NFL Betting Trends That Matter: Week 2 Moneyline, Spread & O/U Notes

The latest NFL betting trends help to point us in the right direction when deciding which Week 1 wagers to place.

Despite 12 out of 16 games on opening weekend going Under, my NFL picks for Week 2's biggest games only predict one game going Under. Instead, I look to some of the league's top contenders to cover the spread in their respective games.

Our NFL predictions for Week 2 take a more in-depth dive into the Week 2 slate, including prime-time clashes between bitter coaching rivals in Chargers vs. Raiders.

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🏈 Commanders vs. Packers preview

📈 Commanders vs. Packers betting trends

• Green Bay leads the all-time series 22-17-1 over Washington
• The Commanders have won three of the last five matchups dating back to 2016
• Washington is 5-5 ATS in the last 10 meetings with the Packers
• Jayden Daniels is 13-7-1 ATS as a starter; Jordan Love is 21-17 ATS in the same role
• These NFC teams have combined to go 5-5 to the total in their last 10

📊 Commanders vs. Packers odds

🔮 Commanders vs. Packers prediction

Can the Commanders continue to grow in year two under Daniels, or will Washington regress in the starting signal caller's second season under center? That's the question that remains unanswered among pundits. A lackluster victory over the lowly New York Giants hardly eases critics' concerns early on.

While I was tempted to play the total in this Commanders vs. Packers contest - seeing as the Under has hit in three of the teams' last five meetings - I believe 48 is a tricky number. As such, I've opted to fade the visitors in favor of a team that looked dominant in every facet during an opening week win over Detroit.

Jordan Love has been a bettor's dream since taking over for Aaron Rodgers. The Green Bay gunslinger has posted an 11-7 ATS record in two-plus seasons as the starter at Lambeau Field, one of the league's best tallies. Compare that to Daniels, whose Washington team was a mediocre 3-4-1 ATS away from home last regular season. 

Our Gary Pearson dives deeper with his Commanders vs. Packers prediction.

✅ Best bet: Packers -3.5 (-105 via FanDuel) ⭐️⭐️⭐️⭐️

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🏈 Eagles vs. Chiefs preview

📈 Eagles vs. Chiefs betting trends

• Kansas City and Philadelphia have split their series at six wins apiece, with the latter winning the last two
• Jalen Hurts and Patrick Mahomes are 2-2 SU in head-to-head meetings
• The Eagles have covered at a 60% clip in its last 10 versus the Chiefs
• The Under is 6-4 in Kansas City and Philadelphia's past 10 matchups
• Mahomes is 22-5 coming off a loss in his career (regular season and postseason)

📊 Eagles vs. Chiefs odds

🔮 Eagles vs. Chiefs prediction

Some of Mahomes' stats are superhuman. However, his career home record of 58-13 (81.69% win percentage) might be the most impressive. The future Hall of Fame quarterback is also 22-5 immediately following a loss in his eight seasons as Kansas City's starter.

All of this is to say defeat is not an option for the Chiefs in this spot.

The reigning AFC champions cannot afford to fall into a 0-2 hole and risk falling two games behind in a vastly improved division. Philadelphia earned a statement win over Dallas in Week 1, but the Eagles didn't look nearly as dominant as last season.

Revenge will be on the mind of the hosts, so I'll take a flier on Mahomes and Co. at plus-money in front of a raucous crowd at Arrowhead Stadium.

✅ Best bet: Chiefs moneyline (+105 via DraftKings) ⭐️⭐️⭐️

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🏈 Falcons vs. Vikings preview

📈 Falcons vs. Vikings betting trends

• Minnesota leads the all-time series over Atlanta, 22-12, including six of the last seven straight up
• Kevin O'Connell is 26-23-5 ATS with the Vikings; Raheem Morris is 6-11-1 ATS with the Falcons
• O'Connell is 1-0 SU and ATS against Morris, winning 42-21 as a 6-point favorite in 2024
• Atlanta and Minnesota have combined to go Over in their last three head-to-head meetings
• The Falcons and Vikings were two of the NFL's best Under teams last season, going Under at a 60% clip

📊 Falcons vs. Vikings odds

🔮 Falcons vs. Vikings prediction

This Falcons vs. Vikings matchup is one of the more intriguing games on the docket, as it features two future faces of the league in Atlanta's Michael Penix Jr. and Minnesota's J.J. McCarthy. Both young quarterbacks were impressive in Week 1, but the teams picked up different results. 

