Packers vs. Lions Best Bets: Our Expert Picks for NFL Thanksgiving Kickoff
The NFL Thanksgiving slate kicks off soon with the Green Bay Packers (7-3-1) and host Detroit Lions (7-4) facing off from Ford Field today at 1 p.m. ET (FOX). To prepare you for kickoff, we've gathered our Packers vs. Lions best bets from our NFL staff with their expert picks as part of our NFL Thanksgiving predictions.
🏈 Packers vs. Lions best bets & expert picks for Thanksgiving
See all of our NFL picks for every game based on the latest NFL odds.
| Wager type | Best bet | Best odds |
|---|---|---|
| Game prediction | Packers +2.5 | -102 via BetMGM |
| Over/Under pick | Over 48.5 | -115 via DraftKings |
| Best player prop bet | Jordan Love Under 230.5 passing yards | -113 via DraftKings |
| Best anytime TD pick | Josh Jacobs anytime TD | -120 via FanDuel |
| Best first TD pick | Amon-Ra St. Brown first TD | +800 via DraftKings |
💡 More NFL predictions
Want more NFL betting advice? Check out all of our NFL analysis and NFL Week 13 predictions for every game this week.
🔮 Packers vs. Lions prediction
The Packers dominated the Lions when these teams met in Week 1, and while Detroit has played better in the weeks since that loss, our NFL expert Gary Pearson expects the home favorites to suffer a similar fate in today's rematch.
Pearson is particularly skeptical that Lions star Jahmyr Gibbs can replicate his recent success against a stout Packers run defense. He breaks down his best bets in every key market for this NFC North matchup in his Packers vs. Lions prediction.
💵 Thanksgiving predictions
- Game prediction: Packers +2.5 (-102) ⭐⭐⭐
- Over/Under pick: Over 48.5 (-115) ⭐⭐⭐
- Best prop bet: Jahmyr Gibbs Under 74.5 rushing yards (-111) ⭐⭐⭐
🔥 Packers vs. Lions player props
Our NFL expert Matt Jacob is also expecting these defenses to show out on Thanksgiving, and he's fading two of the best players in the NFL at their position while taking a shot on an overlooked speedster for the home favorites.
Jacob is betting the Under on the yardage props for Jordan Love and Amon-Ra St. Brown in tricky matchups for both star players, but he likes Jameson Wlliams' chances to break free for a touchdown today against his division rival. He breaks down all of these bets further in his Packers vs. Lions player props for the first game on Thanksgiving.
Our NFL expert Liam Fox also breaks down his favorite bet on Jahmyr Gibbs with his NFL player props for Thanksgiving. Gibbs is also featured in our Packers vs. Lions AI picks.
💵 Thanksgiving player props
- Jordan Love player prop: Under 230.5 passing yards (-113) ⭐⭐⭐⭐
- Amon-Ra St. Brown player prop: Under 74.5 receiving yards (-113) ⭐⭐⭐
- Jameson Williams player prop: To score anytime touchdown (+180) ⭐⭐
💪 Packers vs. Lions anytime TD pick
Even if both defenses step up today, there are still plenty of stars in action for both sides of this storied NFC North rivalry. And Pearson expects some of the biggest names for either side to reach the end zone to kick off the NFL Thanksgiving slate.
Pearson has his sights set on Packers running back Josh Jacobs to score as his most confident player prop bet for Thanksgiving, but he's circling St. Brown and fellow wide receiver Christian Watson with his favorite Packers vs. Lions anytime touchdown predictions for this Week 13 matchup.
Our NFL expert Esten McLaren also offers his best bet for every team to score today in his anytime touchdown scorer predictions for Thanksgiving. We break down even more of our best bets to score at +500 odds or better with our NFL Thanksgiving long shots.
💵 Thanksgiving anytime TD picks
- Josh Jacobs TD pick: To score anytime TD (-120) ⭐⭐⭐⭐
- Amon-Ra St. Brown TD pick: To score anytime TD (+105) ⭐⭐⭐⭐
- Christian Watson TD pick: To score anytime TD (+215) ⭐⭐⭐
🥇 Packers vs. Lions first TD pick
Our NFL expert Phil Wood offers his best bets for the first touchdown scorer for all three games today on Thanksgiving, and he's backing the Lions' top target to open the scoring for the full holiday slate against a vulnerable Packers defense.
Wood expects St. Brown to be featured early and often for the Lions, who have scored the first touchdown in four of their last five games, with his first touchdown scorer predictions for Thanksgiving.
💵 Thanksgiving first TD pick
- Amon-Ra St. Brown TD pick: To score first TD (+800) ⭐⭐⭐⭐
🚀 Packers vs. Lions same-game parlay
Our NFL expert Brenden Schaeffer has put together his best Packers vs. Lions SGP. He's betting on a high-scoring affair with Williams reaching the end zone and Watson putting up numbers with his Packers vs. Lions same-game parlay for Thanksgiving.
💵 Thanksgiving same-game parlay (SGP)
- 1st leg: Over 48.5 (-110) ⭐⭐⭐⭐
- 2nd leg: Jameson Williams anytime TD (+190) ⭐⭐⭐⭐
- 3rd leg: Christian Watson Over 54.5 receiving yards (-111) ⭐⭐⭐⭐
Best odds: +650 via DraftKings ($10 to win $65)
📺 How to watch Packers vs. Lions: Thanksgiving 2025
- Date: Thursday, Nov. 27
- Kickoff: 1 p.m. ET
- Location: Ford Field (Detroit)
- TV: FOX
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