Bengals vs. Broncos Prediction, Odds MNF: NFL Prime-Time Week 4 Best Bets
Last Updated: September 24, 2025 12:52 PM EDT • 4 minute read X Social Google News Link
The Cincinnati Bengals and Denver Broncos look to get back on track as they collide on Monday Night Football from Empower Field in Denver, and my Bengals vs. Broncos prediction is all over the Under.
The Broncos are the 7.5-point betting favorite (-105), and my NFL picks - part of the NFL predictions for Week 4 - expect both offenses to struggle.
Monday's game starts at 8:15 p.m. ET (ABC).
Bengals vs. Broncos prediction & best bet
Stay ahead with the rest of our early NFL predictions.
Under 45.5 (-110) ⭐⭐⭐⭐⭐
Neither of these offenses has lived up to lofty preseason expectations. Denver managed just nine first downs in last week’s 23-20 loss to the Los Angeles Chargers, and Bo Nix has yet to throw for more than 206 yards in his three outings. Meanwhile, the Bengals moved the chains only 12 times in Week 3 against the Minnesota Vikings, and their 262 total yards per game rank third-last in the NFL.
On the other side of the ball, Denver’s defense looks like its usual self, leading the league in sacks and third-down percentage. And while Cincy allowed 48 points last week, a lot of that damage was due to five turnovers by the offense - two of which were returned for touchdowns. It’s worth noting that the Bengals held Denver to 24 points and 19 first downs when these teams met last December.
With the Bengals looking to atone for last week’s humbling loss to Minnesota and the Broncos desperate to rebound from back-to-back losses, I’m expecting both defenses to lead the way on Monday Night Football. Most of the best sports betting sites had the total at 44.5 at the time of writing, so I was happy to grab Under 45.5 -110 at BetMGM. A winning $10 wager would profit $9.09 with an implied probability of 52.4%.
Bengals vs. Broncos odds: Week 4
NFL odds below update in real time:
Bengals vs. Broncos opening odds
- Moneyline: Bengals +280 | Broncos -350
- Spread: Bengals +7.5 (-110) | Broncos -7.5 (-110)
- Over/Under: Over 44.5 (-110) | Under 44.5 (-110)
Bengals vs. Broncos odds analysis
The Broncos were 6.5-point favorites on the lookahead lines, but re-opened as 7.5-point chalk after Cincinnati’s Week 3 blowout loss in Minnesota. Some of the best sports betting apps were shading their line slightly towards the Bengals, indicating the chance that we may see this line move down to 7 or fewer points as the week presses on.
Most shops opened the total at 44.5, and some 44s had already begun to appear at the time of writing.
Bengals vs. Broncos updated betting insights
- The Broncos opened as the 7.5-point betting favorite. That's where the line remains
- 66% of bets back the Broncos
- The total opened at 45.5 points. It has since decreased to between 43.5 and 44.5
More early NFL expert predictions
- Early Seahawks vs. Cardinals prediction
- Early Vikings vs. Steelers prediction
- Early Ravens vs. Chiefs prediction
- Early Packers vs. Cowboys prediction
- Early Jets vs. Dolphins prediction
- Early Bengals vs. Broncos prediction
Bengals vs. Broncos game info
- When: Monday, Sept. 29
- Kickoff: 8:15 p.m. ET
- Where: Empower Field at Mile High (Denver)
- How to watch: ABC
Bengals vs. Broncos FAQs
Who is favored to win Bengals vs. Broncos?
The Broncos are -350 favorites on the moneyline, which implies a 77.8% probability of a Denver victory. The Bengals pay +280 to pull off the outright upset, suggesting a 26.3% probability.
What are the opening odds for Bengals vs. Broncos?
The Broncos opened as 7.5-point home favorites, although some sites with the best sportsbook promos were charging slightly higher juice to back the underdog Bengals. The Over/Under was set at 44.5 at most sportsbooks.
How do NFL odds work?
When betting on NFL odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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Connor Cooper X social