊 Bears vs. Commanders odds
- Date: Monday, Oct. 13
- Kickoff: 8:15 p.m. ET
- Location: Northwest Stadium (Landover, Md.)
- How to watch: ESPN
🔮 Early Bears vs. Commanders prediction
🎖️ Commanders -4 (-110)
It's hard to know what to expect from the Commanders given how little we've seen them at full strength. I was impressed by last week's win over the Chargers, though, and I'm skeptical of the Bears in a tough road spot against a legitimate contender.
💡 NFL expert picks for Week 6
- NFL picks against the spread Week 6 (coming soon)
- NFL survivor picks Week 6 (coming soon)
- NFL upset picks Week 6 (coming soon)
- NFL weather report Week 6 (coming soon)
- NFL QB clutch player ratings Week 6 (coming soon)
- NFL AI predictions Week 6 (coming soon)
- NFL player props Week 6 (coming soon)
- NFL expert picks Week 6 (coming soon)
- NFL anytime touchdown scorer predictions Week 6 (coming soon)
- NFL anytime touchdown scorer parlay Week 6 (coming soon)
- NFL best bets Week 6 (coming soon)
- NFL long-shot parlay Week 6 (coming soon)
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