NFL Expert Picks & Staff Predictions Today: Week 4 Best Bets and Player Props This Week

Last Updated: September 28, 2025 6:00 AM EDT • 5 minute read X Social Google News Link

Get set for Week 4 with us and our NFL expert picks and staff predictions. We're covering five games from this afternoon's slate as a team, featuring NFL picks on the Saints vs. Bills, Browns vs. Lions, Eagles vs. Buccaneers, Colts vs. Rams, and Ravens vs. Chiefs, with kickoffs beginning at 1 p.m. ET.
Read on for our comprehensive NFL predictions.
NFL Week 4 expert picks
NFL picks made by Dustin Saracini, Gary Pearson, LJ Blut, and Sean Tomlinson based on the best NFL odds for Week 4.
Game | Dustin Saracini | LJ Blut | Gary Pearson | Sean Tomlinson |
---|---|---|---|---|
Saints vs. Bills | Bills -15.5 (-118 via FanDuel) | Bills -15.5 (-118 via FanDuel) | Over 48 (-113 via Caears) | Over 48 (-113 via Caesars) |
Browns vs. Lions | Browns +10.5 (-110 via FanDuel) | Browns +10.5 (-110 via FanDuel) | Over 44.5 (-105 BetMGM) | Under 44.5 (-111 via bet365) |
Eagles vs. Buccaneers | Buccaneers +3.5 (-108 via DraftKings) | Buccaneers +3.5 (-108 via DraftKings) | Eagles -3.5 (-110 via Caesars) | Buccaneers +3.5 (-110 via Caesars) |
Colts vs. Rams | Rams -3.5 (-105 via BetMGM) | Colts +3.5 (-105 via DraftKings) | Rams -3.5 (-105 via BetMGM) | Colts +3.5 (-105 via DraftKings) |
Ravens vs. Chiefs | Ravens -2.5 (-115 via Caesars) | Ravens -2.5 (-115 via Caesars) | Ravens -2.5 (-115 via Caesars) | Over 48.5 (-110 via Caesars) |
This weekend features a handful of intriguing matchups, starting with the Browns vs. Lions, and ending with an AFC showdown between the Ravens vs. Chiefs.
Whether you're looking for Week 4 moneyline picks or Week 4 against the spread predictions, we have you covered. But first, let's cash with the SBR staff.
Expert NFL game picks | SBR staff record (7-1)

Dustin Saracini: Ravens -2.5 vs Chiefs (-118)
The Baltimore Ravens are coming off an excruciating loss to the Detroit Lions, and Kansas City just isn’t the same Chiefs team we’ve come accustomed to watching.
The Chiefs are a one-dimensional offense right now. The running game hasn't been able to get going through three weeks, with Kansas City entering Week 4 with the 17th-ranked rushing unit. You can’t keep up with the Ravens that way.
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Gary Pearson: Rams -3.5 vs. Colts (-110)
I’m still having trouble comprehending the Los Angeles Rams’ wholesale implosion in Philly against the defending champs. That shock defeat, however, should inject further motivation into Sean McVay’s team.
I also believe the NFL’s surprise act thus far, the Indianapolis Colts, are due for a loss. The Rams have the fifth-best offensive DVOA, markedly better than the Denver Broncos’ 18th, the best of the Colts' previous three opponents.
Sean Tomlinson: Bills-Saints Over 48 (-113)
It’s hard to find two teams on more opposing ends of the NFL talent spectrum. But an inept Saints offense that sits 29th in points per game (15.7) won’t need to do much lifting to cash this Over. In fact, getting at or around that average would be just fine, thanks, and that’s exactly how the Saints’ 44-13 Week 3 drubbing at the hands of the Seattle Seahawks played out.
For their part, the Bills have scored 30–plus points in three straight games, with a high of 41 in Week 1.
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LJ Blut: Colts +3.5 vs. Rams (-105)
The Daniel Jones-led Colts have been the surprise story of the season. They are off to a 3-0 start and look to build off the early-season momentum.
The Colts are 3-0 ATS as well this season, and are one of only a handful of teams to remain perfect. Getting the key number of 3.5 is important here as well, as I anticipate this game to finish with either team winning by 3 or less.
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Best NFL player prop bets | SBR staff record (5-3)
Saracini: Jahmyr Gibbs Under 64.5 rushing yards (-118)

Jahmyr Gibbs is undeniably one of the league’s most explosive running backs, but this week presents his toughest challenge yet against the Browns’ elite run defense.
Cleveland is allowing only 57.3 rushing yards per game, the fewest in the NFL. With Gibbs splitting touches alongside David Montgomery, the workload may not be there for him to go over this number.
Pearson: Baker Mayfield Over 17.5 rushing yards (-117)
I'm backing Baker Mayfield to scamper for at least 18 yards against the Eagles. Mayfield, one of the NFL’s most clutch QBs in the current campaign, has scrambled effectively through three games.
Mayfield rushed for at least 33 yards in all three games and six of the last seven dating back to last season. And he’s facing an Eagles team with the sixth-worst defensive DVOA against the run.
Tomlinson: Isiah Pacheco Over 34.5 rushing yards (-114)
Yes, Pacheco has been struggling so far while averaging just 30.7 rushing yards per game. But he gets an ideal breakout spot against a Baltimore Ravens run defense that’s been repeatedly getting gashed on the ground to the tune of 149.0 yards per contest (30th).
This is a low bar to meet, considering that weakness from Baltimore, even with Pacheco sharing some of the backfield work with Kareem Hunt. The game script should be favorable or neutral at worst, too, with our best sports betting apps giving this one a spread of -2.5 for Baltimore.
Blut: Josh Allen 2+ touchdowns (+330)
This Saints' defense has struggled mightily all season, especially against the run. The Bills, conversely, are one of the best rushing teams in the NFL.
Josh Allen should have plenty of opportunities by the goal line to run a few in, with the books projecting this total close to 50 points. We should see the Bills put up a high score, and I am taking a long-shot play on Mr. Allen to find pay dirt twice.
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