Early Chiefs vs. Giants Prediction, Odds & Picks for SNF: NFL Week 3

My early Chiefs vs. Giants prediction for Week 3's Sunday Night Football tilt expects the Chiefs to get their first win and cover the spread.

Philip Wood

Last Updated: September 15, 2025 7:56 AM EDT • 4 minute read

Early Chiefs vs. Giants Prediction, Odds & Picks for SNF: NFL Week 3 — Pictured: New York Giants wide receiver Malik Nabers (1) reacts after scoring a touchdown. Photo by Raymond Carlin III-Imagn Images

I make my best early Chiefs vs. Giants prediction, as the two 0-2 teams meet in Week 3 on Sunday Night Football at 8:20 p.m. ET (NBC) at MetLife Stadium in East Rutherford, N.J. The Chiefs are the 5.5-point betting favorite, and I expect them to be one of the most popular NFL picks this week.

Giants quarterback Russell Wilson led his squad to 37 points in an overtime loss against the Dallas Cowboys last week, but can they decipher a defense that held the Philadelphia Eagles to 20 points? Read on for more about this game and the best NFL predictions for Week 3.

💰 Early Chiefs vs. Giants prediction & best bet

Stay ahead with the rest of our early NFL predictions.

🔴 Chiefs -5.5 (-110) ⭐⭐⭐⭐⭐

Russell Wilson put up 450 passing yards in Week 2, but the Giants’ defense gave up 478 total yards and 32 first downs. Considering the Giants scored just six points in Week 1, while allowing 432 yards to the Washington Commanders, I’m betting the Giants’ offensive performance was a fluke, but that the defense will be awful all season.

The Chiefs held the Eagles to just 216 yards, yet they still lost the game. The Chiefs' defense should have no trouble keeping the Giants’ one-dimensional offense in check, while Mahomes dissects a defense that hasn’t been able to stop Jayden Daniels or Dak Prescott.

A majority (66%) of bettors are backing the Chiefs to cover, which has already shifted the spread a half-point at multiple sportsbooks. The price of -110 for -5.5 at Caesars implies a 52.38% chance the Chiefs cover. A $10 bet would pay $9.09

📊 Chiefs vs. Giants odds: Week 3

NFL odds update live in real time.

📈 Chiefs vs. Giants opening odds

Moneyline: Chiefs -275 | Giants +225
Spread: Chiefs -5.5 (-110) | Giants +5.5 (-110)
Over/Under: Over 42.5 (-110) | Under 42.5 (-110)

🔍 Chiefs vs. Giants odds analysis

I expect the Chiefs to get all the public support in the build-up to this game. Despite starting 0-2, nearly two-thirds of the public is backing them to cover in early betting, and I wouldn’t be surprised if this number gets to 7.5 before the middle of the week. I’d take the Chiefs to cover up to 10, so even if you don’t get in right away, the Chiefs will be the right play all week.

As for the total, I expect the number to increase because of the 40-37 loss the Giants suffered in Week 2. However, the Chiefs' defense looked great against the Eagles, and I wouldn’t be surprised if they hold the Giants to 14 or fewer points. Therefore, I recommend playing the Under. You can probably wait a bit to get in at a higher number than the 42.5 currently available.

🚑 Chiefs vs. Giants injury report

📺 Chiefs vs. Giants game info

When: Sunday, Sept. 21
Kickoff: 8:20 p.m. ET
Where: MetLife Stadium (East Rutherford, N.J.)
How to watch: NBC

❓ Chiefs vs. Giants FAQs

Who is favored to win Chiefs vs. Giants?

The Chiefs are favored with the best moneyline available set at -250 at bet365 and DraftKings. The price implies a 71.43% chance the Chiefs win. BetMGM has the best moneyline odds available for the Giants, with the price of +225 suggesting the Giants have a 30.77% chance to win.

What are the opening odds for Chiefs vs. Giants?

The Chiefs opened as 5.5-point favorites. The total opened at 42.5 points.

How do NFL odds work?

When betting on NFL odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.

Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.

You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.

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Written by:
Philip Wood

Phil has covered sports betting since 2016 and has been sharing his NFL experience with SportsBook Review since 2022. He previously hosted the College Football Pick 'Em podcast for CanesInsight.com. He is always looking for value, especially on lines that just seem too good to be true. His belief is that if a line doesn't make sense just assume oddsmakers know something you don't. He also loves in-season futures. There is so much value to be had as the public overreacts weekly. Bettors tend to forget just how long NFL and college football seasons are. After all, the Green Bay Packers were 2-5 in 2023 and they made it to the Divisional Round. When deciding where to bet, it comes down to value over everything. +100 is always better than -110. An alumnus of The U, Phil always holds out hope that the next head coach will be the one who turns the football program around. He is also a diehard Detroit Lions fan and is willing to forgive Dan Campbell for forgetting that a kicker can be useful.