Rams vs. Jaguars Prediction & Odds: International Series Opening Odds & Picks

Last Updated: October 13, 2025 7:23 AM EDT • 2 minute read X Social Google News Link

The last of three games in London sees the Jacksonville Jaguars face the Los Angeles Rams at Wembley Stadium on Sunday (9:30 a.m. ET, NFL Network), as I offer my Rams vs. Jaguars prediction.
These NFL picks, part of our NFL predictions for Week 7, back the 3-point betting underdog Jaguars, thanks to a couple of key reasons.
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🏈 Rams vs. Jaguars prediction & best bet
Stay ahead with the rest of our early NFL predictions for Week 7.
Jaguars +3 (-102) ⭐⭐⭐
There are a couple of decisive factors in backing the Jaguars to cover as the 3-point betting underdog, the most important of which revolves around Rams wide receiver Puka Nacua's ankle injury.
Rams head coach Sean McVay said after their win against the Baltimore Ravens that the NFL's leader in receiving yards entering Week 6 might not win the race against time.
I don't expect Nacua to play, as unless their star receiver is 100% healthy, they will err on the side of caution. Nacua, who was on an NFL record-breaking pace before the injury, accounted for 39% of Matthew Stafford's passing yards through the first six games.
While Davante Adams would step into Nacua's No. 1 role seamlessly, the drop-off in productivity and ability thereafter is disconcerting.
Tutu Atwell, the team's third-most productive receiver entering Week 6, missed the Ravens game due to a minor hamstring pull. He'll probably return, but will there be any residual rust, and will he feature in as many snaps as usual?
Otherwise, the Jaguars should find more joy on the ground in a better matchup than against Seattle. Before facing the Seahawks, the Jaguars had the sixth-best offensive rushing DVOA. Compare that to the Rams' middling 15th-ranked defensive rushing DVOA before they faced the Ravens in Baltimore, where they were gashed for 179 yards.
The odds at the best sports betting sites range from -102 at DraftKings to -115 at FanDuel, with a winning $10 bet at the former paying a profit of $9.80, compared to $8.79 at the latter.
📊 Rams vs. Jaguars odds: International Series
Latest NFL odds updated live in real time.
📈 Rams vs. Jaguars opening odds
- Moneyline: Rams -180 | Jaguars +150
- Spread: Rams -3.5 (-110) | Jaguars +3.5 (-110)
- Over/Under: Over 46.5 (-110) | Under 46.5 (-110)
💡 Rams vs. Jaguars odds analysis
The betting line will likely decrease to +2.5, maybe even +2, if Nacua is ruled out. My recommendation is to lock in the wager before that potential outcome occurs. Even if he plays, I don't see the Rams' line increasing beyond -3.5.
📺 How to watch NFL International Series
- Matchup: Rams vs. Jaguars
- When: Sunday, Oct. 19 @ 9:30 a.m. ET
- Where: Wembley Stadium (London)
- TV: NFL Network
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Gary Pearson X social