Ultimately, results come down to coaching. Kevin O'Connell proved himself as one of the league's brightest offensive minds last season when guiding Minnesota to a 14-3 record, including a 42-21 thrashing of Atlanta. Meanwhile, there's a reason Raheem Morris is among the NFL first coach to be fired odds favorites.

I'm going to go against my better judgment, and zig where others are zagging with advice from the zig-zag trend ... are you still following? Pardon my contrived train of thought, it's all a roundabout way of stating that I'll cautiously fade the Falcons, despite what the trends tell us.

✅ Best bet: Vikings -4.5 (-110 via BetMGM) ⭐️⭐️⭐️

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🏈 Buccaneers vs. Texans preview

📈 Buccaneers vs. Texans betting trends

• Historically, Houston has dominated Tampa Bay, posting a 5-1 SU record
• The Texans have beaten the Buccaneers in five straight head-to-head meetings since 2007
• Tampa Bay is 0-3 SU against Houston at NRG Stadium, but 1-2 ATS, with the lone cover coming last year
• Todd Bowles is 27-28-1 ATS with the Buccaneers; DeMeco Ryans is 19-18-2 ATS with the Texans
• The Buccaneers boasted a 12-6 record to the Over in 2024, whereas the Texans went Under in 63.16% of games last season

📊 Buccaneers vs. Texans odds

🔮 Buccaneers vs. Texans prediction

Week 2's Monday Night Football doubleheader kicks off with an exciting Buccaneers vs. Texans matchup from the Lone Star State. Both teams demanded attention on opening weekend with their close contests, so how should bettors play this prime-time bout?

I think Houston has the potential to be an Under bettor's cash cow this campaign. The Texans are still trying to iron out the kinks on offense, but they boast a stellar defense that keeps them in nearly every game.

Houston has already hit the Under at a 63.2% clip since Ryans' appointment. The Texans' 24-14-1 record to the Under is the second-best in the NFL during that span, only trailing the New York Giants (23-12). Tampa Bay is 31-25 to the Under since Bowles was hired, so the writing is seemingly on the wall for this showdown.

✅ Best bet: Under 42.5 (-110 via FanDuel) ⭐️⭐️⭐️⭐️

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🏈 Chargers vs. Raiders preview

📈 Chargers vs. Raiders betting trends

• Las Vegas leads the all-time series, 69-60-2, over Los Angeles
• Pete Carroll and Jim Harbaugh have split their 12 meetings in the NFL and NCAA at six apiece
• Carroll has won five of the last six head-to-head against Harbaugh
• The Chargers are 6-4 ATS over the Raiders across their last 10 divisional duels
• Last season saw Los Angeles cover in both games, with one going Under and the most recent, Over

📊 Chargers vs. Raiders odds

🔮 Chargers vs. Raiders prediction

There's something about Allegiant Stadium that brings out the best in both of these teams' offenses. The Over has hit in five of the Raiders' last six home games against the Chargers, including four of those wins since relocating to Las Vegas.

Meanwhile, Los Angeles' last six games have all gone Over. Steady quarterback play provides this game with a solid foundation for a lot of scoring, so I'll lean Over 47 points. This play is trading at standard juice with the best shops, meaning a $10 winning wager proftis $9.09.

✅ Best bet: Over 47 (-110 via Caesars) ⭐️⭐️⭐️

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❓ NFL trends FAQs

What are the best NFL trends for Week 2?

My best NFL trends for Week 2 expect the Green Bay to cover a 3.5-point spread vs. Washington, adding to Jordan Love's 11-7 ATS record at home. I also like Houston to build upon its 63.2% Under percentage with DeMeco Ryans at the helm, going Under 42.5 against Tampa Bay.

How do NFL odds work?

When betting on NFL odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.

You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.

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