NFL AI Predictions Week 16: ATS Picks & Score Projections for Every Game

With the playoffs in sight, our NFL AI predictions for Week 16 surge ahead with score predictions for every game this week and projected stat leaders for the five best bets by our AI model.

We trained the latest ChatGPT model to make its weekly NFL predictions and projected scores for every game this week based on real-time search and advanced metrics. If you can beat the bot in our free weekly NFL contest, you'll enter a draw to win SBR swag while competing for more than $5,000 in total prizes.

🤖 NFL AI predictions for Week 16

See all of our experts' NFL picks for Week 16 based on the latest NFL odds; pick confidence based on a 1-to-5-star scale.

🦬 Bills (-9.5) at Browns

Bills projected stats

• Passing leader: Josh Allen — 21/31, 248 yards, 2 TD, 0 INT
• Rushing leader: James Cook — 18 carries, 84 yards, 1 TD
• Receiving leader: Khalil Shakir — 6 receptions, 77 yards

Browns projected stats

• Passing leader: Shedeur Sanders — 18/34, 192 yards, 1 TD, 2 INT
• Rushing leader: Quinshon Judkins — 16 carries, 63 yards
• Receiving leader: Jerry Jeudy — 6 receptions, 71 yards

Bills vs. Browns prediction

Buffalo’s edge is that it can win this game without chasing volatility. The Bills are getting steady WR production from Khalil Shakir, and James Cook’s recent usage suggests Buffalo is comfortable playing through the run and letting Josh Allen pick spots rather than forcing hero ball. That’s a clean profile against a Browns offense that has shown it can unravel when pressure and long-yardage situations pile up.

Cleveland’s best path is a Quinshon Judkins-forward plan that keeps Shedeur Sanders out of obvious passing downs and turns this into a field-position game. But once Buffalo gets a lead, the Browns are forced to ask Sanders to push the ball more often — and his recent starts show that’s where mistakes can stack quickly. Buffalo’s consistency is why this projects as a controlled road win that covers.

Score prediction: Bills 24, Browns 10

⚜️ Saints (-4.5) vs. Jets

Saints projected stats

• Passing leader: Tyler Shough — 19/30, 214 yards, 1 TD, 1 INT
• Rushing leader: Devin Neal — 15 carries, 66 yards, 1 TD
• Receiving leader: Chris Olave — 6 receptions, 74 yards

Jets projected stats

• Passing leader: Brady Cook — 18/33, 196 yards, 1 TD, 2 INT
• Rushing leader: Breece Hall — 17 carries, 71 yards
• Receiving leader: Adonai Mitchell — 5 receptions, 58 yards, 1 TD

Jets vs. Saints prediction

This game projects as a grind because both offenses have had trouble finishing drives — and the Jets’ zero interceptions on the season and bottom-tier YAC profile speaks to how thin their margins are when they fall behind. With Brady Cook likely operating as the starter again after the injury chain forced him into the lineup, the Saints can keep the plan simple: protect Tyler Shough, take the easy completions, and let the run game carry red-zone possessions.

New York’s best path is Breece Hall-heavy volume to shorten the game, but once they’re chasing points, the profile gets shaky — and we just saw Cook throw three picks in a lopsided loss at Jacksonville. New Orleans isn’t explosive, but at home, in a low total environment, it’s enough to win and separate late.

Score prediction: Saints 20, Jets 13

🔴 Chiefs (-3.5) at Titans

Chiefs projected stats

• Passing leader: Gardner Minshew — 19/30, 214 yards, 1 TD, 1 INT
• Rushing leader: Kareem Hunt — 17 carries, 71 yards, 1 TD
• Receiving leader: Travis Kelce — 7 receptions, 81 yards

Titans projected stats

• Passing leader: Cam Ward — 20/33, 209 yards, 1 TD, 1 INT
• Rushing leader: Tony Pollard — 15 carries, 61 yards
• Receiving leader: Chigoziem Okonkwo — 5 receptions, 54 yards

Chiefs vs. Titans prediction

With Patrick Mahomes out and Gardner Minshew stepping in, the Chiefs’ cleanest path is a lower-risk, run-leaning plan featuring Kareem Hunt and quick-game throws to Travis Kelce — plus leaning on defensive field position rather than chasing explosives.

Tennessee can keep it scrappy with Tony Pollard and Cam Ward moving the ball in spurts, but their season profile shows a team that struggles to finish drives through the air, which caps their ceiling when playing from behind. Kansas City’s advantage is simply being more functional drive-to-drive, even with a backup quarterback.

Score prediction: Chiefs 27, Titans 16

🦁 Lions (-6.5) vs. Steelers

Lions projected stats

• Passing leader: Jared Goff — 23/34, 276 yards, 2 TD, 0 INT
• Rushing leader: Jahmyr Gibbs — 16 carries, 88 yards, 1 TD
• Receiving leader: Amon-Ra St. Brown — 8 receptions, 104 yards, 1 TD

Steelers projected stats

• Passing leader: Aaron Rodgers — 21/36, 238 yards, 2 TD, 1 INT
• Rushing leader: Jaylen Warren — 14 carries, 61 yards
• Receiving leader: DK Metcalf — 6 receptions, 82 yards, 1 TD

Steelers vs. Lions prediction

Detroit’s advantage comes from its ability to stress defenses horizontally and vertically without sacrificing efficiency. The Lions can stay balanced throughout the game, using Jahmyr Gibbs to punish light boxes and letting Jared Goff operate cleanly off play-action. Against a Steelers defense that has struggled to string together stops on long drives, Detroit’s red-zone execution becomes the separator rather than explosive plays alone.

Pittsburgh can trade scores early, especially if Aaron Rodgers gets time to work the intermediate areas and DK Metcalf wins on the outside. The issue is sustainability. Once Detroit establishes control of tempo, the Steelers are forced into longer possessions and higher-difficulty throws. Over four quarters, that pressure shows up in stalled drives and one or two key mistakes, allowing the Lions to pull away late and cover at home.

Score prediction: Lions 34, Steelers 24

🐦‍⬛ Ravens (-2.5) vs. Patriots

Ravens projected stats

• Passing leader: Lamar Jackson — 22/31, 241 yards, 2 TD, 0 INT
• Rushing leader: Keaton Mitchell — 14 carries, 76 yards, 1 TD
• Receiving leader: Zay Flowers — 7 receptions, 88 yards, 1 TD

Patriots projected stats

• Passing leader: Drake Maye — 20/35, 219 yards, 1 TD, 1 INT
• Rushing leader: TreVeyon Henderson — 16 carries, 64 yards
• Receiving leader: Kayshon Boutte — 6 receptions, 71 yards

Patriots vs. Ravens prediction

Baltimore’s edge is rooted in structure and efficiency rather than raw explosiveness. Lamar Jackson looks closer to full health after injuries derailed this offense, and the Ravens’ ability to stay ahead of the chains forces opponents to play perfect football to keep pace. Against a New England defense that has struggled to defend layered concepts and mobile quarterbacks, Baltimore can sustain drives without taking unnecessary risks.

The Patriots can compete early by leaning on TreVeyon Henderson, but that margin disappears as the game wears on. Once New England is forced to throw more consistently, Baltimore’s pass rush and coverage discipline can make life difficult for Drake Maye. The Ravens steadily build separation through the middle quarters and close this out without drama, making them one of the safest favorites on the slate.

Score prediction: Ravens 30, Patriots 17