NFL AI Predictions Week 6: ATS Picks & Score Projections for Every Game

Last Updated: October 9, 2025 7:30 AM EDT • 7 minute read X Social Google News Link

After a tough week for our NFL AI predictions, we're looking to get back on track with our simulated NFL picks for Week 6.
We trained the latest ChatGPT model to make its weekly NFL predictions and projected scores for every game this week based on real-time search and advanced metrics, while offering a full box score and game preview for its five most confident picks.
If you can beat the bot in our free weekly NFL contest, you'll enter a draw to win SBR swag while competing for more than $5,000 in total prizes.
🤖 NFL AI predictions for Week 6
NFL AI predictions and score projections via ChatGPT simulation model with ATS pick confidence based on a 1-to-5-star scale and latest NFL odds.
Prediction | ATS pick | Confidence |
---|---|---|
Eagles 27, Giants 13 | Eagles -7.5 | ⭐⭐⭐⭐⭐ |
Broncos 23, Jets 16 | Jets +7.5 | ⭐⭐⭐ |
Chargers 26, Dolphins 19 | Chargers -4.5 | ⭐⭐⭐ |
Saints 19, Patriots 13 | Saints +3.5 | ⭐⭐⭐ |
Steelers 24, Browns 13 | Steelers -5.5 | ⭐⭐⭐⭐ |
Cowboys 30, Panthers 17 | Cowboys -3.5 | ⭐⭐⭐⭐⭐ |
Jaguars 24, Seahawks 17 | Jaguars -1.5 | ⭐⭐⭐ |
Colts 31, Cardinals 16 | Colts -6.5 | ⭐⭐⭐⭐⭐ |
Rams 27, Ravens 13 | Rams -7.5 | ⭐⭐⭐⭐⭐ |
Raiders 23, Titans 20 | Titans +4.5 | ⭐⭐ |
Buccaneers 20, 49ers 17 | Buccaneers -2.5 | ⭐⭐⭐ |
Packers 26, Bengals 13 | Bengals +14.5 | ⭐⭐⭐⭐⭐ |
Chiefs 31, Lions 27 | Chiefs -2.5 | ⭐⭐⭐ |
Bills 28, Falcons 20 | Bills -4.5 | ⭐⭐⭐⭐ |
Commanders 27, Bears 23 | Bears +4.5 | ⭐⭐⭐ |

🦅 Eagles (-7.5) at Giants

🚨 Eagles vs. Giants projected score
- Eagles 27, Giants 13
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Eagles | 7 | 10 | 3 | 7 | 27 |
Giants | 3 | 3 | 0 | 7 | 13 |
🔢 Eagles projected stats
- Passing leader: Jalen Hurts - 21/30, 238 yards, 2 TD, 1 INT; 6 rushes, 34 yards
- Rushing leader: Saquon Barkley - 17 rushes, 82 yards
- Receiving leader: A.J. Brown - 6 receptions, 94 yards, 1 TD
🔢 Giants projected stats
- Passing leader: Jaxson Dart - 19/33, 208 yards, 1 TD, 1 INT
- Rushing leader: Cam Skattebo - 13 rushes, 58 yards
- Receiving leader: Wan’Dale Robinson - 7 receptions, 71 yards, 1 TD
🔮 Eagles vs. Giants prediction
With Malik Nabers on IR and Darius Slayton sidelined, New York’s receiver room is thin for rookie starter Jaxson Dart. That lets Philly squeeze windows and sit on in-breakers while the front handles early-down runs. On offense, the Eagles can lean on Saquon Barkley and RPOs to keep Jalen Hurts in clean down-and-distance and pick spots for A.J. Brown over the middle. Our sim gives the Eagles three sustained scoring drives and a plus turnover margin that keeps the Giants chasing.
🤠 Cowboys (-3.5) at Panthers

🚨 Cowboys vs. Panthers projected score
- Cowboys 30, Panthers 17
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Cowboys | 10 | 7 | 7 | 6 | 30 |
Panthers | 3 | 7 | 0 | 7 | 17 |
🔢 Cowboys projected stats
- Passing leader: Dak Prescott - 22/32, 261 yards, 2 TD
- Rushing leader: Javonte Williams - 18 rushes, 86 yards, 1 TD
- Receiving leader: CeeDee Lamb - 7 receptions, 98 yards, 1 TD
🔢 Panthers projected stats
- Passing leader: Bryce Young - 22/36, 224 yards, 1 TD, 1 INT
- Rushing leader: Rico Dowdle - 12 rushes, 52 yards
- Receiving leader: Xavier Legette - 6 receptions, 73 yards
🔮 Cowboys vs. Panthers prediction
Carolina’s ground game perked up with Rico Dowdle last week, but the Panthers still ask Bryce Young to solve long-yardage too often. Dallas can win first down with simulated pressures and rally tackles, then let Dak Prescott work play-action and quick throws to CeeDee Lamb in his expected return. Expect the Cowboys to control possession and finish drives better in the red zone.
🐴 Colts (-6.5) vs. Cardinals

