Cowboys vs. Eagles Early Predictions, Picks & Odds for Week 1

How will the Dallas Cowboys cope without Micah Parsons when they face the reigning Super Bowl champs on opening night? Gary Pearson offers his thoughts.

Gary Pearson

Last Updated: September 1, 2025 9:08 AM EDT • 4 minute read

Cowboys vs. Eagles Early Predictions, Picks & Odds for Week 1 — Pictured: Jalen Hurts looks on before the game against the New York Jets. Photo by Mark Smith via Imagn Images.

All eyes are on the new-look Dallas Cowboys when they face the reigning Super Bowl champs on opening night at Lincoln Financial Field, and my Cowboys vs. Eagles predictions detail what the visitors are up against.

The Eagles are the 7.5-point betting favorite for Thursday's game, which kicks off at 8:20 p.m. ET (NBC). The following NFL picks profile the opening betting lines while analyzing which team you should back.

📈Cowboys vs. Eagles early odds

See the NFL odds from our best NFL betting sites for every Week 1 game.

Cowboys vs. Eagles opening odds

Moneyline: Cowboys +260 | Eagles -325
Spread: Cowboys +6.5 (-108) | Eagles -6.5 (-120)
Over/Under: O46.5 (-110)/ U46.5 (-110)

Cowboys vs. Eagles odds analysis

The Eagles were the 6.5-point betting favorite before Micah Parsons' abrupt exit. The Eagles' line increased to 7.5 points across our best sports betting apps. With Philly's odds ranging from -108 to -115, I don't see the spread increasing much, if at all, in the lead-up to kickoff. I wouldn't play the Eagles beyond -8.5.

💰 Best Cowboys vs. Eagles early predictions: Week 1

🔎 NFL picks made Monday; odds subject to change. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

✅ Prediction: Eagles (-7.5) ⭐⭐⭐⭐

📊 Best odds: -105 via bet365 | Implied probability: 51.22%

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While the Eagles struggled as the betting favorite in covering significant spreads last season (3-4 with spreads of 5.5 points or more), the headwind against the Cowboys resembles a hurricane.

The Parsons situation was the perfect embodiment of a train wreck. It's not just the fact that they lost their All-Pro edge rusher to the Green Bay Packers, which shook up NFL futures betting markets, but it was the way in which he departed the Lone Star State.

No matter how resilient and upbeat, team morale must be as low, if not lower, as it was when Dak Prescott injured his hamstring last season.

They now face the daunting prospect of facing one of the Super Bowl odds favorites on the road with first-time head coach Brian Schottenheimer at the helm.

Prescott will be under center for the first time in a competitive game since last year's Week 9 season-ending injury. It might take some time to readjust, which could present a nightmare situation against an Eagles team that had the best defensive DVOA last season.

And while nobody is quite sure how the new-look Eagles secondary will perform, Vic Fangio will take solace knowing his defense is facing a team that should be predictable to scheme against.

Dallas will be over-reliant on the passing game, as Javonte Williams, who had just 513 yards for Denver last season, spearheads what is expected to be a lackluster ground attack.

Of our best sports betting sites, bet365 and Caesars offer the best value, where a winning $10 bet will yield a $9.52 profit.

🚑 Cowboys vs. Eagles injuries to watch

📺 How to watch Cowboys vs. Eagles

When: Thursday, Sept. 1
Kickoff: 8:20 p.m. ET
Where: Lincoln Financial Field (Philadelphia)
How to watch: NBC
Weather: 75 degrees, 30% chance of precipitation, wind 11 mph to 17 mph
Favorite: Eagles (-7.5 via bet365)

📃 NFL betting odds pages

Super Bowl Odds	NFL MVP Odds	NFL Offensive Player of the Year Odds
NFL Defensive Player of the Year Odds	NFL Offensive Rookie of the Year Odds	NFL Defensive Rookie of the Year Odds
NFL Coach of the Year Odds	NFL Comeback Player of the Year Odds	NFL Win Totals Odds
NFL Playoff Odds	NFL Draft Odds

❓ NFL betting FAQs

What does the spread mean in betting NFL?

In NFL betting, the spread is the number of points a team is favored to win or lose by. It levels the playing field for bettors by giving an advantage or disadvantage in points. Bettors win if their pick covers the spread.

Where can I find top NFL betting odds?

Make sure you look at our top NFL betting sites to find the best odds for NFL Sunday. These sportsbooks include Caesars, BetMGM, bet365, FanDuel, and DraftKings.

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Written by:
Gary Pearson

Gary Pearson has written professionally since 2010, focusing on sports betting since 2014. Before entering the sports betting space, he contributed to the Canadian Press, FanSided, the Hockey Writers, the Calgary Herald, and other publications. His work has also been featured in Sports Illustrated and Bleacher Report. Gary, who consumes sports like a blue whale devours plankton, has a penchant for writing predictions and analyses across several sports, including hockey, soccer, football, tennis, and more. He bets regularly, preferring single-game picks, props, and live betting. While there isn't a sport he has yet to dabble in, Gary prefers betting on soccer, hockey, and football. He studied at various post-secondary institutions, including the University of Calgary, SAIT Polytechnic, and Griffith University, located in Brisbane, Australia. Gary has a marketing degree and completed his bachelor's degree in journalism at Griffith University. He feels strongly that life experience is as essential as post-secondary education, helping formulate more accurate predictions and analyses. Gary believes that competing at a high level of amateur sports during his formative years helped him better understand an athlete's psyche and the nuances and complexities of a team's dynamic, both on and off the playing surface. He feels that knowledge is immeasurably important when offering his analytical expertise. He has lived on five continents and currently resides in Canada.