Eagles vs. Packers Prediction & Opening Odds for Monday Night Football: NFL Week 10

My best early picks and Eagles vs. Packers prediction based on the opening odds for Monday Night Football focus on the Packers' inefficiency in the red zone. The Packers are favored by 2.5 points, but after an ugly loss to the Panthers, I’m doubting their ability to play with the defending Super Bowl champions this week. Kickoff is at 8:15 p.m. ET from Lambeau Field in Green Bay, Wis. (ABC/ESPN).

For more coverage of this game and all of next weekend’s action, check out our NFL Week 10 predictions.

🏈 Early Eagles vs. Packers prediction & betting preview

Stay ahead with the rest of our early NFL picks for Week 10.

🦅 Eagles +2.5 (-105) ⭐⭐⭐⭐

The Packers just lost at home to the Panthers, despite outgaining them 369-265. The Packers were just 1-of-5 in the red zone in that game, and they’ve now converted just 55.56% of their red-zone opportunities into touchdowns at home this season.

Things won’t get easier this week, as the Eagles rank third in the NFL in red-zone defense, allowing touchdowns on just 46.15% of opportunities. Meanwhile, defensively, the Packers are tied for 23rd, allowing opponents to score touchdowns on 63.64% of red-zone tries. With the Eagles scoring touchdowns on 85% of their red-zone tries (best in the league), what happens inside the 20-yard line will be the difference in this game.

The best price for Eagles +2.5 is -105 at bet365. That implies a 51.22% chance they cover. A $10 bet would profit $9.52.

📊 Live Eagles vs. Packers odds: Week 10

See the latest NFL odds for every game in Week 10.

🔢 Eagles vs. Packers opening odds

• Moneyline: Eagles +125 | Packers –150
• Spread: Eagles +2.5 (-110) | Packers -2.5 (-110)
• Over/Under: Over 45 (-110) | Under 45 (-110)

↔️ Eagles vs. Packers line movement

The Eagles opened as a 2.5-point underdog, but with the Packers losing to the Panthers, I expect this line to move in favor of the Eagles. While I could see this spread hitting 3 or 3.5, the Packers are ultimately home on Monday night, so at kickoff, the spread will probably be right where it is now.

I don’t expect much movement from the total. Both teams average over 25 points per game, but the Packers have the eighth-ranked scoring defense. Plus, the Packers only scored 13 against a Panthers team allowing 22.8 per game.

📈 Eagles vs. Packers trends & betting notes: MNF

• The Packers are 0-2 against the spread in their last two home games, losing once as a double-digit favorite
• Saquon Barkley has scored six touchdowns in his last four games against the Packers, and he’s topped 100 rushing yards in back-to-back games
• Josh Jacobs has rushed for at least 80 yards in both of his games against the Eagles while playing with the Packers
• Neither quarterback has a winning record on Monday night, as Jalen Hurts is 4-5 and Jordan Love is 2-2

📺 How to watch Eagles vs. Packers: Monday Night Football

• Date: Monday, Nov. 10
• Kickoff: 8:15 p.m. ET
• Location: Lambeau Field (Green Bay, Wis.)
• TV: ABC/ESPN