🚨 Cardinals vs. Colts projected score
- Colts 31, Cardinals 16
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Cardinals | 3 | 7 | 3 | 3 | 16 |
Colts | 7 | 10 | 7 | 7 | 31 |
🔢 Colts projected stats
- Passing leader: Daniel Jones - 21/29, 244 yards, 2 TD
- Rushing leader: Jonathan Taylor - 19 rushes, 104 yards, 1 TD
- Receiving leader: Michael Pittman Jr. - 6 receptions, 87 yards, 1 TD
🔢 Cardinals projected stats
- Passing leader: Jacoby Brissett - 20/32, 214 yards, 0 TD, 1 INT
- Rushing leader: Michael Carter - 12 rushes, 51 yards, 1 TD
- Receiving leader: Marvin Harrison Jr. - 5 receptions, 76 yards
🔮 Cardinals vs. Colts prediction
The Colts’ offense is humming with Daniel Jones operating cleanly on early downs and Jonathan Taylor finishing drives. Arizona lists Kyler Murray as day-to-day (foot) after missing practice; if he can’t go, it’ll be Jacoby Brissett under center. Either way, Indy’s front can compress the pocket and take away explosive shots, forcing a field-goal heavy script. Our sim has Indy winning the middle eight and pulling away late behind Taylor.
🐏 Rams (-7.5) at Ravens

🚨 Rams vs. Ravens projected score
- Rams 27, Ravens 13
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Rams | 7 | 10 | 7 | 3 | 27 |
Ravens | 3 | 3 | 0 | 7 | 13 |
🔢 Rams projected stats
- Passing leader: Matthew Stafford - 24/36, 289 yards, 2 TD, 1 INT
- Rushing leader: Kyren Williams - 17 rushes, 79 yards, 1 TD
- Receiving leader: Puka Nacua - 8 receptions, 102 yards, 1 TD
🔢 Ravens projected stats
- Passing leader: Cooper Rush - 18/31, 192 yards, 0 TD, 1 INT
- Rushing leader: Derrick Henry - 16 rushes, 68 yards, 1 TD
- Receiving leader: Zay Flowers - 6 receptions, 64 yards
🔮 Rams vs. Ravens prediction
With Lamar Jackson uncertain after a hamstring injury and Cooper Rush listed as QB2, Baltimore’s offense is pared back. The Rams’ front can play light and still muddy reads, while Matthew Stafford keeps the chains moving with middle-of-field throws to Puka Nacua and Davante Adams. Market movement toward LAR reflects that uncertainty; our sim shows Los Angeles stacking scoring drives and Baltimore settling too often.
🐯 Bengals (+14.5) at Packers

🚨 Bengals vs. Packers projected score
- Packers 26, Bengals 13
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Bengals | 3 | 3 | 0 | 7 | 13 |
Packers | 10 | 6 | 7 | 3 | 26 |
🔢 Packers projected stats
- Passing leader: Jordan Love - 20/31, 246 yards, 2 TD, 1 INT
- Rushing leader: Josh Jacobs - 22 rushes, 112 yards
- Receiving leader: Jayden Reed - 6 receptions, 83 yards, 1 TD
🔢 Bengals projected stats
- Passing leader: Joe Flacco - 21/35, 224 yards, 1 TD, 1 INT
- Rushing leader: Chase Brown - 11 rushes, 44 yards
- Receiving leader: Ja’Marr Chase - 7 receptions, 86 yards, 1 TD
🔮 Bengals vs. Packers prediction
Cincinnati turns to Joe Flacco on a short week after acquiring him midweek. That stabilizes the operation but caps the ceiling against a Packers defense that can play two-high, rally, and force long drives. With Josh Jacobs controlling tempo and Jordan Love getting defined reads off play-action, Green Bay wins the possession battle and keeps the Bengals in check. Still, this spread is too large after the Flacco move; our margin stays two scores.
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