Best NFL Long Shot Parlay: Week 5 Moneyline Picks for Every Game

I'm featuring a 14-leg play in my best NFL long-shot parlay for Week 5, which predicts the outcome of each game on the weekend's docket. My moneyline NFL picks went 12-4 last week, so I'll need to sharpen up to cash an aspirational, yet conceivable 14-leg parlay. 

That monstrous parlay would yield a profit of $4,699 if all legs hit. My other two parlays, which are part of our NFL predictions for Week 5, feature five- and seven-leg plays. 

💰 My best NFL parlay picks for Week 5

Our NFL player prop odds tool shows the best NFL odds for every market across legal sportsbooks in your area.

I've loaded this five-leg parlay with three moneyline plays and two player props. The Seattle Seahawks are 3-1 and boast the league's best defensive DVOA, and the Tampa Bay Buccaneers will be without the injured Bucky Irving.

Terry McLaurin didn't win the race against time and will not face the Los Angeles Chargers, which should help facilitate a bounce-back game from the Chargers after their MetLife debacle.

I backed the Kansas City Chiefs to win and cover in my against-the-spread picks, so expecting them to win outright should be more straightforward.

Zay Flowers' total is set at 45.5 yards, way below the 73.5-yard total he eclipsed in three of four games this season. While I don't expect him to put together a spectacular outing, hitting the Over on 45.5 yards should be manageable with Cooper Rush under center, even though the wideout is going against an elite Houston Texans pass defense.

To culminate, I've picked Daniel Jones to tally at least 221 passing yards, which he's accomplished in all four games thus far. If all five legs hit, you'll earn $140.09 on a $10 bet. 

🎯 My best NFL long-shot parlay for Week 5

I added two legs to the previous 5-leg parlay, making this a 7-leg play that will yield a profit of $530.33 if everything hits.

The additions are Jared Goff to finish with at least 239 passing yards against the Cincinnati Bengals, and Ashton Jeanty getting into the end zone against the Indianapolis Colts. 

Jeanty broke out for three touchdowns last week against the Chicago Bears, while Goff hit the Over on his 238.5-yard total in the first two games. He's facing a team with the sixth-worst defensive pass DVOA that was carved to pieces in Denver against Bo Nix (326 yards).

Both additions are also featured in our NFL player props for Week 5. 

🚀 My best NFL moneyline parlay picks for every game

I've backed two underdogs in Week 5 while agreeing with one of the NFL upset picks from Mike Spector, which foresees the Denver Broncos finding a way to upset the defending Super Bowl champs at Lincoln Financial Field. 

I'm also predicting the Jaxson Dart-led New York Giants will upend the New Orleans Saints at Caesars Superdome. Despite boasting a better record, the G-Men are the slight betting underdog, presumably because it's Dart's first game on hostile terrain.

I'm concerned about Spencer Rattler's 0-10 record as an NFL starter. Records like that must fall at some stage, and he won't get many better opportunities. However, the Giants are the better team, albeit marginally. 

If all 14 moneyline picks hit, you'll earn $4,699 on a $10 bet. 

❓NFL parlay betting FAQs

What is a parlay bet in the NFL?

A parlay combines multiple bets (spreads, totals, props, or moneylines) into one wager, with all selections needing to win for the bet to cash. Parlays are popular in NFL betting because they offer bigger payouts.

How do NFL parlay odds work?

Parlay odds are calculated by multiplying the odds of each individual selection, which increases both the potential payout and the risk. The more legs you add, the higher the reward but the lower the probability of winning.

Are parlays a smart betting strategy for the NFL?

Parlays can be fun for chasing large payouts but are harder to win consistently. Many sharp bettors prefer single-game wagers, but NFL parlay bets can add excitement when used responsibly.

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