Monday Night Football Odds & Predictions Week 16: 49ers vs. Colts MNF Betting Lines
Philip Rivers will make his second start of the season, and first on prime time, when his Indianapolis Colts (8-6) host the San Francisco 49ers (10-4) at Lucas Oil Stadium in Indianapolis for the weekly 8:15 p.m. ET kickoff on ESPN. The 49ers are the 5.5-point betting favorite, according to the Monday Night Football odds for Week 16.
We'll break down this game all week as part of our NFL Week 16 predictions.
๐ MNF Week 16 odds: 49ers (-5.5) vs. Colts
The NFL odds for Week 16 have stayed rather flat, even after the Colts played a much more competitive than what was expected in Rivers' first start last week. Indianapolis lost on a last-second field goal to the Seattle Seahawks as a 13.5-point underdog on the road. Rivers is bound to have plenty of support at home with the Colts still fighting for a playoff spot.
Yet, our Corey Scott backs San Francisco to cover with a convincing win as his early 49ers vs. Colts prediction.
Live Monday Night Football odds
Our NFL odds update in real time and show the best line/odds for either side of the spread, Over/Under, and moneyline:
๐ฎ Monday Night Football predictions Week 16
Here are our expert Monday Night Football predictions for 49ers vs, Colts, as part of our NFL picks:
SF -5.5 (-105) via Corey Scott: "This line's too low, suggesting the 49ers would only be 3-point favorites if this were in Santa Clara. They've covered in four straight, winning by 15.3 points per game."
๐ Monday Night Football betting results
Here are the results of the spread and Over/Under from every completed Monday Night Football game this season:
| Week | Matchup | Spread | Over/Under |
|---|---|---|---|
| 1 | Vikings vs. Bears | Vikings +1.5 | O43.5 |
| 2 | Buccaneers vs. Texas | Buccaneers +2.5 | U42.5 |
| 2 | Chargers vs. Raiders | Chargers -3.5 | U46.5 |
| 3 | Lions vs. Ravens | Lions +4.5 | O53.5 |
| 4 | Jets vs. Dolphins | Dolphins -2.5 | O43.5 |
| 4 | Bengals vs. Broncos | Broncos -7.5 | U44.5 |
| 5 | Chiefs vs. Jaguars | Jaguars +3.5 | O45.5 |
| 6 | Bills vs. Falcons | Falcons +3.5 | U49.5 |
| 7 | Buccaneers vs. Lions | Lions -6.5 | U54.5 |
| 7 | Texans vs. Seahawks | Seahawks -3.5 | O41.5 |
| 8 | Commanders vs. Chiefs | Chiefs -11.5 | U48.5 |
| 9 | Cardinals vs. Cowboys | Cardinals +3.5 | U53.5 |
| 10 | Eagles vs. Packers | Eagles +1.5 | U44.5 |
| 11 | Cowboys vs. Raiders | Cowboys -3.5 | O48.5 |
| 12 | Panthers vs. 49ers | 49ers -7.5 | U49.5 |
| 13 | Giants vs. Patriots | Patriots -7 | O46.5 |
| 14 | Eagles vs. Chargers | Chargers +1.5 | U42.5 |
| 15 | Dolphins vs. Steelers | Steelers -3.5 | U43.5 |
๐๏ธ Monday Night Football 2025 schedule
Opening Monday Night Football NFL odds for the 2025 season regular season are via DraftKings.
| Week | Matcup | Opening spread | Opening Over/Under |
|---|---|---|---|
| 16 (Dec. 22) | 49ers vs. Colts | 49ers -3 | 46.5 |
| 17 (Dec. 29) | Rams vs. Falcons | Rams -3 | 46.5 |
Don't miss our lists of the best NFL parlay betting sites and top NFL prop betting sites!
โMonday Night Football FAQs
Who is favored on Monday Night Football this week?
The San Francisco 49ers are the 5.5-point betting favorite on the road against the Indianapolis Colts, according to the Monday Night Football odds for Week 16.
How do I watch Monday Night Football?
Monday Night Football is broadcast on ESPN with some doubleheaders appearing on ABC.
Who are the announcers on Monday Night Football?
Joe Buck and Troy Aikman are the current commentators for Monday Night Football on ESPN. Laura Rutledge and Lisa Salters are the sideline reporters, and Russell Yurk is the rules analyst on the broadcast.
Who will make the most Monday Night Football appearances in 2025?
No team will make more than two appearances on Monday Night Football season.
📃 Affiliate disclosure
Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
Related Articles
