Monday Night Football Odds & Predictions Week 6: Bills, Commanders Favorites for Doubleheader
The Monday Night Football odds for Week 6 have the Buffalo Bills and Washington Commanders as betting favorites against the Atlanta Falcons and Chicago Bears, respectively. The Week 6 MNF doubleheader will have games starting at 7:15 and 8:15 p.m. ET.
Our NFL picks will cover both games with picks against the spread, Over/Under, player props, parlay picks, and anytime touchdown scorer predictions as part of our NFL predictions for Week 6.
We're looking at both games with our Bills vs. Falcons prediction and Bears vs. Commanders prediction.
📊 MNF Week 6 odds: Bills (-3.5) vs. Falcons
The NFL odds for Week 6 swung in Atlanta's favor following the Bills' Sunday Night Football loss to the Patriots. The Falcons were on a bye and will stay at home for Monday Night Football. Bills bettors can get a line of -3.5 at Caesars, while Falcons backers should head to DraftKings for the better line of +4.5.
The Over/Under is a consensus of 48.5, but FanDuel has the best odds (-105) for the Under.
Live Bills vs. Falcons odds
Our NFL odds update in real time and show the best line/odds for either side of the spread, Over/Under, and moneyline:
📊 MNF Week 6 odds: Bears vs. Commanders (-4.5)
The Commanders are favored on a consensus betting line of 4.5 points after upsetting the Los Angeles Chargers on the road last week. QB Jayden Daniels returned from injury to pass for 231 yards and a touchdown, with another 39 rushing yards.
The Bears, meanwhile, have won two straight and are 1-1 on the road this season.
Live Bears vs. Commanders odds
🔮 Monday Night Football predictions
Here are our betting experts' NFL picks for the Monday Night Football contests between the Bills and Falcons, and Bears and Commanders:
Bills vs. Falcons predictions:
ATL (+189) via Mike Spector: "In the Falcons’ last game action prior to last week’s bye, quarterback Michael Penix Jr. turned in his second career game with 300 passing yards, while running back Bijan Robinson totaled a career-high 181 scrimmage yards.
Buffalo has been one of the league’s worst run defenses all season, but now can add to its list of concerns after allowing 61 yards after the catch to Stefon Diggs, his most in a game since 2022 when Josh Allen was throwing him passes."
BUF -4.5 (-110) via Phil Wood: "If the Bills can slow down Bijan Robinson, the Falcons won't be able to keep pace with a Buffalo offense scoring over 30 per game."
BUF -4.5 (-110) via C Jackson Cowart: "The Bills rarely lose two games in a row, and I suspect Josh Allen will have a field day against a Falcons defense that needs pressure to survive on the back end. Unless Michael Penix Jr. plays the game of his life, this will be a tough game for Atlanta to win."
Bears vs. Commanders predictions:
u50.5 (-115) via Isaiah Sirois: "While Chicago is off to a hot start and is 3-1 to the Over, this is the highest total posted for the Bears all season. It’s time to sell high on the Bears against the Commanders’ sturdy defensive line, which ranks third in run-stop win rate and 13th in pass-rush win rate."
WAS -4.0 (-110) via C Jackson Cowart: "It's hard to know what to expect from the Commanders given how little we've seen them at full strength. I was impressed by last week's win over the Chargers, though, and I'm skeptical of the Bears in a tough road spot against a legitimate contender."
📜 Monday Night Football betting results
Here are the results of the spread and Over/Under from every completed Monday Night Football game this season:
| Week | Matchup | Spread | Over/Under |
|---|---|---|---|
| 1 | Vikings vs. Bears | Vikings +1.5 | O43.5 |
| 2 | Buccaneers vs. Texas | Buccaneers +2.5 | U42.5 |
| 2 | Chargers vs. Raiders | Chargers -3.5 | U46.5 |
| 3 | Lions vs. Ravens | Lions +4.5 | O53.5 |
| 4 | Jets vs. Dolphins | Dolphins -2.5 | O43.5 |
| 4 | Bengals vs. Broncos | Broncos -7.5 | U44.5 |
| 5 | Chiefs vs. Jaguars | Jaguars +3.5 | O45.5 |
🗓️ Monday Night Football 2025 schedule
Opening Monday Night Football NFL odds for the 2025 season regular season are via DraftKings.
| Week | Matcup | Opening spread | Opening Over/Under |
|---|---|---|---|
| 6 (Oct. 13) | Bills vs. Falcons | Bills -5.5 | 48.5 |
| 6 (Oct. 13) | Bears vs. Commanders | Commanders -4.5 | 48.5 |
| 7 (Oct. 20) | Buccaneers vs. Lions | Lions -3.5 | 49.5 |
| 7 (Oct. 20) | Texans vs. Seahawks | Seahawks -1.5 | 44.5 |
| 8 (Oct. 27) | Commanders vs. Chiefs | Chiefs -3.5 | 48.5 |
| 9 (Nov. 3) | Cardinals vs. Cowboys | Cowboys -1.5 | 47.5 |
| 10 (Nov. 10) | Eagles vs. Packers | Eagles -1.5 | 45.5 |
| 11 (Nov. 17) | Cowboys vs. Raiders | Cowboys -1.5 | 45.5 |
| 12 (Nov. 24) | Panthers vs. 49ers | 49ers -7 | 46.5 |
| 13 (Dec. 1) | Giants vs. Patriots | Patriots -3 | 42.5 |
| 14 (Dec. 8) | Eagles vs. Chargers | Eagles -2.5 | 45.5 |
| 15 (Dec. 15) | Dolphins vs. Steelers | Steelers -2.5 | 44.5 |
| 16 (Dec. 22) | 49ers vs. Colts | 49ers -3 | 46.5 |
| 17 (Dec. 29) | Rams vs. Falcons | Rams -3 | 46.5 |
Don't miss our lists of the best NFL parlay betting sites and top NFL prop betting sites!
🧠 Monday Night Football betting tips
Get an early start
The Monday Night Football game is a big deal for betting each week. This brings lots of bets and changes in the odds, especially from those chasing their losses after a tough Sunday betting slate. Watch the lines and totals when they start. If they go the way you like, you can wait. If they move against you, think about acting sooner.
Embrace in-game betting
While you might struggle to find value in the most popular markets for any marquee prime-time NFL game, you're sure to unearth some worthwhile plays once the game starts. Live betting might not be your thing when there are a handful of games going on at the same time, but Monday Night Football is the perfect time to lay into some live action via our best live betting sites.
Be wary of winter weather
Things can get pretty frightful outside later in the NFL season – particularly when the sun goes down. Our guide on how to bet on the NFL offers tips for how to approach betting on cold-weather games.
Check out our list of the best sportsbook promos here!
❓Monday Night Football FAQs
Who is favored on Monday Night Football this week?
The Buffalo Bills and Washington Commanders are favorites by the Monday Night Football odds for Week 6 against then Atlanta Falcons and Chicago Bears, respectively.
How do I watch Sunday Night Football?
Monday Night Football is broadcast on ESPN with some doubleheaders appearing on ABC.
Who are the announcers on Monday Night Football?
Joe Buck and Troy Aikman are the current commentators for Monday Night Football on ESPN. Laura Rutledge and Lisa Salters are the sideline reporters, and Russell Yurk is the rules analyst on the broadcast.
Who will make the most Monday Night Football appearances in 2025?
No team will make more than two appearances on Monday Night Football season.
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