Early Chargers vs. Raiders Prediction, Odds & Picks for MNF: NFL Week 2

My early Chargers vs. Raiders prediction expects the visitors to cover the spread and continue to roll like they did in their opener.

Gary Pearson

Last Updated: September 8, 2025 9:54 AM EDT • 4 minute read

Early Chargers vs. Raiders Prediction, Odds & Picks for MNF: NFL Week 2 — Pictured: Justin Herbert scampers free against the Kansas City Chiefs. Photo by Paulo De Tarso via Imagn Images

The Los Angeles Chargers travel to Allegiant Stadium to face the Las Vegas Raiders for Monday Night Football, with both teams sporting a 1-0 record.

My Chargers vs. Raiders prediction expects the visitors to not only continue where they left off last season on the road, but also to extend their impressive form from the Week 1 win over the Kansas City Chiefs.

The Chargers are the 3 betting favorite, and the below NFL picks are part of our NFL predictions for Week 2. Monday's game starts at 10 p.m. ET (ESPN).

💰 Early Chargers vs. Raiders prediction & best bet

Stay ahead with the rest of our early NFL predictions.

Chargers -3 (-115) ⭐⭐⭐⭐

Justin Herbert is one of the best regular-season quarterbacks, period. He was also tied with Jalen Hurts for the 10th-most clutch QB last season.

Herbert displayed why against one of last season's better pass defenses (eighth in pressure and fifth in coverage, via PFF), carving up the Kansas City Chiefs to the tune of 304 yards and three TDs.

He showed his mobility, too, and made excellent decisions with the ball, running for 32 yards on seven carries, one of which ended the Chiefs' comeback bid.

All from the team that is supposed to employ a run-heavy offense. I was impressed with offensive coordinator Greg Roman's play calling as he kept the Chiefs defense off-balance, giving them a high dosage of what appears to be a significantly improved pass attack.

Meanwhile, the Raiders' defense looked better than the sum of its parts against the New England Patriots' offense, which struggled to establish a ground game. The Chargers shouldn't have those same issues with Herbert, Omarion Hampton (who had 48 rushing yards in his debut), and to a much lesser extent, Najee Harris, providing a three-pronged attack.

Additionally, the Chargers were 7-2 ATS on the road last season, 6-1 ATS as the betting favorite on enemy territory, and 2-0 ATS against the Raiders. Admittedly, this Raiders team is substantially better than last season's. Still, the Chargers appear ready to take the next step, and they should bring the Raiders back down to earth in Week 2.

📊 Chargers vs. Raiders odds: Week 2

NFL odds update live in real time.

📈 Chargers vs. Raiders opening odds

Moneyline: Chargers -155 | Raiders +130
Spread: Chargers -3 (-105) | Raiders +3 (-115)
Over/Under: Over 44.5 (-110) | Under 44.5 (-110)

🔍 Chargers vs. Raiders odds analysis

The Chargers are favored by either 3 or 3.5 points. Of the best sports betting sites, FanDuel offers the best value for -3 (-115), while BetMGM has them at -3.5 for standard -110 odds. Early money is coming in on the Chargers, with 72% of bets backing them to cover. That will likely see the spread hop to -3.5 at all of the best sports betting apps, so get in on the -3 while you still can.

🚑 Chargers vs. Raiders injury report

📺 Chargers vs. Raiders game info

When: Monday, Sept. 15
Kickoff: 10 p.m. ET
Where: Allegiant Stadium (Las Vegas)
How to watch: ESPN

❓ Chargers vs. Raiders FAQs

Who is favored to win Chargers vs. Raiders?

The Chargers are the betting favorite, with odds ranging from -168 to -190. The Raiders' underdog odds range from +142 to +158.

What are the opening odds for Chargers vs. Raiders?

The Chargers are the 3-point betting favorite at FanDuel, where you can find odds of -115. You can find +100 odds for the +3 Raiders at DraftKings.

How do NFL odds work?

When betting on NFL odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.

Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.

You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.

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Written by:
Gary Pearson

Gary Pearson has written professionally since 2010, focusing on sports betting since 2014. Before entering the sports betting space, he contributed to the Canadian Press, FanSided, the Hockey Writers, the Calgary Herald, and other publications. His work and NFL experience has also been featured in Sports Illustrated and Bleacher Report. Gary, who consumes sports like a blue whale devours plankton, has a penchant for writing predictions and analyses across several sports, including hockey, soccer, football, tennis, and more. He bets regularly, preferring single-game picks, props, and live betting. While there isn't a sport he has yet to dabble in, Gary prefers betting on soccer, hockey, and football. He studied at various post-secondary institutions, including the University of Calgary, SAIT Polytechnic, and Griffith University, located in Brisbane, Australia. Gary has a marketing degree and completed his bachelor's degree in journalism at Griffith University. He feels strongly that life experience is as essential as post-secondary education, helping formulate more accurate predictions and analyses. Gary believes that competing at a high level of amateur sports during his formative years helped him better understand an athlete's psyche and the nuances and complexities of a team's dynamic, both on and off the playing surface. He feels that knowledge is immeasurably important when offering his analytical expertise. He has lived on five continents and currently resides in Canada.