Buccaneers vs. Lions Prediction & Odds: Monday Night Football Opening Odds & Picks

Last Updated: October 13, 2025 2:59 PM EDT • 2 minute read X Social Google News Link

My best Buccaneers vs. Lions prediction based on the opening odds and early picks for the 7 p.m. ET (ABC/ESPN) Monday Night Football game at Ford Field in Detroit, focuses on the key injuries both teams are dealing with. The Lions are 5.5-point home favorites over the 5-1 Buccaneers.
Baker Mayfield will do his best to keep pace with the Lions’ offense, despite missing numerous key offensive weapons. Read on for NFL picks regarding this game, and for more about the upcoming slate of contests, check out our NFL predictions for Week 7.
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🏈 Buccaneers vs. Lions prediction & best bet
Stay ahead with the rest of our early NFL predictions for Week 7.
🦁 Lions -5.5 (-105) ⭐⭐⭐⭐
The Lions’ secondary is depleted, but the Buccaneers' receiving corps is even worse off. Chris Godwin’s status for Week 7 is up in the air, Emeka Egbuka is expected to miss a few weeks, according to NFL Network’s Ian Rapoport, and we still don’t know when Mike Evans will return. Then there is running back Bucky Irving, who has already missed multiple games and early reports indicate he will miss another Monday.
The Lions scored only 17 points on Sunday night, yet they still have the second-highest scoring offense in football. With the Buccaneers allowing 25.2 points per game, I don’t see how Baker Mayfield keeps up with Jared Goff and Co. with so many weapons missing or potentially playing banged up.
The price of -105 from FanDuel implies a 51.22% chance the Lions cover. A $10 bet would pay $9.52.
📊 Buccaneers vs. Lions odds: Monday Night Football
Latest NFL odds updated live in real time.
📈 Buccaneers vs. Lions opening odds
- Moneyline: Buccaneers +200 | Lions -250
- Spread: +5.5 (-110) | Lions -5.5 (-110)
- Over/Under: Over 53.5 (-110) | Under 53.5 (-110)
💡 🔍 Buccaneers vs. Lions odds analysis
The Lions opened as 5.5-point favorites, and the public is slightly favoring them to cover. However, the movement of this spread will depend entirely on injury news throughout the week. If the Buccaneers get healthy, then I expect this number to drop to 3.5, especially if Lions’ safety Brian Branch gets suspended for his role in Sunday’s postgame fight.As for the total, the number is set at 53.5, and with 61% of public bettors backing the Over in a game between two top-6 scoring offenses, I expect this already high number to climb as high as 55.
📺️ How to watch Monday Night Football
- Matchup: Buccaneers vs. Lions
- When: Monday, Oct. 20 @ 7 p.m. ET
- Where: Ford Field (Detroit)
- TV: ABC/ESPN
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Philip Wood X social