Early Cowboys vs. Eagles Prediction, Odds & Picks: NFL Week 1, Sept. 4
It won't take long to find a great matchup for the 2025 NFL season, as the Super Bowl champion Philadelphia Eagles will host the NFC East-rival Dallas Cowboys, and my early Cowboys vs. Eagles predictions will go through how I think things will play out for the new-look Cowboys.
As we make our NFL predictions for Week 1, the Eagles are the betting favorite for Opening Night, giving up between 8 and 9.5 points. Kickoff from Lincoln Financial Field in Philadelphia is at 8:20 p.m. ET (NBC). My updated Cowboys vs. Eagles prediction can help you decide which team to back to start the season with an ATS win.
💰 Early Cowboys vs. Eagles prediction & best bet
Stay ahead with the rest of our early NFL predictions.
🦅 Eagles -7.5 (-115 via ESPNBet) ⭐⭐⭐⭐
While the Eagles struggled as the betting favorite in covering significant spreads last season (3-4 with spreads of 5.5 points or more), the headwind against the Cowboys resembles a hurricane.
The Parsons situation was the perfect embodiment of a train wreck. It's not just the fact that they lost their All-Pro edge rusher to the Green Bay Packers, which shook up NFL futures betting markets, but it was the way in which he departed the Lone Star State.
No matter how resilient and upbeat, team morale must be as low, if not lower, as it was when Dak Prescott injured his hamstring last season.
They now face the daunting prospect of facing one of the Super Bowl odds favorites on the road with first-time head coach Brian Schottenheimer at the helm.
Prescott will be under center for the first time in a competitive game since last year's Week 9 season-ending injury. It might take some time to readjust, which could present a nightmare situation against an Eagles team that had the best defensive DVOA last season.
And while nobody is quite sure how the new-look Eagles secondary will perform, Vic Fangio will take solace knowing his defense is facing a team that should be predictable to scheme against.
Dallas will be over-reliant on the passing game, as Javonte Williams, who had just 513 yards for Denver last season, spearheads what is expected to be a lackluster ground attack.
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📊 Cowboys vs. Eagles odds: Week 1
NFL odds update live in real time.
📈 Cowboys vs. Eagles opening odds
- Moneyline: Cowboys +260 | Eagles -325
- Spread: Cowboys +6.5 (-108) | Eagles -6.5 (-120)
- Over/Under: O46.5 (-110) | U46.5 (-110)
🔍 Cowboys vs. Eagles odds analysis
The Eagles were the 6.5-point betting favorite before Micah Parsons' abrupt exit. The Eagles' line increased to 7.5 points across our best sports betting apps. With Philly's odds ranging from -108 to -115, I don't see the spread increasing much, if at all, in the lead-up to kickoff. I wouldn't play the Eagles beyond -8.5.
🚑 Cowboys vs. Eagles injury report
📺 How to watch Cowboys vs. Eagles
- When: Thursday, Sept. 4
- Kickoff: 8:20 p.m. ET
- Where: Lincoln Financial Field (Philadelphia)
- How to watch: NBC
💡 NFL predictions for Week 1
- Early Cowboys vs. Eagles prediction
- Early Chiefs vs. Chargers prediction
- Early Ravens vs. Bills prediction
- Early Vikings vs. Bears prediction
❓ Cowboys vs. Eagles FAQs
Who is favored to win Cowboys vs. Eagles?
The Eagles are a -357 favorite to beat the Cowboys with those moneyline odds implying a 78.12% win probability with a $10 bet returning a $2.80 profit. The underdog Cowboys feature moneyline odds as high as +315, which imply a 24.1% probability of winning with a $31.50 profit on a $10 bet.
What are the opening odds for Cowboys vs. Eagles?
The Eagles were the 6.5-point betting favorite before the Cowboys traded away star defender Micah Parsons. Dallas is now a 7.5-point underdog. The total sits at 46.5 points.
How do NFL odds work?
When betting on NFL odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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