Eagles vs. Commanders Prediction & Opening Odds: NFL Week 16

My Eagles vs. Commanders prediction backs Philly to build on last week's momentum and cover on the road. 

The Eagles are the 5.5 or 6-point betting favorite for Saturday's game, which takes place at Northwestern Stadium in Landover, Md., and starts at 5 p.m. ET (FOX). I point to the Commanders' wild inconsistency as one of the reasons to back the defending champs as part of the NFL predictions for Week 16. 

🏈 Early Eagles vs. Commanders prediction & betting preview

Stay ahead with the rest of our early NFL picks for Week 16.

Eagles -5.5 (-115) ⭐⭐⭐

The Commanders are wildly inconsistent, even in defeat. Three of their four victories came against the two-win Las Vegas Raiders and New York Giants. 

In defeat, they're slightly more predictable, with five of the previous seven losses by at least 21 points. 

The Commanders had the seventh-worst defensive DVOA before their Week 15 victory over the Raiders, while Philly was ranked eighth overall before shutting out Las Vegas.

Despite the Las Vegas Raiders' ineptness, the 31-0 thrashing could represent a get-right game for the Eagles. Even if Jayden Daniels plays, I expect another 60-minute performance from the visitors as they look to enter the playoffs in peak form. 

Of the best sports betting apps offering -5.5, FanDuel provides the best price (-115). Those odds will profit $8.70 on a winning $10 bet. 

📊 Live Eagles vs. Commanders odds: Week 16

See the latest NFL odds for every game in Week 16. 

Eagles vs. Commanders opening odds

• Moneyline: Eagles -275 | Commanders +225
• Spread: Eagles -6 (-105) | Commanders +6 (-115)
• Over/Under: Over 45.5 (-105) | Under 45.5 (-115)

Eagles vs. Commanders line movement

bet365 and FanDuel are offering the Eagles at -5.5, with -116 and -115 odds, respectively. The other best sports betting sites have the Eagles at -6. The shorter odds at FanDuel and bet365 indicate the line will join the others at -6. If you're looking to back the Commanders, you'll want to wait. 

However, get in on the action now if you're backing the Eagles. 

📈 Eagles vs. Commanders trends & betting notes

• The Eagles are 9-6 ATS
• The Commanders are 6-9 ATS
• The Commanders' average margin of defeat is 14.1 points
• The Commanders lost two of their previous three home games by at least 22 points

📺 How to watch Eagles vs. Commanders

• Date: Saturday, Dec. 20
• Kickoff: 5 p.m. ET
• Location: Northwest Stadium (Landover, Md.)
• TV: FOX